Biomedical subjects

K Burry

Publications and source records attributed to K Burry.

7 recordsLinked to original sources

PubMed1998

Treatment-seeking women at menopause: a comparison between two university menopause clinics.

OBJECTIVE: We wished to determine the expectations of women about the benefits of hormone replacement therapy (HRT) and how these expectations may be influenced by cultural factors and previous experience of disease by the patient or in their families. DESIGN: The attitudes of patients seeking HRT in Belfast, United Kingdom (n = 218) and Portland, USA (n = 100) were compared at their first clinic attendance using a questionnaire. Physical and mental health issues, previous use of HRT and continuance on treatment were compared. RESULTS: Belfast women were less healthy than their Portland counterparts, with a higher prevalence of cardiovascular disease and psychiatric disorders (p < 0.05). Belfast patients showed a significantly lower continuance with treatment (p < 0.01). Collectively, the patients ranked relief of menopausal symptoms as their main expectation from HRT followed by osteoporosis protection, psychiatric relief and cardioprotection. The Belfast group had higher expectations for the relief of psychological/psychiatric problems (p < 0.01). All women with a family history of cardiac disease or fractures were more concerned for the protective effects of HRT than those women with no relevant family history (p < 0.05). There were cultural difference in expectations from HRT with Belfast women expecting more psychological/psychiatric relief and therefore trying a greater number of preparations. CONCLUSIONS: These findings suggest that menopausal women in both countries are well informed about the potential protective benefits of HRT, and now expect an improvement in the quality of their lives well beyond the relief of menopausal symptoms.

Attitude↗

PubMed1997

Retreatment with nafarelin for recurrent endometriosis symptoms: efficacy, safety, and bone mineral density.

OBJECTIVE: To assess the efficacy, safety, and effect on bone mineral density of a 3-month course of retreatment with intranasal nafarelin acetate for recurrent symptoms of endometriosis. DESIGN: Multicenter, open-label, nonrandomized clinical trial. SETTING: Eleven hospital-based and private practices. PATIENT(S): Thirty-six women with endometriosis symptoms recurring after 3 or 6 months of treatment with nafarelin. INTERVENTION(S): Nasal nafarelin 200 micrograms twice daily for 3 months. MAIN OUTCOME MEASURE(S): Assessments for dysmenorrhea, dyspareunia, pelvic pain, tenderness, and induration. Measurement of bone mineral density of the lumbar spine. RESULT(S): Improvements from admission to the end of retreatment were significant for dysmenorrhea, pelvic pain, tenderness, induration, and dyspareunia. Three months after retreatment ended, mean symptom scores for dysmenorrhea and pelvic tenderness, although worse than at the end of retreatment, were still significantly better than scores at admission. Mean bone mineral density 3 months after retreatment was 0.56% lower than before retreatment and 1.94% lower than before initial treatment. CONCLUSION(S): Three-month nafarelin retreatment for recurrent endometriosis symptoms was effective and safe.

Administration, Intranasal↗

PubMed1986

Fetoplacental steroid metabolism in prolonged pregnancies.

The response to an intravenous load of 50 mg of dehydroepiandrosterone sulfate given to women with a pregnancy prolonged to more than 42 weeks was compared to the response in control pregnant women at 40 weeks. The half-life of dehydroepiandrosterone sulfate was longer in the prolonged pregnancy group than in the control group (mean +/- SEM, 3.64 +/- 0.24 hour versus 2.78 +/- 1.08 hour, p less than 0.05), and the rises of serum free estrone and free estradiol 4 hours after infusion were less in the prolonged pregnancy group than in the control group. Maternal venous and umbilical venous estrone, estradiol, free estriol, and dehydroepiandrosterone sulfate levels were compared in samples from control, postmature, and postterm groups. Umbilical estriol concentrations were significantly less in the postmature group (67.8 +/- 9.5 ng/ml, mean +/- SEM) than in the control group (136 +/- 22.8 ng/ml, mean +/- SEM, p less than 0.01), but there were no significant differences between dehydroepiandrosterone sulfate, estrone, and estradiol levels. Maternal venous estriol levels were lower in the postmature group (13.3 +/- 2.1, p less than 0.05) than in the control group (25.0 +/- 4.9). A reduction in overall placental estrogen production was indicated by the results of the dehydroepiandrosterone sulfate loads in the patients with prolonged pregnancy, yet the normal umbilical venous estrone and estradiol levels do not fit this conclusion. There is no explanation for the discrepancy at this time.

Dehydroepiandrosterone↗

PubMed1986

Estradiol and hemodynamics during ovulation induction.

Left ventricular size and stroke volume increase in human pregnancy and during estrogen administration in laboratory animals. In order to determine if elevated levels of endogenous estrogens in humans produce hemodynamic changes similar to those that occur during pregnancy, 14 patients were studied during ovulation induction at day 8 +/- 2 (SD) (proliferative phase) and at day 14 +/- 4 (midcycle) of their cycles. M-mode echocardiography was carried out with the patient in the left lateral decubitus, head down and head up positions. The mean serum estradiol level was 294 +/- 234 (SD) pg ml-1 at day 8 +/- 2 (treatment day) and it increased to 1503 +/- 531 pg ml-1 at day 14 +/- 4 (cycle day) of the same cycle. This change in serum estradiol was significant (P less than 0.001), associated with an increase in left ventricle diastolic dimension of 2.3 +/- 1.1 mm (P less than 0.001). During the same time period stroke volume and cardiac index correspondingly increased. Heart rate, fractional shortening, and blood pressure did not change and systemic vascular resistance decreased. Many of the cardiovascular adaptations of pregnancy are duplicated by high levels of endogenous estrogens and these changes are evident in as few as 6 days. Thus, we conclude that changes in endogenous estrogen correlate with certain cardiovascular parameters, the most striking of which is the left ventricular size. This may be one of the adaptive mechanisms by which the maternal circulation adapts to pregnancy.

Adult↗

PubMed1985

The effect of exercise on uterine activity in the last eight weeks of pregnancy.

In order to determine if moderate maternal exercise increased uterine activity, a prospective study was done during the last 8 weeks of pregnancy in 17 women. Two forms of exercise were chosen, weight-bearing (running) and non-weight-bearing (stationary bicycle), to study this hypothesis. The results show that with these types of exercise no increase in uterine activity was noted. This is useful information to convey to pregnant patients ready to engage in a physical fitness program.

Adult↗

PubMed1984

Plasma ascorbate concentrations and blood cell dehydroascorbate transport in patients with diabetes mellitus.

Rates of dehydroascorbate uptake by blood granulocytes and mononuclear cells are slower, and plasma ascorbate concentrations are lower, among persons with diabetes mellitus than in nondiabetic subjects. These measurements do not correlate with one another or with simultaneously measured plasma glucose or glycosylated hemoglobin; they do not differ with type of diabetes or mode of treatment. In those diabetic granulocytes that exhibit slow dehydroascorbate uptake, maximal velocity (Vmax) transport rates for dehydroascorbate, 2-deoxyglucose, and 3-O-methylglucose are decreased, each to the same degree, while Km values for transport of these ligands are not different from those observed in nondiabetic cells. Since diffusion of these ligands is facilitated by a common transporter, these observations may reflect decreased numbers of glucose transporters in the plasma membranes of some diabetic leukocytes.

3-O-Methylglucose↗

PubMed1979

Differentiation and regulation of peripheral androgen metabolism in rats and rhesus monkeys.

The sex-unique metabolic network for steroids is induced neonatally in male rats. The metabolic clearance rates (MCR) of dehydroepiandrosterone and testosterone are similar for both sexes of rats despite quantitatively significant sex differences in individual enzyme activities of adults; neonatally androgenized females had a 2-to 3-fold increase in MCR but cyproterone had no effect. The MCRT and MCRDHA of castrated adult male rhesus monkeys are the same as those of normal males; the MCRDHA is 4-fold greater. Testosterone treatment suppressed the MCRDHA of the castrated groups but estradiol treatment did not. The sex-steroid binding protein (SBP) levels were lower in males than females, and these values were reduced by testosterone. Estrogen suppressed the higher SBP values of females. The sex-steroid milieu of adult rhesus monkeys regulates SBP binding capacity and the enzyme activities of skin measured in vitro. Prenatal testosterone does not exert a crucial role in presetting the peripheral metabolic network in rhesus monkeys.

Age Factors↗