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Biomedical subjects

K Ben Romdhane

Publications and source records attributed to K Ben Romdhane.

At least 19 recordsLinked to original sources
PubMed1996

[Primary leiomyosarcoma of the small intestine in a child].

BACKGROUND: Leiomyosarcomas of the digestive tract are very rare in children. They must be differentiated from benign tumors (leiomyoma, schwannoma...) and from other malignant tumors, sometimes with the aid of immuno-histochemical study. CASE REPORT: A five-year old girl suffered from an abdominal mass associated with fever and alteration of the general condition. An ileal tumor, 8 cm in diameter, was resected. Histological and immunohistochemical studies (anti-vimentin antibodies, anti-actin antibodies and PS100) confirmed the diagnosis of leiomyosarcoma. Uncomplete adjuvant chemotherapy failed to prevent relapse of the tumor. CONCLUSION: This case confirms the bad prognosis of such a tumor.

Child, Preschool↗
PubMed1996

[Invasive carcinoma of the cervix in young women in Tunisia].

A series of 133 patients, 35 years or less in age (mean: 31.8) presenting with a carcinoma of the cervix and treated at Salah Azaiz Institute from 1969 to 1989 was analysed and compared to a control group of patients older than 35 years (mean: 54). Neither clinical nor epidemiological particularities were found in the younger patients group, except an early sexual life and a high proportion of early stage tumours (33% versus 15.9% in the older women group). Overall survival of the younger women was dramatically worse than that of the older women: 40% and 50% at 5 years, 20% and 40% at 10 years, and 14% and 30% at 15 years, respectively. This difference is statistically significant in stage I-II patients. Young age, non-sterilization of the tumour after brachytherapy, and anemia, are associated with a poor prognosis.

Adult↗
PubMed1995

Melanin production in medullary thyroid carcinoma.

A case of melanin-producing medullary thyroid carcinoma is reported in a 51-year-old man. Histologically, the tumour had a typical pattern of medullary thyroid carcinoma with numerous scattered pigmented cells which contained large amounts of melanin pigment as confirmed by bleached Fontana-Masson stain. Immunohistochemical staining revealed positivity of almost all tumour cells for calcitonin and chromogranin, whereas S-100 protein and HMB-45 staining was positive only in the pigmented tumour cells. This finding confirms the ability of medullary thyroid carcinoma cells to have multidirectional differentiation, although melanocytic differentiation remains an exceptional phenomenon.

Amyloid↗
PubMed1995

[Microcystic adenoma of the pancreas].

Microcyst adenomas of the pancreas are rare tumours with characteristic cysts lining the cubic and cylindric epithelia with a clear cytoplasm rich in glycogen. Unlike, mucinous cyst adenomas, there is no tendency toward malignancy. We report a case in a 58-year-old woman and emphasize the importance of precise pre- or per-operative diagnosis in order to avoid excessive exeresis for benign tumour. Certain authors propose abstention and follow up.

Cystadenoma, Serous↗
PubMed1995

[Breast myoepithelioma. Report of a case].

Myoepithelial cell tumors of the breast are rare. They present diagnostic difficulties not only on frozen sections but also after fixation and paraffin embedding. These tumors can give rise to a wide range of clinical evolution... Treatment vary from simple excision for myoepitheliosis to mastectomy with axillary node dissection for malignant myoepitheliomas. Large excision is necessary for adenomyoepitheliomas because of the risk of recurrence and, more uncommonly, their proclivity to metastasis. We report the case of breast myoepithelioma in a 42 years old woman. The tumor was clinically, radiologically and macroscopically well demarcated. Histologically the tumor was composed of myoepithelial cells with few cellular atypias and a low mitotic activity. Tumor cells expressed vimentin, actin, S100 protein and cytokeratin. This particular immunohistochemical phenotype allows the differential diagnosis with other breast tumors.

Adult↗
PubMed1995

[Ovarian hydatic cyst. 7 cases].

Seven cases with echinococcal infection of the ovary, including 3 on both sides, were collected at the Salah Azaiz Institute of Tunis during a period of 23 years. This localisation is rare, even in an endemic country. The aetiology and pathogenesis of this affection may give rise to many different clinical signs, problems with pre-operative diagnosis. It is important to follow up these cases after operation in order to sport recurrences. The objective of surgical treatment is to achieve cure of both the hydatic cyst of the ovary and the primitive cyst simultaneously. Following this treatment, two difficulties may arise: the first one is preoperative rupture of the cyst; the second concerns fertility in these young women after two-sided salpingo-oophorectomy. Finally, when a pelvic cyst is observed systematic hydatic serology must be performed.

Adult↗
PubMed1995

[Breast angiosarcoma. Five case reports].

The authors report 5 cases of breast angiosarcoma collected in the Salah Azaiz Institute of Tunis, the only oncology center in this country, between 1969 and 1990. They enumerated 4,000 malignant breast tumors during this period; i.e. an incidence of 1.25%, higher than that in the world literature (0.4%). The mean age of patients was 44. Three were post-menopausal, and two were of childbearing age, one of whom was pregnant. This rare tumor is virtually limited to women. Affection is scarce, it affect's almost exclusively women. It generally present as a painless, ill-defined mass, without regional lymphadenopathy. The diagnosis of angiosarcoma is difficult since the histologic appearance is sometimes identical to that of a hemangioma. Hence the value of very thorough histologic examination of the entire operative specimen. Treatment is based upon mastectomy. The usefulness of adjuvant chemotherapy and/or radiotherapy is uncertain. The prognosis remains gloomy despite early diagnosis and treatment. The authors attempt in this study to identify the various features of this serious and uncommon condition, based upon the rare published cases in the world literature.

Adult↗
PubMed1995

[Struma ovarii. Three malignant cases and one benign case].

Four cases of struma ovarii were seen among 308 ovarian tumors removed surgically at the Salah Azaiz Institute, Tunis, Tunisia, between 1980 and 1989. This yields an occurrence rate of 1.3%, which is comparable to previously publishes rates (0.3% to 2%). One of the four tumors was malignant. Malignant transformation of struma ovarii is very rare (5% to 10%). The histologic diagnosis of malignancy is difficult, particularly in well-differentiated follicular forms. The prognosis is relatively favorable even in patients with metastases. Based on their personal experience and on a review of the literature, the authors discuss the diagnosis, management, and outcome of struma ovarii, in particular with malignant transformation.

Adult↗
PubMed1994

[Granular cell tumors of the breast. Apropos of two cases].

Granular cell tumors of the breast are rare. The clinical presentation, the poor macroscopical delimitation and the infiltrating appearance of the tumor cells between the mammary lobules and within the adipose tissue may lead to a diagnosis of carcinoma, especially on frozen section. The authors present two cases of granular cell tumor of the breast occurring in two women aged 19 and 59 respectively. Before surgery, the diagnosis was that of a malignant tumor. In both cases, frozen section suggested the diagnosis of a granular cell tumor, which was confirmed by immunohistochemical study in one patient.

Adult↗
PubMed1994

[Tumoral calcinosis: a clinical and pathological study of 8 cases reported in Tunisia].

Tumoral calcinosis is a distinct clinicopathological entity characterized by periarticular soft-tissue calcium deposits. It is a rare condition in Tunisia (8 cases during 23 years). Six patients were aged 14 years or younger. There was male predominance (SR: 7/1). Lesions were located about the hip in five patients and the elbow in three patients. Multiple localisations occurred in two patients. Histologically, all cases exhibited active phase of the disease. In our patients lesions were only surgically excised.

Calcinosis↗
PubMed1994

[Synovial sarcoma. Anatomoclinical aspects apropos of 8 cases].

Synovialosarcoma is a rare tumor, of difficult diagnosis. Authors report 8 cases diagnosed in the two pathology departments of Salah Azaïz Institute and the Universitary Hospital of Sfax, from 1985 to 1991. This tumor represents 2.96% of all soft tissues sarcomas treated in Salah Azaïz Institute. It occurs in young adults (the average age in our series: 28.8 years) with a male predominance (6 out of 8 cases), localized preferentially in the lower extremity. In the histological study, immunohistochemistry provides a great contribution in the diagnosis and classification of these tumors. The histoprognosis grading of Trojani applied to our cases shows the good correlation between the grade and the prognosis. Treatment is primarily surgical, consisting in wide excision to avoid recurrences that are unfortunately very frequent. Radiotherapy and chemotherapy give very inconstant results. Some authors recommend radiotherapy to sterilize the tumor field, and chemotherapy to prevent metastasis. The clinical course is characterized by a high frequency of local recurrences and pulmonary metastases.

Adolescent↗
PubMed1993

[Extensive malignant schwannoma of the sciatic nerve. Contribution of imaging techniques].

The authors reports a case of malignant schwannoma of sciatic nerve. Clinically, this tumor was manifested by a progressive tumefaction of the leg, and moderate pain, without functional signs. The origin of the sciatic nerve has been suspected by computed tomography, because its location, the vascular contacts, and the lesion's extension. Biopsy leads to confirm the nerve tumor, and precised the histologic type: malignant schwannoma. Local, regional and general extension did not premise treatment.

Female↗
PubMed1993

[Swallowing of an amniotic string by a fetus at term].

Amniotic band syndrome is a rare pathology which involves a group of fetal malformations due to the formation of bands between the fetus and the extraembryonic derivatives. These fetal malformations are extremely variable and their type depends upon the period of gestation during which the bands develop. In rare cases, these bands could strangulate the umbilical cord vessel and lead to fetal death. The authors report an exceptional case fo swallowing of the amniotic band by a fetus at term and fetal death due to strangulation of the umbilical cord vessels by amniotic band.

Adult↗
PubMed1990

[Tuberculosis of the cavum, report of two cases].

The authors report two cases of nasopharynx tuberculosis. This location is rare or misestimated. The sarcoidosis, the Wegener's granulomatis can be discussed. The diagnosis confirmation is based on the histologic features as a caseous necrosis in a langhans reaction cells or as the presence of mycobacterium tuberculosis at a Ziehl-Nielson coloration. The authors insist on the interest of a systematic biopsy of the nasopharynx at the presence of a nasopharynx lesion or a primitive cervical lymph-nodes. A bacteriologic investigation have to be done before the beginning of the specific treatment.

Adult↗