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Biomedical subjects

K Bradshaw

Publications and source records attributed to K Bradshaw.

12 recordsLinked to original sources
PubMed1998

Ophthalmic manifestations of trisomy 8 mosaic syndrome.

Trisomy 8 mosaicism can present with a varied clinical picture. A significant number of cases have ocular manifestations. The most commonly reported in the literature have been corneal abnormalities and strabismus. We present a case of trisomy 8 mosaic syndrome with very different ophthalmic manifestations, some of which are previously unreported in the literature. The patient who was known to have trisomy 8 mosaic syndrome was referred with concerns about his visual abilities. He had a characteristic facial dysmorphism and other systemic features associated with this condition. Ophthalmic features included bilateral Duane's syndrome, bilateral myopic astigmatism, congenital pendular nystagmus, and macula hypoplasia. Electrodiagnostic tests confirmed extensive abnormality of cone function in both eyes. This case is discussed in relation to a review of the literature.

Astigmatism↗
PubMed1997

A Java-based multi-institutional medical information retrieval system.

JAMI (Java-based Agglutination of Medical Information) is designed as a framework for integrating heterogeneous information systems used in healthcare related institutions. It is one of the implementations under the W3-EMRS project 1 aimed at using the World Wide Web (Web) to unify different hospital information systems. JAMI inherited several design decisions from the first W3-EMRS implementation described in, including using the Web as the communication infrastructure and HL7 as the communication protocol between the heterogeneous systems and the W3-EMRS systems. In addition, JAMI incorporates the growing Java technologies and has a more flexible and efficient architecture. This paper describes JAMI's architecture and implementation. It also present two instances of JAMI, one for the integration of different hospital information systems and another for the integration of two heterogeneous systems within a single hospital. Some important issues for the further development of JAMI, including security and confidentiality, data input and decision support are discussed.

Computer Communication Networks↗
PubMed1995

Infantile presentation of X linked retinoschisis.

Five infants who presented with nystagmus and/or strabismus were found to have bilateral highly elevated bullous retinoschisis involving the macula. Haemorrhage was present within the schisis cavity or the vitreous in four patients. The bullous retinoschisis eventually reattached spontaneously leaving pigment demarcation lines. A family history of X linked retinoschisis (XLRS) was known in two of the patients but in the other three subsequent investigation showed other male family members to be affected. It is important to recognise this uncommon presentation of XLRS so that the correct diagnosis is made and appropriate genetic counselling is given. Surgical treatment is not usually indicated and the visual prognosis is better than the initial appearance may suggest.

Electroretinography↗
PubMed1994

Evaluation of clomiphene citrate and human chorionic gonadotropin treatment: a prospective, randomized, crossover study during intrauterine insemination cycles.

OBJECTIVE: To test the hypothesis that in couples undergoing IUI, actively managed cycles using clomiphene citrate (CC) stimulation, ultrasound monitoring, and hCG timing will result in increased pregnancy rate (PR) per cycle compared with unstimulated urinary LH-timed cycles. PATIENTS: Fifty-six couples with unexplained infertility (n = 26) or male factor infertility (n = 30) participated in the study. SETTING: Tertiary academic medical center. DESIGN: Prospective, randomized, crossover. Couples were randomized initially to one of the two study groups (treatment A: LH-timed IUI; treatment B: CC-stimulated, hCG-timed IUI). If no pregnancy occurred, each couple alternated between the two regimens during subsequent cycles, up to a total of four cycles. RESULTS: Twenty-nine couples completed the study and the analysis of 95 cycles revealed that among the male factor infertility group, one pregnancy occurred during the 26 cycles of each treatment group (PR per cycle of 3.9% for both treatment groups). In contrast, among the unexplained infertility group, there was a marked difference in the effect of treatments. During treatment A only one pregnancy occurred in 20 cycles (PR of 5% per cycle) whereas during treatment B, six pregnancies occurred in 23 cycles (PR of 26.1% per cycle). CONCLUSIONS: If IUI is chosen as the treatment modality in unexplained infertility, the addition of active ovulation management that includes CC stimulation, ultrasound monitoring of folliculogenesis, and hCG timing of ovulation increases the PR per cycle. In couples with male infertility, PR per cycle is low and is apparently not affected by the addition of active ovulation management.

Adult↗
PubMed1993

Patients' satisfaction survey: a review of in-patient attitudes towards care during a 12 month period.

In order to assess the value of medical and nurse team meetings in a programme designed to improve the quality of care given on a general medical ward, a 33% sample of recent in-patients was asked to complete a questionnaire about the quality of care that they received from doctors and nurses. Regular meetings were convened to respond to criticisms and improve overall care. During the year of the programme there was no significant change in the quality of care as perceived by patients and it is clear that this approach to improving care is ineffective.

Attitude to Health↗
PubMed1990

A prospective randomized study of pregnancy rates following intrauterine and intracervical insemination using frozen donor sperm.

Cryopreserved sperm have lowered fertility when compared with fresh sperm in artificial insemination by donor programs. The purpose of this study was to compare pregnancy rates following intrauterine insemination (IUI) and intracervical insemination (ICI) with cryopreserved sperm in a prospective trial using the patient as her own control. A total of 154 patients were randomized into alternating treatment cycles and underwent 238 cycles of IUI and 229 cycles of ICI. The pregnancy rate per treatment cycle was 9.7% following IUI and 3.9% following ICI. Treatment outcome was influenced by patient age, ovulatory status, and endometriosis. Pregnancy success correlated well with the post-thaw survival of sperm and the number of motile cells inseminated. In spite of having normal semen parameters, some donors were found to have markedly reduced sperm fecundity. We conclude that IUI with cryopreserved sperm can be an effective treatment for couples with infertility, genetic indications, or other reasons.

Adult↗
PubMed1989

Influence of induced hypotension and spinal distraction on feline spinal somatosensory evoked potentials.

Spinal cord injury may occur during surgical correction of spinal deformity, which is performed frequently under hypotensive anaesthesia. We have investigated the interaction between pharmacologically induced hypotension and distraction on feline spinal cord function. Twelve anaesthetized cats were subjected to hypotension (mean arterial pressure (MAP) 60 mm Hg) using a mixture of sodium nitroprusside and trimetaphan (1:5). No significant changes were observed in somatosensory evoked potentials recorded at T11. In six cats distraction was applied at L2-3 in 2.5-mm increments up to 1 cm, while MAP was maintained at 100 mm Hg (normotensive group). The remaining cats were subjected to the same distraction procedure at an MAP of 60 mm Hg (hypotensive group). In the hypotensive group, a reduction in amplitude of evoked response occurred at significantly less distraction than in the normotensive group. These data indicate that the feline spinal cord is more sensitive to spinal distraction under hypotensive conditions.

Animals↗
PubMed1984

Clinical evaluation of spinal cord monitoring in scoliosis surgery.

The somatosensory evoked potential (SEP) is a technique that can be used to monitor sensory conduction within the spinal cord throughout the course of spinal surgery. The authors describe the technique, stimulation, and recording parameters, which most critically affect the success and reliability of monitoring trials. In addition, we show that in all 40 patients tested fully, the SEP results were in complete agreement with the clinical findings at the time of the wake-up test. In this series, there was no instance of a "false-positive" SEP result, or of the SEP failing to detect neural damage. Temporary, neurologic deficit occurred on two occasions, which are described in detail. These show that the SEP is rapid, enables neurologic complications to be detected at an early stage of surgery, and can identify lateralized problems. It is concluded that the technique may provide a clinically valuable method for continuous and prolonged monitoring of spinal cord function.

Adolescent↗