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Biomedical subjects

K C Ossoinig

Publications and source records attributed to K C Ossoinig.

15 recordsLinked to original sources
PubMed1992

Acute promyelocytic infiltration of the optic nerve treated by oral trans-retinoic acid.

BACKGROUND: Oral trans-retinoic acid has recently been shown to be an effective treatment modality for acute promyelocytic leukemia. This type of drug differs from traditional tumoricidal agents by promoting differentiation of the malignant, immature cells. METHODS: The authors describe a patient with optic nerve infiltration by acute promyelocytic leukemia documented ophthalmoscopically and confirmed by standardized echography and magnetic resonance imaging. High-resolution chromosome banding revealed the patient had a 15;17 chromosomal translocation known to be associated with acute promyelocytic leukemia. Treatment was instituted with oral all trans-retinoic acid without adjuvant radiotherapy or intrathecal chemotherapy. RESULTS: Results of serial bone marrow examination showed progressive differentiation of malignant cells with complete bone marrow remission. Results of serial ophthalmic examinations showed complete resolution of the leukemic optic nerve head infiltration. CONCLUSION: All trans-retinoic acid alone can be an effective treatment for optic nerve head infiltration in acute promyelocytic leukemia. This case suggests that radiation therapy may not be necessary in acute promyelocytic leukemia with optic nerve infiltration.

Administration, Oral↗
PubMed1979

Congenital mucocele of the lacrimal sac.

Two infants had congenital mucocele of the lacrimal sac. The diagnosis of this condition was aided by ultrasound. Congenital mucocele is one of the few indications for immediate lacrimal system probing in the neonatal period. Probing in both patients was successful.

Cysts↗
PubMed1977

Axial length changes after retinal detachment surgery.

A-scan echography was an accurate method for detecting changes in the depth of the anterior chamber, lens thickness, and length of the vitreous cavity after retinal detachment surgery in 30 eyes. Approximately 60% of the eyes had significant alterations in axial lengths exceeding+/-0.36 mm in aphakic eyes and +/-0.54 mm in phakic eyes. However, the operation of scleral bucklingg with large segments of hard silicone rubber implants or explants supported by an encircling band failed to result in a significant predictable shift of axial change in phakic or aphakic eyes. A-scan echography showed significant shallowing of the anterior chamber, and scleral buckling significantly increases lens thickness for at least six weeks. This induced a minor myopic refractive change that may explain some of the difference in postoperative refracitons between phakic and aphakic eyes.

Astigmatism↗
PubMed1975

Echographic detection and localization of BB shots in the eye and orbit.

BB shots and other spherical foreign bodies produce long chains of rapidly successive echo spikes which gradually decrease in height. These patterns are specific for this type of foreign bodies and allow their reliable detection and accurate localization. A-scan echography has become a very useful addition to X-ray examination in order to determine whether such foreign bodies are intra- or extraocular. Echography also helps to localize such foreign bodies during surgery and to evaluate the posterior segment of the eye in the presence of opaque ocular media (hemorrhages, cataract). Although it is sometimes possible to demonstrate specific B-scan patterns of spherical foreign bodies, A-scan echography is the method of choice since it is faster, more reliable and more accurate.

Evaluation Studies as Topic↗
PubMed1975

Cavernous hemangioma of the orbit. A differential diagnosis in clinical echography.

Cavernous hemangiomas of the orbit produce echographic A-scan patterns which allow their detection, localization, measurement, and differentiation from all other orbital lesions with a high degree of accuracy. Specific echograms, however, of these tumors can only be obtained with optimized and standardized A-scan instruments providing specific settings of the sensitivity, amplifier characteristics, dynamic range, expansion of the screen display, filtering, etc. When instruments other than these are used, both differentiation and detection of this tumor become difficult or impossible. The more an A-scan instrument differs from the optimized and standardized type, the less successful the diagnosis of cavernous hemangiomas becomes, B-scan techniques add to the A-scan examination by better demonstrating the round shape and the topographic relationship to the globe, the optic nerve and the orbital wall.

Blood Flow Velocity↗
PubMed1975

Ten-year study on clinical echography in intraocular disease.

During the past 10 years, clinical echography has been developed to a valuable and even indispensable examination method with which more than 25 various conditions and diseases or groups of lesions within the globe can be differentiated (the majority of them with a high degree of realiability and accuracy). Two signigicant steps to this end were the optimizing of both instrumentation and examination techniques as well as the standardization of the A-scan method. A few of the major conditions and diseases of the posterior segment of the globe, e.g. retinal detachments and retinoblastomas, are discussed in detail in this study, while ocular foreign bodies, malignant melanomas and other choroidal tumors and pseudo-tumors are discussed in two other studies presented in these proceedings (see pp. 109,141). At the end of this 10-year period, clinical echography, although quite mature, is still a very young examination method which can and will be further improved to an even more reliable and at the same time easier technique. Both A-and B-scan techniques are important for the diagnosis of intraocular diseases: the (standardized) A-scan method for a reliable detection as well as quantitative and kinetic evaluation, the B-scan technique for a better demonstration of the shape and topographic relationship of lesions in the vitreous and at the posterior pole.

Diagnosis, Differential↗
PubMedDate not supplied

Ultrasonic evaluation of salivary glands.

Diagnostic ultrasound was used to study 40 patients undergoing excision of a major salivary gland for various disease entities. Findings were as follows: Malignant lesions showed low reflectivity and attenuation with poorly outlined or diffuse borders. Inflammation demonstrated high reflectivity and attentuation with diffuse borders. Echographic patterns from mixed tumors showed either high or medium to low reflectivity; all demonstrated low to medium attenuation and were well outlined. It appears that various diseases of the major salivary glands have different echographic patterns. An attempt to correlate the echographic patterns with the histology of the disease process was made.

Adolescent↗