Biomedical subjects

K Chukanov

Publications and source records attributed to K Chukanov.

10 recordsLinked to original sources

PubMed1977

[Clinical morphological and immunological characteristics of lupus nephropathy].

Analysis is carried out of the clinical, pathomorphological and immunological characteristic of lupus nephropathy in 62 patients, 56 females and 6 males. A series of new investigation methods were used for that purpose. An early tendency towards kidney involvement in the course of LED is established and in 22 of the patients (36%) the renal symptoms have been the first clinical manifestations of the basic illness. Lupus nephropathy progresses most often with a nephrosis syndrome (in 66.1% of the patients), rarely pure and not combined with hypertension and/or with renal insufficiency. The pathomorphological changes are rather multiform but in the majority of the cases almost all structural elements of glomerules and the rest of the renal tissue are affected. The clinical picture severity, histopathological changes and nephropathy evolution course were established to be distinctly dependent on the course acuteness of the basic morbid process. The importance of the detailed study of the clinico-morphological and immune characteristic of lupus nephropathy upon the timely diagnosis. Proper treatment and the prognosis assessment of the illness is stressed upon.

Adult↗

PubMed1976

[Diagnosis of oligosymptomatic forms of chronic glomerulonephritis].

An investigation is carried out, by punch biopsy, on 54 patients with chronic glomerulonephritis, its course being evaluated as oligosymtomatic. From the patients followed up 35 were with morphologic changes corresponding to endoproliferative type, 13--to membranaceous type and 6--to membranaceous-proliferative type. The patients' complex investigation (incld. the investigation of biopsy renal material) was established to allow the disease diagnosis in its initial stage, irrespectively of the lack of manifested clinical and laboratory symptoms. Some typical peculiarities in the clinical course and the differences of the followed up laboratory indices, for separate morphologic types, were established and thus the diagnostic opportunities were increased. The duration of the oligosymptomatic course is also different, the highest being in the endoproliferative type--an aveagre of 10 years and the shortest--in the membranaceous-proliferative type--an average of 3 and 4 months. In the patients studied, in spite of the lack of manifested clinical and laboratory activity, a definite tendency is found towards gradual disease course with restricted renal functional potentialities. Besides on glomerulonephritis morphological type, this tendency depends on some additional factors as intercurrent diseases, keeping of no optimal regimen of life and labour, pragnancy etc. The authors are provided grounds to admit that early complex diagnosis specifying is a necessity in carrying out systematic prophylactic and therapeutic measures, thus improving the disease prognosis.

Biopsy, Needle↗

PubMed1976

[Serum haptoglobin and sialic acid content and the spontaneous rosette test values as indices of the activity of the disease process in chronic glomerulonephritis].

The diagnostic significance of haptoglobin is studied as well as of sialic acid and spontaneous rosette test (SRT) and ESR as indices of the morbid process activity in 74 patients with chronic hephritis with manifested and oligospymptomatic course and in a stage of therapeutic remission and in 14 patients with acute protracted nephritis. The parallelism of the changes in all parameters studied is proved in acute protracted nephritis and in chronic nephritis with manifested course. In patients with oligosymtomatically advancing chronic nephritis, in spite of the normal values of ESR and the rest of the routine indices for determination of the morbid process activity, haptoglobin, sialic acid and SRT were established to be increased. They were hardly normalized after the advancement of a lasting therpeutic remission. That all gives grounds to the authors to think, that the significance of the studied indices for the assessment of the morbid process activity in oligosymptomatically advancing chronic glomerulonephritis, is superior, to a certain extent, to the diagnostic signficance of ESR. Their follow up in dynamics permits their application in the determination of the immunosuppressive treatment efficiency.

Acute Disease↗

PubMed1974