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Biomedical subjects

K C King

Publications and source records attributed to K C King.

33 records · Page 2Linked to original sources
PubMed1977

Lack of gastrointestinal enhancement of the insulin response to glucose in newborn infants.

Forty-five normal newborn infants were infused with glucose at constant rates by intravenous or nasogastric routes. Blood glucose rose to higher levels during IV than during NG infusions at identical rates; however, the glycemic responses were similar when NG glucose infusions at 12 mg/minute/kg were compared with IV infusions at 6 mg/minute/kg. The plasma insulin responses to glucose were not enhanced by NG administration. Thus, enterohormonal responses to glucose may not affect pancreatic beta cell regulation of glucose assimilation in the newborn period.

Administration, Oral↗
PubMed1976

Effects of pregnancy on hemoglobin AIc in normal, gestational diabetic, and diabetic women.

Hemoglobin AIc, a normal minor hemoglobin, has glucose linked by a Schiff base to the N-terminal end of the beta chain. The glucose interferes with the binding of 2,3 diphosphoglycerate, probably resulting in an increased affinity of that hemoglobin for oxygen. Hb AIc is increased to twice normal levels in juvenile-onset (insulin-dependent) diabetes. In the present studies, the Hb AIc, when expressed as per cent of total hemoglobin, was found to be elevated slightly in pregnany normal (m = 6.97 per cent), pregnant nondiabetic obese (m = 6.89 per cent), and gestationally diabetic subjects (m = 8.77 per cent) above that of normal females (m = 5.68 per cent). A remarkable difference was observed between the nonpregnant diabetics (m = 12.77 per cent) and the pregnant diabetics (m = 8.46 per cent). This decrease in the level of Hb AIc in diabetics who are pregnant more than 30 weeks may reflect either a better state of diabetic control and/or a compensatory mechanism to protect the fetus by facilitating oxygen exchange from mother to fetus.

Adult↗
PubMedDate not supplied

Using therapeutic silence in home healthcare nursing.

This article examines the role of silence in the practice of home healthcare nursing. The literature is limited regarding the use of silence in therapeutic relationships in home healthcare nursing. Silence is often uncomfortable for the home healthcare nurse and the client, but when silence is used purposefully by the nurse, effective communication can be a successful intervention.

Communication↗
PubMedDate not supplied

Gastrointestinal enhanced insulin release in response to glucose in newborn infants.

The purpose of this investigation was to determine whether or not gastrointestinal (GI) enhanced insulin response occurs in newborn infants soon after birth. Glucose infusion by intravenous or orogastric routes was given to infants during the first 4 days of life, aiming at achieving similar plasma glucose concentrations. Their plasma insulin responses were then compared. Thirty term, newborn infants (10 appropriate for gestational age, 8 small for gestational age, 6 large for gestational age, and 6 infants of diabetic mothers) were studied. With intravenous glucose infusions of 8 mg/kg/min or orogastric infusion of 16 mg/kg/min, the plasma glucose concentrations achieved were similar and approximated 110 mg/dl. Plasma insulin responses were greater in infants receiving glucose via the GI route. The finding was in contrast to our previous data, in which no GI enhancement of insulin response was demonstrated. The present data suggest that in the term newborn infant, GI enhanced insulin release occurs only when a threshold of plasma glucose concentration has been exceeded. It appears that the enteroinsular axis is functional in newborns soon after birth.

Administration, Oral↗