Biomedical subjects

K D Bhat

Publications and source records attributed to K D Bhat.

3 recordsLinked to original sources

PubMed1982

Volume-adjusted maximal mid-expiratory flow (Iso-volume FEF25-75%): definition of "Significant" responsiveness in healthy, normal subjects.

Iso-volume FEF25-75% was evaluated in 30 non-smoking, healthy subjects (16-58 years) to define the percentage change over baseline required for responsiveness to inhaled bronchodilators using this measurement to be significant. The mean percentage change from baseline for Iso-volume FEF25-75% was 15.3% +/- 17.2% (1 SD). Improvement of greater than 49.6% (mean +/- 2 SD) over baseline is required for the change reflected by the Iso-volume FEF25-75% to be significant.

Adolescent↗

PubMed1982

The clinical significance of volume-adjusted maximal mid-expiratory flow (Iso-volume FEF25-75%) in assessing airway responsiveness to inhaled bronchodilator in asthmatics.

The clinical significance of Iso-volume FEF25-75% in assessing airway responsiveness to an inhaled bronchodilator was evaluated in 167 asthmatics who presented with variable degrees of airway dysfunction. Iso-volume FEF25-75% identified responsiveness in one patient (5%) out of 20 of the most dysfunctional asthmatics, in three (20%) out of 15 of the least dysfunctional asthmatics and over-all in four (8%) out of 47 asthmatics not showing significant responsiveness via the FEV1. Over-all, FEV1 identified significant responsiveness in more patients (68.6%) than did the Iso-volume FEF25-75% (61%). The authors conclude that the Iso-volume FEF25-75% adds little to the FEV1 in the assessment of obviously dysfunctional asthmatics, the FEF25-75% as conventionally measured is a relatively useless post-bronchodilator measurement and that the FEV1 remains the single best spirometric test with which to assess airway responsiveness in asthmatics.

Administration, Intranasal↗

PubMed1981

A classification system for asthmatic patients: clinical-physiological correlation.

A classification system for asthmatics based on simple, readily available clinical tools is defined and evaluated. Asthmatics so classified differed significantly in terms of their degree of dysfunction at the time of presentation. Comments regarding the relative importance and proper perspective of pulsus paradoxus and retraction of the sternocleidomastoid muscle in each classification of asthmatics is made.

Adolescent↗