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Biomedical subjects

K Beswick

Publications and source records attributed to K Beswick.

8 recordsLinked to original sources

A blood spot assay for apo A1 and B lipoproteins and the apo B/A1 ratio.

A study of conditions for the elution of apo A1 and B lipoproteins from dried blood spots has led to the development of an apo B/A1 ratio assay with results for dried blood spots which are comparable with serum assays. This assay has been developed to be suitable for large scale population screening. The concept of measuring ratios for co-eluting blood constituents improves the accuracy and precision of blood spot assays and opens up the possibility that patients could take their own blood sample and send it to the laboratory by post.

Apolipoprotein A-I↗

Measurements and modelling of cloudwater deposition to moorland and forests.

The objective of the study was to measure the size dependence of cloudwater deposition and associated average ionic fluxes to vegetated surfaces. Measurements were made over a forest canopy at Dunslair heights in south Scotland and a moorland site, Great Dun Fell, in northern England. Measurements were made using the gradient and eddy correlation techniques. Eddy correlation measurements were made using an ultrasonic anemometer, a Knollenberg forward scattering spectrometer probe (to measure liquid water fluxes and fluxes of droplets in 1 microm size intervals) and a GSI particulate volume monitor (to measure liquid-water fluxes). Measurements were made at Great Dun Fell of the size dependence of droplet deposition velocity, using the gradient technique with two Knollenberg probes. Simultaneous gradient and eddy correlation measurements were also made at Great Dun Fell of average cloud-water fluxes, together with chemical analysis of cloud water composition, using a continuous analysis system. At Dunslair Heights, eddy correlation measurements were made using both the Knollenberg and Gerber Scientific Instruments (GSI) probes, while simultaneous gradient measurements using two GSI probes were also attempted. Samples of cloud water were collected at Dunslair Heights, using passive string collectors for chemical analysis by ion chromatography. The major findings of the study were: 1. The droplet deposition velocities measured by the two techniques were similar. 2. The deposition velocities were a strong function of droplet size. Considerable resistance to deposition was evident for droplets of less than 5 microm radius. Deposition velocities for particles from about 6 to 8 microm exceeded those for momentum. 3. Except when the droplets were very small or the winds very light, bulk cloud-water deposition velocities were about 80% or more of the momentum deposition velocities to forests.

Journal Article↗

General practice observed. Child abuse and general practice.

In a general practice of 9250 patients with 1841 children under 10 there were 12 cases of actual abuse during 1973-6. In March 1976 30 children were at risk. A preventive scheme was set up and the short-term outcome was good. There were no cases of serious abuse among the children at risk.

Child Abuse↗

A comparison of intravenous aminophylline and salbutamol in the treatment of severe bronchospasm.

Intravenous salbutamool or aminophylline was administered under double-blind conditions to 20 asthmatic patients presenting with severe dyspnoea and needing urgent treatment with bronchodilators. Ten patients received salbutamol and ten patients received aminophylline. Objective measurements showing improvement were recorded in nineteen patients. A greater response was produced by salbutamol although this failed to reach statistical significance. Neither drug affected pulse or blood pressure. It is suggested that intravenous salbutamol is an effective bronchodialtor in the treatment of acute exacerbation of asthma or bronchitis.

Acute Disease↗

Protocols used by UK general practitioners, what is expected of them and what solutions are provided.

A postal survey on attitudes to the use of clinical protocols by Family Health Service Authorities and general practitioners in the United Kingdom showed that some FHSAs had a relatively optimistic view of the implementation of protocols by GPs. Forty-two percent of the 61 FHSAs who responded stated that they had no policy for helping primary care introduce protocols in the key areas of the management or referral of asthma, diabetes, hypertension and ischaemic heart disease. The general practitioners identified these areas but there was a feeling of resentment by some of the respondents as they felt the electronic protocols were not in general user friendly. It was felt that the main General practitioner computer suppliers are capable of meeting the protocol needs of an increasingly computerised primary health care service for the future. The changes to the UK primary health scene are discussed in relation to protocol implementation by general practitioners.

Clinical Protocols↗