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Biomedical subjects

K Babich

Publications and source records attributed to K Babich.

7 recordsLinked to original sources
PubMed1994

Effect of hip position on gravity effect torque.

Hip position has been hypothesized to influence gravity effect torque (GET) at the knee during isokinetic testing; however, no data exist to support or refute this hypothesis. Therefore, the purposes of this study were 1) to determine if a significant difference exists between GET in seated and supine positions, 2) to determine the effect of the supine and seated GET on isokinetic peak torque values, and 3) to determine the relationship between hamstring flexibility and GET. Gravity effect torque was recorded in supine and seated positions. Peak torque values in flexion and extension were obtained on a isokinetic dynamometer at 1.047 and 5.235 rads.s-1 (60 and 300 degrees.s-1, respectively). Hamstring flexibility was assessed by the active knee extension test (AKET). The mean seated GET value was 5.64 Nm higher than the mean supine GET value (F(1,82) = 97.85, P = 0.0001). Significant correlations existed between hamstring flexibility and GET values measured in the seated and supine positions (r = 0.45, P = 0.0001, and r = 0.30, P = 0.0058, respectively). Significant differences in peak torque values occurred for three of the four isokinetic conditions when using different GET values (P-value 0.0002-0.0049). Although mean differences in peak torque values were only 2.43-4.23 Nm, these differences may translate to significant errors in the isokinetic measurement of the injured population undergoing rehabilitation. Furthermore, every attempt should be made to improve the validity of isokinetic testing. Therefore, we recommend the supine position for GET determination.

Adult↗
PubMed1992

Expression of the adenovirus E1B 175R protein and its association with membranes of Escherichia coli.

The E1B 175-amino-acid (175R) protein of adenovirus 2 is required for cellular transformation of primary cells and establishing cell morphology in lytically infected cells. To investigate the biochemical function of this protein, we constructed a bacterial expression vector (pKHB1-T) to produce the 175R protein in sufficient amounts for purification and biochemical analysis. On the basis of DNA sequencing, gel electrophoresis, and immunoblot analysis, the pKHB1-T-encoded 175R protein appears to be identical to that expressed transiently in mammalian or adenovirus-transformed cells. The bacterially produced viral protein was also found to be quite stable and without any modifications. Partial purification of the pKHB1-T-encoded protein revealed that the majority of its associates with the inner membrane of the bacterial cell. This, together with the possibility of the 175R protein containing an N-terminal amphipathic alpha-helix as a potential translocation signal, suggests that there may be a common mechanism of protein transport operating in both eucaryotic and procaryotic systems.

Adenoviridae↗
PubMed1991

Deletion mutant analysis of the Staphylococcus aureus plasmid pI258 mercury-resistance determinant.

Deletion mutant analysis of the mercury-resistant determinant (mer operon) from the Staphylococcus aureus plasmid pI258 was used to verify the location of the merA and merB genes and to show the existence of mercuric ion transport gene(s). ORF5 was confirmed to be a transport gene and has an amino acid product sequence homologous to the merT gene products from several gram-negative bacteria and a Bacillus species. Deletion analysis established that inactivation of merA on a broad-spectrum mer resistance determinant resulted in a mercury-hypersensitive phenotype. Gene dosage had no apparent effect on the level of resistance conferred by the intact mer operon or on the expression of an inducible phenotype, except that when the intact pI258 mer operon was on a high copy number plasmid, uninduced cells possessed a volatilization rate that was at most only 3.5-fold less than that observed for induced cells. There was no need for mercury ion transport proteins for full resistance when the mer operon was expressed in a high copy number plasmid.

Chromosome Deletion↗
PubMed1990

Dilemmas and directions for psychiatric nursing in the 1990s.

Problems with the recruitment of nurses to the specialty area of psychiatric nursing have stimulated much debate and discussion in the field. This article explores dimensions of psychiatric nursing education, science, and practice and their impact on the future of this specialty area of nursing. It proposes that the present task is to define more precisely the continuum of psychiatric mental health nursing both to differentiate between psychosocial (mental health) and psychiatric (mental illness) components of the role and balance the priority that psychiatric nurses give to each in educational curricula, research agendas, and practice settings.

Curriculum↗
PubMedDate not supplied

Blood pressure and mood responses in hypertensive patients on antihypertensive medications.

Nurse practitioners who are responsible for the clinical management of patients with hypertension must choose antihypertensive medications that minimize side effects. Nurse practitioners must be aware of the drugs' potential influences on physiologic and psychological variables and include adequate assessment of these responses in patients during treatment. Pindolol, propranolol, and hydrochlorothiazide were equally effective in reducing systolic and diastolic blood pressure in essential hypertensives, although pindolol and hydrochlorothiazide did not affect resting heart rate (an advantage in some patients). Hydrochlorothiazide was associated with a trend for several negative mood changes in black subjects; depression scores of black subjects were significantly increased with hydrochlorothiazide. The results of this study indicate the need to consider race and other factors in research about antihypertensive mood responses.

Adult↗