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Biomedical subjects

K Corbett

Publications and source records attributed to K Corbett.

At least 37 records · Page 2Linked to original sources
PubMed1996

Women gain weight 1 year after smoking cessation while dietary intake temporarily increases.

OBJECTIVE: To examine the relationship of dietary change to weight change in women who quit smoking and remained abstinent for 1 year. METHODS: For 1 year, 582 women participating in smoking cessation classes were studied. Weight, diet, and physical activity were measured at baseline and at 1, 6, and 12 months after smoking cessation. Multivariate regression models were used to predict 1-year weight change for the 139 women who remained abstinent. RESULTS: Women gained, on average, 9.9 lb over a 1-year period while increasing their intake of energy for 1 and 6 months but returning to baseline levels by 1 year. Sucrose, total carbohydrate, and fat intake increased significantly for the first month; fat and total carbohydrate intake remained at an increased level for 6 months. In unadjusted analyses, older women and those who smoked more cigarettes gained more weight than younger women and lighter smokers; lighter and heavier women gained more weight than women of intermediate weight. In adjusted analyses, age remained a significant factor and number of cigarettes remained of borderline significance. Change in energy intake was predictive of weight change only in women with the highest energy intake at baseline. APPLICATIONS: Dietitians should acknowledge that most women who quit smoking gain weight in the short term. Although many women increase their energy intake, change in energy level is only one factor in weight change. Over the long term, women with high baseline intakes appear to be able to affect their weight change by reducing their energy intake.

Adult↗
PubMed1996

Durability of tobacco control activities in 11 north American communities: life after the Community Intervention Trial for Smoking Cessation (COMMIT).

Durability of tobacco control activities in the 11 intervention sites of the Community Intervention Trial for Heavy Smokers (COMMIT) was examined. Although continuation of COMMIT activities was not a major goal, all communities made plans to continue some tobacco control activity. Information was gathered at focus groups of former COMMIT volunteers and staff who were assembled in each community and asked to describe tobacco control activities in their communities during the past 12-16 months-the period after the termination of COMMIT funding. It was found that a tobacco coalition, board or other structure was still operating in nine of the 11 communities and 10 had some level of paid staff dedicated to smoking control. There was also substantial activity in three of the four channels that COMMIT used as an intervention framework: worksites, public education and cessation resources. Many communities were currently engaged in considerable smoking control activity aimed at youth, an area that was intentionally de-emphasized by COMMIT. Implications for the durability of health promotion programs by communities are discussed.

Adolescent↗
PubMed1995

Smokers' baseline characteristics in the COMMIT trial.

BACKGROUND: Baseline telephone survey data from 10 COMMIT sites were submitted to statistical analyses to compare the smoking characteristics of non-Hispanic white (white), non-Hispanic black (black), Mexican-origin (Mexican), and Puerto Rican-origin (Puerto Rican) smokers. RESULTS: White men and women were more likely to be classified as "heavy smokers" than members of other racial/ethnic groups, although black and Puerto Rican smokers were more likely than whites to increase their smoking rates on weekends. Whites were less likely to report stopping smoking in the past. White and Mexican smokers were most likely to smoke light or ultralight brands and least likely to smoke menthol cigarettes. Blacks were most likely to report smoking their first cigarette of the day within 10 min of waking. CONCLUSION: The differences and similarities among different groups of smokers may have important implications for understanding patterns of tobacco-related disease in smokers from different racial/ethnic and sex groups.

Adult↗
PubMed1995

A comparison of methods of predicting maximum oxygen uptake.

The aim of this study was to compare the results from a Cooper walk run test, a multistage shuttle run test, and a submaximal cycle test with the direct measurement of maximum oxygen uptake on a treadmill. Three predictive tests of maximum oxygen uptake--linear extrapolation of heart rate of VO2 collected from a submaximal cycle ergometer test (predicted L/E), the Cooper 12 min walk, run test, and a multi-stage progressive shuttle run test (MST)--were performed by 22 young healthy males (mean(s.d.) age 22.1 (2.4) years; body mass 72.4(8.9kg)) and the values compared to those obtained by direct measurement on a maximal treadmill test. All of the subjects were regular exercisers. The mean(s.d.) from the various tests in ml.kg-1.min-1 were as follows: treadmill 60.1(8.0), Cooper 60.6(10.3), MST 55.6(8.0), and predictedL/E 52.0(8.4). The Cooper test had a correlation with the treadmill test of 0.92, while the MST and the predictedL/E had correlations of 0.86 and 0.76 respectively. Both the MST and predictedL/E showed systematic underprediction of the treadmill value. On average, the MST was 4.5 ml.kg-1.min-1 (s.e. 0.9) lower than the treadmill VO2max while the predictedL/E was 7.8 ml.kg-1. min-1 (s.e. 1.4) lower than the treadmill VO2max. These findings indicate that, for the population assessed, the Cooper walk run test is the best predictor of VO2max among the three tests.

Adult↗
PubMed1993

Ethics and occupational therapy practice.

Professional ethics are guiding principles which are intended to orient the individuals within the profession, ensure our clients best interests and to protect the profession itself and its position in the public mind. Professional ethics are the rules we use to make certain that each therapist is operating in a fashion which protects the integrity of our profession and hence the viability of all occupational therapists. Our professional ethics, in addition to our special training and acquired skills, explain our profession to the health care community and those patients whom we serve. Professional ethics are a method by which our membership defines itself and guides its members throughout their career. Professional ethics ensure a place of trust within the Canadian health care system for those who choose to practice occupational therapy.

Canada↗
PubMed1993

Smoking cessation factors among African Americans and whites. COMMIT Research Group.

OBJECTIVES: This study was undertaken to explore smoking patterns and attitudes that influence smoking cessation and relapse among African Americans. METHODS: Baseline data from eight Community Intervention Trial for Smoking Cessation (COMMIT) sites were analyzed. RESULTS: Compared with Whites, African Americans who smoke less than 25 cigarettes per day were 1.6 times more likely to smoke within 10 minutes of awakening (a behavioral indicator of nicotine dependence), adjusting for education, age, and gender (OR = 1.2 for heavier smokers). African Americans reported a stronger desire to quit smoking and reported serious quit attempts in the past year. African Americans favored tobacco restrictions (they were 1.8 times more likely than Whites to view smoking as a serious community problem, 1.7 times more likely to favor restrictions on cigarette vending machines, and 2.1 times more likely to prohibit smoking in their car). African Americans were lighter/moderate, menthol smokers. CONCLUSIONS: African Americans find smoking socially unacceptable and are strongly motivated to quit, but their "wake-up" smoking may indicate high nicotine dependence, making abstinence difficult even for lighter smokers.

Adult↗
PubMed1993

A strategy to enhance skills. Developing intravenous therapy skills for community nursing.

1. Information abounds on teaching clients, partners and relatives about home i.v. therapy, but there is a lack of training for community nurses in this area. 2. Training for IV therapy has been difficult to develop in community settings, but must involve managers, specialists, and practitioners. 3. Community-led IV therapy training requires resources across acute and community sectors, with skills development through contract learning and focusing skills to specific practice contexts. 4. Training and experience in managing central venous access developed by community nurses are transferable to all clients and to other colleagues.

Community Health Nursing↗
PubMed1992

Worksite smoking control activities: prevalence and related worksite characteristics from the COMMIT Study, 1990.

BACKGROUND: There is a pressing need for current information on worksite smoking policies and stop-smoking activities. To address these needs and identify worksite characteristics associated with such activities, a computer-assisted telephone interview was administered to 793 worksites having at least 50 employees. METHODS: Within each of the 11 COMMIT intervention communities, attempts were made to survey 30 worksites within each of three size strata: 50-99 employees, 100-249 employees, and 250+ employees. Response to the survey was good, with a screening rate of 95% and a response rate of 90%. RESULTS: Overall, 69% of responding worksites reported having written smoking policies, but only 15% banned all indoor smoking. Smaller worksites and manufacturing and wholesale/retail companies were less likely than other organizations to be smoke-free or have representatives attend smoking policy workshops. Thirty-five percent of worksites reported offering smoking cessation resources or assistance for employees, but only 20% offered both cessation resources and restrictive or smoke-free policies. Smaller worksites as well as wholesale/retail sales and manufacturing worksites were less likely to offer cessation resources or to participate in community wide stop-smoking events. CONCLUSION: Although the level of worksite smoking control activities was higher than that reported in earlier surveys, there is still a substantial need to increase the level of such activities, especially at smaller worksites and in manufacturing and sales organizations.

Canada↗
PubMed1991

Drinking patterns and drinking-related problems of Mexican-American husbands and wives.

The present research builds on previous studies' findings of alcohol-related gender differences between Mexican-American men and women, through examination of drinking levels, norms and related problems within the context of marriage and family. A survey of husbands and wives in 206 married couples randomly selected from eligible households in East San Jose, California, was carried out. Highlights in our findings include significant gender differences in reports of drinking patterns, frequency of heavier drinking, tangible consequences of drinking and expectancies regarding alcohol. Most notably, correlations were found between husbands' and wives' quantity-frequency drinking measures, the frequency of heavier drinking, tangible consequences of drinking and expectancies regarding alcohol. Although men have higher levels of drinking and greater drinking-related problems, husbands' and wives' patterns are correlated with one another. These links between spouses' drinking-related variables have important implications for family prevention and education about alcohol use.

Acculturation↗
PubMed1991

Skeletal muscle metabolism in the offspring of trained rats.

To determine the effects of maternal exercise training during pregnancy on skeletal muscle metabolism of the progeny, eleven female Sprague-Dawley rats were divided into an exercise and a control group. The maternal training group (6) ran on a rodent treadmill for 4 weeks prior to pregnancy and daily throughout gestation (21 days) at 26.8 m/min, 1 hour/day, 5 days per week. The measurements were taken 28 days postpartum. No differences were noted between the sedentary and trained maternal animals for succinic dehydrogenase (SDH), phosphofructokinase (PFK), and myosin ATPase activities of the soleus, plantaris and gastrocnemius muscles. Maternal gastrocnemius SDH and soleus PFK levels were significantly (p less than 0.05) lower than levels found in the offspring. The liver glycogen of trained maternal animals was significantly higher than that found in all other groups. As well it was shown that maternal exercise had no effect on any of the aforementioned physiological parameters measured in the pups. The results indicate that exercise training during pregnancy does not modify the skeletal muscle metabolism of the offspring as observed 28 days after birth.

Adaptation, Physiological↗
PubMed1987

Quantitative estimate of bilaterally projecting medial olivocochlear neurones in the guinea pig brainstem.

Bilateral intracochlear injections of the fluorescent retrograde neuronal tracers fast blue and diamidino yellow were used to identify efferent neurones in the guinea pig brainstem which project to the inner ear on both sides. Bilaterally projecting neurones, detected by their double-labelled appearance in fluorescence microscopy, were found in all the nuclei of origin of the large neurone extra-LSO system of olivocochlear neurones. No double-labelled neurones were found in the small neurone LSO system. When precautions were taken to maximize their capture, these bilaterally projecting neurones comprised 5.4% of the total extra-LSO system neurones projecting to any one cochlea. On the basis of these quantitative data, it was suggested that the bilaterally projecting neurones may correspond to the small group of binaurally activated cochlear efferents identified in physiological studies.

Amidines↗
PubMed1981

Structure and function of the murine muscle-tendon junction.

The muscle-tendon junctions of the extensor carpi radialis longus and brevis muscles from adult Balb C Bailey/J mice have been examined tensiometrically and ultrastructurally following removal of cellular membrane and soluble cytoplasm by exposure to nonionic detergent. As judged by the ability of the extracted muscle to generate tension upon exposure to ATP and to transmit the generated tension to the tendon, detergent extraction leaves the muscle-tendon junction functionally intact. Electron microscopic analysis of the extracted muscle-tendon junctions reveals that the relationship between the terminal myofilaments and the lamina densa of the basal lamina is retained, despite the extensive extraction of the plasma membrane. Fine filaments (2-7 nm) are seen to connect the lamina densa with an electron-dense intracellular layer into which terminal actin filaments appear to insert. These fine filaments are considered to represent an important component of the structural linkage between myofilaments and connective tissue and hence to be a significant component of the tension transmitting mechanism. Their precise nature is not known, but some part of the filaments must pass through the hydrophobic compartment of the plasma membrane and thus must be a transmembrane component of considerable tensile strength. These studies suggest that detergent-extractable membrane lipids play no significant role in the transmission of tension at the muscle-tendon junction, and that fine filaments, probably protein, are responsible for transmitting tension from myofilaments, through the plasma membrane, to the lamina densa of the basal lamina.

Animals↗
PubMed1975

Metabolism of the germinating sclerotium of Claviceps purpurea.

The concentration of free amino acids, particularly alanine, altered as stromata developed on germinating sclerotia. Lipid reserves in the sclerotium provided the principal carbon and energy source, and the nutrients required for stomatal growth appeared to be provided by the sclerotial tissues immediately beneath the point of attachment of the stoma. Alkaloid did not disappear from the sclerotia during germination. Very high levels of polyol, particularly mannitol, were attained in the stromata as germination progressed; the synthesis of polyol was usually accompanied by that of soluble sugars, notably glucose. In an attempt to ascertain the role of mannitol in germination, the relationship between polyol and soluble sugars was investigated in excised stromata after their submergence in buffered media containing a variety of soluble carbohydrates. Mannitol was synthesized under these conditions by way of phosphorylated intermediates, and chiefly in the capitulum, after rapid, and probably passive, absorption of the exogenously supplied sugar. The tissues equilibrated rapidly with the supplied carbohydrate, whose concentration was maintained by further uptake whilst mannitol was being synthesized. The concentrations of assimilated glucose and synthesized mannitol tended toward the same value during incubation and the results suggested that the synthesis was compartmentalized within the stromata. Very little exogenously supplied mannitol was assimilated.

Alanine↗
PubMed1973

Biosynthesis of ergotamine by Claviceps purpurea (Fr.) Tul.

High-yielding strains of Claviceps purpurea (Fr.) Tul, grown on a defined medium, have been used for a study of the biosynthesis of the peptide ergot alkaloid, ergotamine. l-[U-(14)C]tryptophan, dl-[2-(14)C]mevalonic acid lactone, sodium [2-(14)C]acetate, sodium [(14)C]formate and the methyl group of l-[methyl-(14)C]methionine were efficiently incorporated into the peptide alkaloids and specifically labelled the ergoline moiety of ergotamine. These results are the same as previously found for the biosynthesis of other ergot alkaloids. Time-course incubation experiments demonstrated that l-[U-(14)C]phenylalanine, l-[U-(14)C]proline and l-[U-(14)C]alanine were incorporated into the peptide ergot alkaloids. Chemical degradation of the radioactive alkaloid derived from additional precursor incubation experiments showed that phenylalanine and proline function as the most efficient precursors, and specifically label the constitutive side-chain phenylalanyl and prolyl moieties of the alkaloid. The evidence obtained from l-[U-(14)C]alanine-incorporation experiments was inconclusive. However, degradation of ergotamine isolated after incubation with dl-[1-(14)C]alanine, showed that the carboxyl group of the labelled amino acid was specifically incorporated into the alpha-hydroxy-alpha-amino acid residue of the alkaloid. This, in conjunction with the l-[U-(14)C]alanine-incorporation results, showed conclusively that all three carbon atoms of alanine were incorporated as a biosynthetic unit into the alpha-hydroxy-alpha-amino acid moiety of ergotamine.

Acetates↗