PubMed Health⌕ Search

Biomedical subjects

K Blum

Publications and source records attributed to K Blum.

131 records · Page 8Linked to original sources
PubMedDate not supplied

Neurodynamics of relapse prevention: a neuronutrient approach to outpatient DUI offenders.

The central nervous system rewarding properties of ethanol, cocaine, and heroin may activate a common catecholaminergic reward system in the mesolimbic circuitry of the brain. Driving-under-the-influence (DUI) offenders with either alcohol- or cocaine-related problems were studied. The neuronutrients SAAVE and Tropamine significantly reduced relapse rates and enhanced recovery in these DUI outpatient offenders over a 10-week period. Follow-up on both the SAAVE and Tropamine groups after 10 months revealed a 73% and a 53% overall recovery rate, respectively. These clinical results favor the use of these neuronutrients as adjuncts to psychological therapeutic modalities.

Adult↗
PubMedDate not supplied

Evidence for the importance of the "genotype" theory in alcohol seeking behavior: a commentary.

Consensus of the literature points towards a neuropsychogenetic model of alcoholism. Evidence in both animals and humans tends to support the proposed "genotype" theory of alcohol-seeking behavior, whereby a predisposition to alcohol preference may be mediated in part by either innate (genetic) or environmentally (stress and/or alcohol) induced brain opioid peptide dysfunction. Potential therapeutic rationale involving the utilization of novel inhibitors of carboxypeptidase A (enkephalinase) which raise endogenous enkephalin levels and possess anti-alcohol seeking effects is emphasized.

Alcohol Drinking↗
PubMedDate not supplied

Enkephalinase inhibition by thiorphan and subsequent response of ethanol, normorphine and enkephalins on mouse vas deferens.

In this study, a comparison was made between ethanol, normorphine methionine-enkephalin and [D-ala2] enkephalinamide and the ability of thiorphan, an enkephalinase inhibitor, to potentiate their in vitro activity to inhibit the electrically induced contractions of mouse vas deferens. Thiorphan did not significantly alter the response of either ethanol or normorphine on mouse vas deferens, whereas it significantly potentiated the response of methionine enkephalin.

Amino Acids, Sulfur↗
PubMedDate not supplied

The D2 dopamine receptor gene as a predictor of compulsive disease: Bayes' theorem.

The dopaminergic system, and in particular the dopamine D2 receptor, has been profoundly implicated in reward mechanisms in the meso-limbic circuitry of the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance (alcohol, drug, tobacco and food) seeking behavior. Decades of research indicate that genetics play an important role in vulnerability to severe substance seeking behavior. We propose that variants of the D2 dopamine receptor gene are important common genetic determinants in predicting compulsive disease.

Alleles↗