Fractures of the cuboid bone in toddlers.
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Biomedical subjects
Publications and source records attributed to K Blumberg.
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The authors describe two proved and two presumed cases of cuboid fractures in toddlers. These children were seen because of their inability to bear weight on the affected foot following a fall. Initial radiographs were normal; however, early scintigraphy revealed focal uptake in the cuboid. Follow-up radiographs demonstrated characteristic sclerosis of the base of the cuboid. Cuboid fractures are another example of a toddler's injury that may be difficult to diagnose at initial physical and radiographic examination.
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Three analogs of phosphoenolpyruvic acid: (Z)-phosphoenol-3-fluoropyruvate, (Z)-phosphoenol-3-bromopyruvate and (Z)-phosphoenol-alpha-ketobutyrate were found to be substrates for yeast pyruvate kinase (ATP: pyruvate (Z)-O-phosphotransferase, EC 2.7.1.40)with maximal velocities much greater than those found for rabbit muscle pyruvate kinase. The analogs exhibited sigmoidal kinetics, which become hyperbolic upon addition of the allosteric effector, fructose 1,6-diphosphate. Moreover, the reaction of (Z)-phosphoenol-3-bromopyruvate with ADP to produce bromopyruvic acid and ATP irreversibly inhibited the enzyme with a half-life of 32 min.
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