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Biomedical subjects

K Bayne

Publications and source records attributed to K Bayne.

7 recordsLinked to original sources
PubMed2000

Assessing animal care and use programs internationally.

As international collaborations become commonplace, new issues arise concerning the potentially variable quality of laboratory animals. The Associate Director and the Director of AAALAC International discuss efforts to harmonize facility procedures and practices of animal care and use globally.

Journal Article↗
PubMed1998

Developing guidelines on the care and use of animals.

Oversight of laboratory animal care and use in the research environment is multilayered. Federal and state regulations apply to many laboratory animal species; funding agencies frequently require adherence to additional guidelines; institutions may develop in-house policies; and an institution may choose to voluntarily participate in an accreditation program, indicating a commitment by the institution to apply the most rigorous standards to the animal care and use program. In general, regulations follow a prescriptive "engineering" approach, while guidelines applied to the care and use of research animals follow a "performance" approach, which defines the desired outcome in detail, but acknowledges that multiple methods may achieve that outcome. The performance approach relies on sound professional judgment, thereby allowing flexibility based on an institution's unique circumstances. Further, this approach should facilitate the international harmonization of animal care and use standards. The performance, or outcome, approach to developing guidelines is described, using the Guide for the Care and Use of Laboratory Animals (NRC, 1996) as the model.

Animal Experimentation↗
PubMed1991

Alternatives to continuous social housing.

Although social housing is desirable for social species of nonhuman primates, circumstances arise whereby social housing is precluded (for example, certain kinds of infectious disease or toxicologic research, when the health of the animal(s) would be compromised by social housing, and animals which respond behaviorally in an inappropriate manner to social housing). Nonsocial alternatives that provide increased environmental complexity to the home cage should then be considered. Nonsocial "environmental enrichment" schemes can be designed to enhance the expression of an individually housed nonhuman primate's locomotive/postural, manipulative, and foraging behaviors. In this way, nonsocial, but species-typical, behaviors can be promoted in the single cage housing condition.

Animals↗