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Biomedical subjects

K D Charalampous

Publications and source records attributed to K D Charalampous.

At least 19 recordsLinked to original sources
PubMed2001

Insights into physician retirement.

Most physicians in this study retired because they thought the time was right, and they did not feel forced to do so. This situation may not be the case in the future with changes occurring in the practice of medicine. Most of the physicians were pleased with their retirement after they had completed an adjustment period, often lasting about a year. The most important factor involved in successful retirement was the health of the physician and his or her spouse. A good relationship with the spouse was important. Typically, relationships with spouses improved. If a physician has no spouse or poor spousal support, some other method of replacing the support network previously provided by staff, patients, and practicing colleagues is necessary. After retirement, the physicians in our study became comfortable with living on their savings. Strategies employed after retirement were diverse. Many of the retired physicians took advantage of increased time to exercise for enjoyment and for health. Although some of the retired physicians continued to pursue medical interests, many others discovered rewarding activities away from medicine, but rarely for financial compensation.

Adaptation, Psychological↗
PubMed1984

Double-blind placebo-controlled multicenter evaluation of the efficacy and safety of nomifensine in depressed outpatients.

Outpatients with primary affective disorder-depression who scored at least 20 on the Hamilton Depression Rating Scale (HDRS) were randomly assigned to treatment for 1 month with nomifensine (100-200 mg/day) or placebo. Clinical laboratory and physical evaluations, including ECGs when feasible, revealed no clinically significant changes over the course of treatment. Nomifensine patients showed improvement compared to placebo on the HDRS total score endpoint analysis (p = .06) and the Cognitive Disturbance and Retardation factors (p less than or equal to .05). A better rate of improvement was seen with nomifensine on the Clinical Global Impressions severity of illness (p less than or equal to .05) and therapeutic index (p less than or equal to .05) components. No differences were seen between groups in the incidence of overall or specific side effects. Nomifensine thus appeared safe and superior to placebo on several key measures of depressive symptomatology in this multicenter study of depressed outpatients.

Administration, Oral↗
PubMed1978

Major side effects of antipsychotic drugs.

Since the introduction of phenothiazines into clinical practice in 1952, over 250 million people have received these drugs for the treatment of psychotic states. In addition to the phenothiazines, five other classes of neuroleptic medications are now in use: butyrophenones, thioxanthenes, dihydroindolones, diphenylbutylpiperidines, and dibenzoxazepines. Besides their use in the treatment of psychosis, these drugs have been used in the treatment of anxiety, depression, nausea, alcoholic withdrawal, and pain, and are often administered in combination with other medications. Through the use of these drugs, many psychotic patients have been able to move back into the community, and the family physician is coming into contact with more patients on maintenance dosages of neuroleptics. He/she may wish to prescribe these drugs or may, in the treatment of a medical problem, need to prescribe other medication to an individual already receiving neuroleptics. It is important, therefore, for the family physician to be aware of the side effects of these drugs and of complications which can arise when neuroleptics are given in combination with other families of drugs.

Butyrophenones↗
PubMed1977

Cerebellar cAMP levels following acute and chronic morphine administration.

Acute administration of morphine sulfate at 20 mg/kg decreased mouse cerebellar adenosine 3',5'-cyclic phosphate (cAMP) levels while not affecting cAMP phosphodiesterase (EC 3.1.4.17). The cAMP levels and cAMP phosphodiesterase activies were not affected by chronic treatment. However, cAMP levels increased during abrupt withdrawal both with and without naloxone precipitation, with cAMP phosphodiesterase activities being correspondingly decreased. Propanolol prevented the cAMP increase during abrupt withdrawal.

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMed1977

Alcoholism and the courts: experience with a traffic safety project.

The authors describe a federally funded Alcohol Safety Action Project in Texas that attempted to change the drinking behavior of individuals arrested for driving while intoxicated. The project was one of more than 35 around the nation designed to deal with the problem of the drinking driver; unlike many others, its primary emphasis was on rehabilitation. The project functioned as a self-supported ancillary agency to the probation department; however, because of problems in coordination with the legal system, it had access to only about a fourth of the DWI offenders. Despite that drawback, and the inability to prove the value of the projects by the federal evaluation criteria initially set, the authors believe that the experience in Texas has demonstrated the advantages of combining the efforts of the judicial and the health-care systems to deal with alcohol abuse.

Accidents, Traffic↗
PubMed1976

Self-esteem in alcoholics and nonalcoholics.

Alcoholics scored lower on a test of self-esteem than did nonalcoholics, Alcoholics with lower self-esteem were found to be more willing to seek treatment than those with higher self-esteem.

Adult↗
PubMed1975

Item analysis of the Michigan Alcoholism Screening Test.

The Michigan Alcoholism Screening Test was administered to 200 persons arrested for driving while intoxicated. Most items adequately discriminated between problem and nonproblem drinkers, but several questions assessing severe alcoholism symptoms did not consistenly differentiate between the 2 groups.

Adult↗