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Biomedical subjects

K Birch

Publications and source records attributed to K Birch.

40 records · Page 3Linked to original sources
PubMedDate not supplied

Evaluation of Hypo-test, a semiquantitative audio urine-glucose analyzer for blind diabetic individuals.

Hypo-test (Hypoguard Ltd., Suffolk, United Kingdom), a new semiquantitative audio urine-glucose analyzer for blind diabetic individuals, was tested for accuracy and reproducibility against a laboratory glucose method, and for ease of operation by two blind diabetic subjects. Hypo-test results were accurate for urine glucose in the range 0-0.75%, but there was a pronounced tendency for results to be too low at higher urine-glucose concentrations. The reproducibility at high urine-glucose concentrations was poor, and the meter was too sensitive to delays or decreases in the prescribed timing procedure. However, the two blind diabetic subjects found the instrument easy to operate.

Adult↗
PubMedDate not supplied

Absorption of subcutaneously infused insulin: influence of the basal rate pulse interval.

Eight insulin-dependent diabetic patients were given two constant infusions (each 1 IU/h) of 125I-labeled insulin into the abdominal subcutaneous tissue for about 12 h. Insulin was infused in pulses into one side of the abdomen in 6-min intervals (by means of an Auto-Syringe pump) and in the other side of the abdomen, insulin was infused in 1-h intervals (by means of a Medix pump). The size of the subcutaneous depots was continuously measured by counting the radioactivity at the infusion sites. After starting the infusions, the two depots were built up to steady-state levels at the same time and of the same size (approximately 3 IU) and with similar absorption rates. Thus, during basal rate insulin infusion, identical insulin absorption kinetics was achieved, irrespective of a 10-fold difference in the pulse rate.

Absorption↗
PubMedDate not supplied

Subcutaneous insulin infusion: change in basal infusion rate has no immediate effect on insulin absorption rate.

Eight insulin-dependent diabetic patients were simultaneously given subcutaneous infusions (1.12 IU/h each) of 125I-labeled Actrapid insulin in each side of the abdominal wall. After 24 h of infusion, the size of the infused insulin depots was measured by external counting for 5 h. The basal infusion rate was then doubled in one side and halved in the other for the next 4 h. Finally, 1.12 IU/h of insulin was given in both sides of the abdominal wall for an additional 3 h. The changes in the size of the depots were measured, and the absorption rates for each hour were calculated. During the first 5 h of infusion, the depot size was almost constant (approximately 5 IU) with an absorption rate that equaled the infusion rate. Doubling the infusion rate led to a significant increase in depot size, but the absorption rate remained unchanged for the first 3 h, and only thereafter was a significant increase seen. When the infusion rate was reduced to the initial 1.12 IU/h, the absorption rate remained elevated during the next 3 h. Correspondingly, when the infusion rate was decreased, the depot size also decreased, but the absorption rate remained unchanged for the first 3 h. The results show that a change in the basal insulin infusion rate does not lead to any immediate change in the insulin absorption rate. This should be considered when planning an insulin-infusion program that includes alteration(s) in the basal-rate setting.

Absorption↗