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Biomedical subjects

K D Glass

Publications and source records attributed to K D Glass.

5 recordsLinked to original sources
PubMed1982

Factors related to the resolution of treated hand infections.

One hundred thirty-eight patients with acute hand infection (81% deep) treated from 1970 to 1980 in hospital were reviewed. Resolution time of infection was slow, 8 days or longer in 57% of 135 patients and 15 days or longer in 28%. Such slow resolution occurred in infection of closed anatomical spaces and included 50% of all pulp space and joint infections, 23% of tenosynovitis, and 24% of subcutaneous dorsal had infections. There was a direct correlation between increasing treatment delay and slower resolution of infections in pulp spaces, palmar spaces, joints, and tendon sheaths. If the mean treatment delay was greater than a brief 2 1/2 days, 69% of tenosynovitis showed delayed resolution. Other factors associated with the rate of resolution were adequacy of surgical drainage, efficacy of antibiotics, and associated diabetes mellitus.

Acute Disease↗
PubMed1980

Using expanded polytetrafluoroethylene for bridging arterial microvascular defects: an experimental study with evaluation in the scanning electron microscopy.

In an experimental investigation the replacement of arterial microvessels with microporous expanded polytetrafluoroethylene was studied. The infrarenal segment of the rat aorta was used as the scientific model. The inside diameter of the micrograft was 1 mm. Using microvascular techniques a total of 18 prostheses were inserted. The animals were harvested at time intervals from 3 days up to 3 months. Patency was determined by angiography and at autopsy. The aorta implant junction, the characteristics of the neointima development and the differentiation of the interstitial cells were studied by scanning electron microscopy. Fourteen of the implanted micrografts remained patent at the time of sacrifice, yielding an early patency rate of 77,7%. As shown by scanning electron microscopy, the development of the neointima took place in 2 stages. The initial fibrin/platelet layer was reduced after one month and replaced by a definite neointima with mononuclear cells, connected with interstitial cells. Investigation of the aorta-implant junction showed the prosthesis functionally embedded in the structure of the aorta. Expanded polytetrafluoroethylene as a prosthetic material for microvascular prostheses was easy to handle and emerged compatible with other tissues. It can be used as a substitute for bridging arterial microvascular defects.

Animals↗
PubMedDate not supplied

Bone disease in primary biliary cirrhosis: increased bone resorption and turnover in the absence of osteoporosis or osteomalacia.

The role of vitamin D in hepatic osteodystrophy was examined. Eleven unselected patients with primary biliary cirrhosis (PBC) were assessed for disorders of mineral and vitamin D metabolism. Six were not receiving supplementary vitamin D, and five were being treated with oral vitamin D (50,000 IU daily). Serum levels of 25-hydroxyvitamin D were normal in all patients receiving oral therapy and in 4 of 6 untreated patients. Levels of serum 1,25-dihydroxyvitamin D and 24,25-dihydroxyvitamin D were normal or near normal in all patients. Studies were repeated after 6 months of therapy with parenteral vitamin D2 (100,000 IU i.m. monthly) in 7 patients. Initial bone histomorphometry revealed no evidence of osteomalacia or osteoporosis. However, the bone resorption surface of trabecular bone was increased. This abnormality was no longer present on repeat bone biopsies obtained after parenteral vitamin D therapy, and bone formation had decreased. In addition, trabecular bone volume remained normal in the face of the lower rate of bone formation. Increased bone resorption surface in the absence of osteoporosis or osteomalacia has not been previously described in PBC. Improvement in this bone parameter, associated with the finding of a decrease in the formation of bone and in hydroxyproline excretion in urine after parenteral vitamin D, suggests that increased turnover may be an early feature of the bone disease which complicates PBC and that parenteral vitamin D may retard the rate at which hepatic osteodystrophy develops in chronic cholestatic liver disease.

Adult↗
PubMedDate not supplied

Anterior tibial compartment syndrome associated with ergotamine ingestion.

This is the first reported case of acute anterior tibial compartment syndrome following ergotamine tartrate overdosage. A 25-year-old man developed signs and symptoms of ergotism after ingestion of 72 mg of ergotamine tartrate over the 12 days prior to his hospital admission. On the fourth hospital day, the patient developed bilateral anterior tibial compartment syndrome. The development of this syndrome is postulated to have been due to the progressive edema and tissue pressure in the anterior tibial compartments, worsened by the gradual improvement of the peripheral circulation which followed the diminished vasopastic effect of the ergotamine.

Adult↗