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K B Ocheltree

Publications and source records attributed to K B Ocheltree.

3 recordsLinked to original sources

A multi-element ultrasonic hyperthermia applicator with independent element control.

Acoustic field patterns from a planar multi-element ultrasonic applicator were determined experimentally and compared with theory. Measurements were obtained from square arrays of 4 and 16 elements. The acoustic fields produced by various configurations of individual square elements (3.6 cm X 3.6 cm) driven at 1 MHz were measured in water. Transverse and axial scans paths were used to characterize the acoustic beam for different aperture sizes and individual element excitations. Unequal power excitation of adjacent elements produced multiple peaked acoustic intensity patterns. While a simple theoretical model was not able to account for all the experimentally determined transverse and axial field patterns, a model including mechanical damping improved the agreement between theory and experiment. However, less ripple in the axial pattern was measured than predicted by either theoretical model. The ability of the applicator to generate acoustic field patterns suitable for local tissue heating was demonstrated by an experimental study in dog thigh muscle.

Animals↗

Determination of power deposition patterns for localized hyperthermia: a steady-state analysis.

Hyperthermia applicator design has concentrated on developing systems that allow control of power deposition patterns. In this paper, a method is detailed which uses the steady-state bioheat transfer equation and the target temperature distributions in normal and tumour tissue to calculate the desired steady-state power deposition patterns. This prospective thermal dosimetry approach is demonstrated analytically for three tumour models: an infinite half-space model; an infinite cylinder model; and a spherical model. A three-dimensional numerical method is demonstrated for two different tumour geometries and further applications of this method are discussed.

Body Temperature↗

Determination of power deposition patterns for localized hyperthermia: a transient analysis.

A technique for calculating the power deposition patterns required to maintain a uniform temperature throughout a tumour by application of the steady-state bioheat transfer equation was reported previously. In this paper the previous analysis is extended to define the power deposition patterns that are required to uniformly raise (and maintain) the temperature throughout the tumour to hyperthermic levels. The power deposition patterns are derived from the time-dependent bioheat transfer equation, and analytical results are developed for infinite half-space and spherical tumour models. A three-dimensional numerical method is presented which allows calculation of time-dependent power deposition patterns for arbitrarily shaped tumours. This method is applied to an example of a spherical tumour.

Hyperthermia, Induced↗