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Biomedical subjects

K Blumberg

Publications and source records attributed to K Blumberg.

10 recordsLinked to original sources

The toddler's cuboid fracture.

The authors describe two proved and two presumed cases of cuboid fractures in toddlers. These children were seen because of their inability to bear weight on the affected foot following a fall. Initial radiographs were normal; however, early scintigraphy revealed focal uptake in the cuboid. Follow-up radiographs demonstrated characteristic sclerosis of the base of the cuboid. Cuboid fractures are another example of a toddler's injury that may be difficult to diagnose at initial physical and radiographic examination.

Child, Preschool

Chemical specificity of pyruvate kinase from yeast.

Three analogs of phosphoenolpyruvic acid: (Z)-phosphoenol-3-fluoropyruvate, (Z)-phosphoenol-3-bromopyruvate and (Z)-phosphoenol-alpha-ketobutyrate were found to be substrates for yeast pyruvate kinase (ATP: pyruvate (Z)-O-phosphotransferase, EC 2.7.1.40)with maximal velocities much greater than those found for rabbit muscle pyruvate kinase. The analogs exhibited sigmoidal kinetics, which become hyperbolic upon addition of the allosteric effector, fructose 1,6-diphosphate. Moreover, the reaction of (Z)-phosphoenol-3-bromopyruvate with ADP to produce bromopyruvic acid and ATP irreversibly inhibited the enzyme with a half-life of 32 min.

Adenosine Triphosphate