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Biomedical subjects

K Bremer

Publications and source records attributed to K Bremer.

At least 55 records · Page 3Linked to original sources
PubMed1977

[Retrospective analysis of the clinical relevance of the Kiel classification of malignant non-Hodgkin's lymphomas (author's transl)].

405 cases with non-Hodgkin's lymphomas have been diagnosed according to the Kiel classification and analysed retrospectively. 314 patients with non-Hodgkin's lymphomas of low-grade-malignancy (chronic lymphocytic leukemia, lymphoplasmacytoid, centrocytic, centrocytic, centroblastic-centrocytic lymphoma) manifested significantly higher median survival times than the 91 patients with non-Hodgkin's lymphomas of high-grade malignancy (lymphoblastic and immunoblastic lymphoma). Within the group of patients with low-grade malignant lymphomas distinct prognostic differences were found whereas survival times in patients with lymphoblastic or immunoblastic lymphomas were rather similar. The lymphoblastic lymphoma showed a bimodal curve of age distribution whilst all other lymphomas had a maximum of incidence in the seventh decade of life. Increased frequency of B-symptoms did not necessarily represent an unfavorable prognostic factor for the lymphoma entity concerned. Except for chronic lymphocytic leukemia the highest incidence of initial bone marrow involvement was seen in lymphoplasmacytoid, centrocytic and lymphoblastic lymphomas. Centrocytes have been observed in peripheral blood of patients with centrocytic and centroblastic-centrocytic lymphomas, even though lymphocytosis did not exist. Monoclonal hypergammaglobulinemia was found in only 43% of the sera from patients with lymphoplasmocytoid lymphoma. In this disease, it was possible to differentiate between a lymphonodal, a splenomegalic and an extranodal manifestation.

Age Factors↗
PubMed1975

Extramedullary manifestation of the blastic phase of chronic myelocytic leukemia: A chromosome study.

Two patients with extramedullary manifestation of the blastic phase of chronic myelocytic leukemia (CML) are reported. 100% of the metaphases derived from extranedullary sites were aneuploid. Despite the absence of blastic changes in the bone marrow and the peripheral blood, a significant proportion of the metaphases derived from these tissues also showed aneuploidy. It is suggested that maturation and differentiation of aneuploid myeloblasts are influenced by their environment.

Adult↗
PubMed1975

[Lymphocyte in chronic lymphatic leukemia].

In patients with chronic lymphatic leukemia (CLL) the majority of peripheral blood lymphocytes was characterized as B cells by surface membrane markers. Ultrastructural studies revealed a reduction of the cytoplasmic area. Furthermore, the number of lysosomes was diminished corresponding to a decreased activity of lysosomal hydrolases. Increasing blood lymphocytosis was paralleled by an increase of the percentage of lysosome-poor lymphocytes. Response of CLL lymphocytes to in vitro stimulation with PHA and PWM was either lacking or diminished and/or delayed, and the number of transformed cells was reduced. Thus, the majority of CLL lymphocytes appears to represent both morphologically and functionally abnormal neoplastic b cells. During the early and later phase of stimulation the mitogen-reactive CLL lymphocytes exhibited alterations of the lysosomal apparatus similar to those observed in normal cells. The reactive lymphocytes may be derived from residual populations of normally functioning T and/or B cells. However, the neoplastic cells may also be able to respond to the mitogens. In vivo studies showed impaired kinetics of circulation and recirculation of CLL B lymphocytes, whereas the T cells were normal in this respect.

B-Lymphocytes↗
PubMed1975

Impaired exchange of autotranfused blood lymphocytes between intra- and extravascular pools in patients with untreated chronic lymphocytic leukemia.

Autotransfusion of 3H-cytidine labeled blood lymphocytes was performed in 4 normal subjects, 3 patients with non-leukemic malignant lymphoma (1 reticulum cell sarcoma, 2 lymphosarcoma), 2 treated, non-leukemic patients with chronic lymphocytic leukemia (CLL) and 11 untreated CLL patients. Immediately after autotransfusion on the average only 41.3% and 47.5% of the infused labeled lymphocytes were recovered in the blood of the normal subjects and of the untreated CLL patients, respectively. During the first hour, in the normal subjects a higher proportion of labeled cells disappeared from the blood that in untreated CLL patients. Thereafter, this initial rapid decrease ceased and levelled off into a plateau with rather constant recovery values. At this time (1-4 hours after autotransfusion), on the average only 6.7% of the normal lymphocytes, but 27.8% of the untreated CLL lymphocytes were recovered in the blood. In the non-leukemic lymphoma of the untreated CLL lymphocytes were recovered in the blood. In the non-leukemic lymphoma patients and treated CLL patients the autotransfused lymphocytes exhibited circulation kinetics similar to those of the normal lymphocytes. The majority of blood lymphocytes from untreated patients with CLL seem to be characterized by a poor exchange rate between intra- and extravascular lymphocyte pools and a prolonged intra-vascular life span. These findings agree with the impaired recirculation kinetics of CLL lymphocytes and their abnormal 0ehaviour in several "in vitro" tests dealing with other lymphocyte functions.

Blood Transfusion, Autologous↗