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Biomedical subjects

K D Hay

Publications and source records attributed to K D Hay.

12 recordsLinked to original sources

Propolis allergy: a cause of oral mucositis with ulceration.

Propolis has been used since ancient times in folk medicine for its alleged beneficial effects. It is a potent sensitizer and is well recognized as a cause of occupational allergic eczematous contact dermatitis in apiarists. Recently, there has been an increase in allergic eczematous contact dermatitis because of nonoccupational exposure to propolis in "natural products" and biocosmetics. This report describes a patient who had acute oral mucositis with ulceration as a result of using propolis-containing lozenges.

Aged

Photogrammetry used to assess post-operative facial swelling in a drug trial.

A trial was designed to test the efficacy of ibuprofen in controlling post-operative pain and swelling following the surgical removal of lower third molar teeth. Because of the rigid criteria imposed on the trial it was not satisfactorily completed but the method of measuring the volume of the swelling by stereometric photogrammetry, which is reproducible, versatile and non-invasive, was considered to be worth reporting in context.

Adolescent

The use of an elimination diet in the treatment of recurrent aphthous ulceration of the oral cavity.

The involvement of components of food in the causation of recurrent aphthous ulceration of the oral mucosa is controversial. To test the proposition, seventeen patients with RAU which had been resistant to other forms of treatment were studied with the aid of a strict elimination diet. Five patients abandoned the difficult diet, and of the remaining twelve there were five patients who had remission of RAU while on the diet. In four of these five patients a particular food was identified which, when eliminated from the normal diet, led to either marked improvement or resolution. The results of this study clearly indicate the participation of food components in the etiology of some cases of RAU .

Adult

Allopurinol-amplified lichenoid reactions of the oral mucosa.

Three cases of oral lichenoid reaction linked with the administration of allopurinol are presented. Withdrawal of the drug resulted in considerable clinical improvement in one case and complete resolution of the ulcerative lesions in the other two cases. The consideration of drug-induced reactions in the differential diagnosis of oral mucosal diseases has been emphasized.

Allopurinol

Lichen planus: a theory of pathogenesis.

From a continuing study of 108 cases of oral mucosal lichen planus, including so-called drug-induced lichenoid reactions, the response of patients to topical therapy and to drugs implicated in inducing the lichenoid reactions was used to construct a hypothetical model regarding the pathogenesis of the condition. The results were interpreted to indicate that lichen planus is a predetermined condition or diathesis, perhaps genetically based, rather than a simple cause-and-effect disorder.

Adolescent

D-penicillamine-induced mucocutaneous lesions with features of pemphigus.

Penicillamine (beta1 beta2 dimethylcysteine) is the drug of choice in the therapeutic management of Wilson's disease and cystinuria and has been used in the treatment of some heavy-metal intoxications. Recent studies have shown that it is efficacious in patients with rheumatoid arthritis. Side effects include sensitivity reactions, nephrotoxicity, bone-marrow suppression, hypogeusia, skin lesions, and the formation of autoantibodies. Two cases are described with the features of pemphigus which were attributed to penicillamine therapy.

Aged