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Biomedical subjects

K Cloete

Publications and source records attributed to K Cloete.

7 recordsLinked to original sources
PubMed2006

An outbreak of drug-resistant tuberculosis caused by a Beijing strain in the western Cape, South Africa.

During October 2005, four children in a school in Cape Town were identified with multidrug-resistant tuberculosis (MDR-TB). Genetic analysis confirmed that these isolates belonged to a single cluster (Beijing cluster 220) and that all harboured a -15 inhA(C-T) promoter mutation demonstrating transmission. Genetic analysis of isolates cultured from patients from the Boland-Overberg-South Cape-Karoo and Cape Town regions showed that 28% (58/209) of patients infected with a Beijing strain had the cluster 220 genotypes and that all harboured the same -15 inhA(C-T) promoter mutation. The presence of these transmissible MDR-TB strains may pose a threat to the community, and rigorous infection control measures are needed to ensure the safety of those exposed.

Bacterial Proteins↗
PubMed2005

Effect of an IMCI intervention on quality of care across four districts in Cape Town, South Africa.

AIMS: To measure the change in quality of care provided to sick children as a result of the routine implementation of the IMCI intervention. METHODS: Structured observations of consultations with sick children, exit interviews with caregivers, and facility reviews were conducted both before and after IMCI intervention in four health districts in Cape Town. Interventions were case management training, orientation courses for supervisors and medical officers, and some reorganisation of management systems. RESULTS: Twenty one nurses in 21 clinics were observed before and after the IMCI intervention; 90 and 70 child observations were conducted before and after IMCI intervention respectively. There was a marked improvement in assessment of danger signs in sick children (7% before versus 72% after), assessment of co-morbidity (integrated score 5.2 versus 8.2), rational prescribing (62% versus 84%), and starting treatment in the clinic (40% versus 70%). However there was no change in the treatment of anaemia or the prescribing of vitamin A or counselling of caregivers. There was no change in the knowledge of caregivers regarding medication or when to return to the health facility. Facilities were well stocked and supervision regular both before and after IMCI. CONCLUSION: This study has shown that under normal operating conditions and in a context of good facility infrastructure and management support, IMCI is associated with improvements in some important aspects of care.

Ambulatory Care↗
PubMed1993

[An electroglottographical analysis of certain voice parameters: normative indications].

A comprehensive voice evaluation comprises more than just the evaluation of perceptual and organic aspects. Objective voice analysis should supplement the diagnostic battery. In order to obtain normative indications for the Speech Research Laboratory at the University of Pretoria, 25 men and 25 women ranging in age from 8 to 80 years and with perceptually normal voices were tested with regard to fundamental frequency, cycle to cycle frequency fluctuation (jitter), cycle to cycle amplitude fluctuation (shimmer) and harmonic/noise ratio. Results indicate that these parameters are sensitive to changes in voice production caused by ageing, changes in loudness and the production of different vowels. The implications of these results for research and clinical practice are discussed.

Adolescent↗
PubMed1987

Medroxyprogesterone acetate in non-metastatic gestational trophoblastic disease.

The effect of medroxyprogesterone acetate (MPA: Depo-Provera, Upjohn) as a contraceptive agent was assessed in 45 patients with non-metastatic gestational trophoblastic disease and compared with 13 patients using hormonal and 26 patients using non-hormonal methods of contraception. In the whole group of 84 patients 18 (21.4%) required chemotherapy. There was no statistically significant difference in the incidence of persistent trophoblastic disease between MPA (9/45) and the oral contraceptive group (2/13) and MPA and the non-hormonal contraceptive groups (7/26).

Adolescent↗