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Biomedical subjects

K C Lyle

Publications and source records attributed to K C Lyle.

10 recordsLinked to original sources
PubMed1987

Experiences with gossypol as a male pill.

In 1981 to 1983 we performed a clinical study with gossypol involving 152 participants, and in 1983 to 1985 we conducted another study of 120 participants. The first study was aimed at confirming gossypol's antifertility efficacy and determining the existence of side effects. The objective of the latter study was to find out whether the addition of a potassium salt supplement or a potassium-sparing agent could alleviate the side effect of hypokalemia. In both studies, the participants took a gossypol pill, 20 mg/day for 60 to 75 days for loading, and 50 mg/wk for maintenance. All participants were followed up for a year. The antifertility efficacy was found to be more than 90%, and the chief side effect was lowered serum potassium. In our 1983 to 1985 study, we concluded that since neither potassium supplementation nor triamterene solved the problem, it is very likely that gossypol is a nephrotoxic agent. With 1 year of gossypol treatment, serum testosterone and serum luteinizing hormone showed no change, whereas serum follicle-stimulating hormone showed some elevation after 6 months. The Shanghai researchers found that in their gossypol users, plasma and urinary beta 2-microglobulin levels were elevated to a certain extent. However, 25 subjects in our 1983 to 1985 study showed no appreciable change. Our volunteers had stopped taking gossypol for more than 1 year. In 1986 we started a third study, which was aimed at finding the lowest antifertility dose to minimize possible renal toxicity.

Clinical Trials as Topic↗
PubMed1987

Clinical trial of gossypol as a male contraceptive drug. Part I. Efficacy study.

The main objective of the research is to study the effectiveness and safety of gossypol as a male contraceptive drug. Using a double-blind, randomized, controlled study design, gossypol was found to be an effective male antifertility drug, with no adverse effects on libido nor appetite. In terms of serum potassium levels, there were no statistical differences between gossypol and placebo groups at the end of the loading phase. However, through the ensuing 12 months of maintenance phase, a statistically significant trend toward reduced serum potassium level was evident.

Appetite↗
PubMed1987

Clinical trial of gossypol as a male contraceptive drug. Part II. Hypokalemia study.

A randomized controlled study was designed to evaluate the merit of whether ingesting potassium salt or potassium (K) blocking agent while using gossypol contraceptive drug could alleviate the symptom of hypokalemia. Results indicate that K salt supplementation did not reverse the gossypol-related hypokalemia and that the blocking agent triamterene did not prevent loss of or enhance the retention of serum K.

Blood Pressure↗
PubMed1980

Perinatal study in Tientsin: 1978.

Clinical records of a total of 3320 singleton births, representing the year 1978, at the two Tientsin Medical College Hospitals, Tientsin, People's Republic of China, were studied to ascertain (a) reproductive parameters such as the average age of the mothers at first and successive births and (b) the relationships between perinatal deaths, prematurity and birth weight and the mothers's age, number of previous pregnancies, parity, maternal conditions in the prenatal and delivery period and operative procedures of delivery.

Adult↗
PubMed1980

China's health system: determinants.

This paper seeks to examine and explain the changes in China's health policy since 1949. It attempts to clarify the role of various determinants in the health policy-making process in various stages of China's development and discover what forces propelled the shifts in health policies and campaigns. Various social, economic and political forces are discussed as they bear on the evolution of China's health policies, and the fate of Maoist vs. pragmatic tendencies is assessed.

China↗
PubMed1979

Contraceptive use-effectiveness and the American adolescent.

Contraceptive use-effectiveness is significantly shaped by the contraceptors' ages, for pregnancy rates are found to be a function of age. Teenagers are more failure prone than older contracepting women, regardless of method. This higher teenage failure rate can indicate clearly the use-effectiveness of various contraceptive methods. Consequently, both user and method (whether modern or traditional) determine outcome levels of contraceptive use-effectiveness.

Abortion, Induced↗
PubMed1975

Unusal signs and symptoms associated with oral contraceptive medication.

A review of medical literature concerning case history reports of adverse clinical manifestations of hormonal contraceptives is presented. While extremely rare, these side-effects often present with obscure etiology, and the physician is cautioned to be aware of their occurrence.

Adolescent↗