Biomedical subjects
Publications and source records attributed to K C Joshi.
A series of fluorinated arylsulfonylthiosemicarbazides and arylsulfonylhydrazones has been synthesized. A representative number of the synthesized compounds have been screened for their antibacterial activity but none of the compounds showed significant activity.
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The synthesis of 2-allylthio-3-(4'-fluorophenyl)-5,6,7,8-tetrafluoro-4-quinazolone, 2-n-propylthio-3-(4'-fluorophenyl)-5,6,7,8-tetrafluoro-4-quinazolone, 3-(4'-bromophenyl)-5,6,7,8-tetrafluoro-2,4-quinazolinedithione, and seven fluorinated 2-alkyl/phenyl-3-aryl-4(3H)-quinazolones is described. The synthesized compounds were screened for CNS depressant activity using pentobarbital sleeping time, pentylenetetrazol convulsions, and condition avoidance test as the parameters. Most of the screened compounds exhibited significant depressant activity.
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