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Biomedical subjects

K Breur

Publications and source records attributed to K Breur.

17 recordsLinked to original sources
PubMed1978

Dose-modifying effect of misonidazole on the radiation response of growing cartilage in mice.

Misonidazole administered before a single dose of 15 Gy X-rays enhances the radiation response of growing bone in mice by a factor 1.3. In combination with split-dose irradiation of twice 7.5 Gy the drug did not cause significant enhancement. These results are most likely due to the existence of hypoxic cells in growing cartilage as has been demonstrated already by other authors.

Animals↗
PubMed1975

Non-Hodgkin's lymphomata: clinical features in relation to histology.

An analysis is given of the clinico-pathological correlations of non-Hodgkin's lymphomata in 332 patients referred to the Netherlands Cancer Institute in Amsterdam and the Rotterdam Radiotherapy Institute. Clinical staging proved to be an important prognostic index. In Stage I the 5 year survival was 55%, in Stage II 25% and in Stages III and IV less than 10%. The presence of follicular structures in non-Hodgkin's lymphomata has similarly an important prognostic significance especially in Stage I and II. In lymphocytic lymphomata a larger cell size is correlated with less favourable prognosis. The presence of macrophages in non-Hodgkin's lymphomata is found in patients with short survival. The histiocytic lymphomata have a different survival pattern from the lymphocytic lymphomata in Stages I and II.

Follow-Up Studies↗
PubMed1975

Spread according to histology in non-Hodgkin's lymphomata.

The spread of non-Hodgkin's lymphomata was investigated in a group of 323 cases. Differences were sought between 4 histological groups: lymphocytic vs histiocytic lymphomata and diffuse vs follicular types. Histiocytic and follicular types were rare in childhood. Histiocytic lymphomata, compared with lymphocytic ones, were more often confined to sites above the diaphragm. They exhibited a higher rate of loco-regional recurrences within the first 3 months and also of late recurrence after 4 years. Lymphocytic lymphomata of the follicular type more commonly presented with nodal involvement below the diaphragm as primary or secondary site than the diffuse form. Follicular types of lymphoma compared with diffuse types, occurred more frequently in women. They were more seldom seen as primary or secondary sites in extranodal localizations. They had a smaller chance of late disease recurrence and were associated with a longer survival time after first recurrence. The mediastinum often remained clinically uninvolved. With regard to this mediastinal "skip" no differences were found between the histological groups.

Female↗