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Biomedical subjects

K B Linton

Publications and source records attributed to K B Linton.

At least 19 recordsLinked to original sources
PubMed1989

Microbiology of the urethral (frequency and dysuria) syndrome. A controlled study with 5-year review.

In a clinical and microbiological study of women with urinary frequency and dysuria (excluding those with bacterial cystitis), 41 patients were compared with 42 control subjects. No difference was found between patients and controls in the incidence of infection by Chlamydia trachomatis or other sexually transmitted organisms. The numbers of lactobacilli and other fastidious organisms in the urine of patients with either mild or severe symptoms were similar and did not differ from the numbers in the urine of control subjects. The numbers of leucocytes in urine were also similar in both patients and controls. Our findings support the view that the urethral syndrome is not caused by bacterial or chlamydial infection.

Adult↗
PubMed1978

Effects of cephalexin, erythromycin and clindamycin on the aerobic Gram-negative faecal flora in man.

The effects of 5-day courses of orally administered cephalexin, clindamycin and erythromycin on the Gram-negative, aerobic faecal flora of healthy adults were examined. The concentration of cephalexin reached in the intestine was high enough to cause the emergence of resistant Gram-negative bacteria; organisms belonging to the genera Enterobacter, Citrobacter and Pseudomonas increased to easily detectable levels. The faecal concentration of erythromycin was high and caused a severe reduction of the coliform flora. Clindamycin administration resulted in a considerable increase in the coliform count; the increase in the proportion of klebsiellae was especially marked.

Administration, Oral↗
PubMed1975

Distribution of R plasmids among the O-antigen types of Escherichia coli isolated from human and animal sources.

The O-antigen types of 600 independently isolated Escherichia coli strains from human feces have been determined, and the types have been related to the antibiotic resistance patterns of the strains. The relative abundance of each O-antigen type differed in the susceptible and resistant series of strains. The majority (86%) of the resistant strains carried R plasmids. Resistant E. coli (20.3%) were found associated with O-antigen types 8, 9 and 101, whereas the susceptible strains covered a wide range of O-antigen types. Examination of 174 resistant strains isolated from calf feces also showed a prevalence of O-antigen types 8, 9, 101 (24.1%), and it seems probable that strains expressing these three O-antigen types commonly carry R plasmids in the alimentary tracts of man and calves. The number of strains not typeable with the O sera available were similar in the human (12.5%) and the calf (11.5%) series. There are no grounds for distinguishing "human" from "calf" E. coli on the basis of their O-antigen reactions.

Animals↗
PubMed1972

Antibiotic resistance and transmissible R-factors in the intestinal coliform flora of healthy adults and children in an urban and a rural community.

Faeces of healthy adults and of children under the age of 5, none of whom were attending hospital or receiving antibiotics, were examined for the presence of antibiotic resistant coliform bacilli.A higher proportion of children (67%) than of adults (46%) carried resistant strains and this difference was observed in both the rural and urban groups.Rural members of both age groups more often carried resistant organisms than urban members. Among rural adults, the incidence of drug-resistant strains was 63% in those whose occupation involved close contact with farm animals, compared with 29% in those with other occupations. The survey took place before the implementation of the Swann Report could have influenced the use of antibiotics in animal foodstuffs.Transmissible R-factors were demonstrated in 61% of the resistant strains. The incidence of transmissible resistance was similar among adults and children in town and country.

Adult↗