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Biomedical subjects

K D Kuhl

Publications and source records attributed to K D Kuhl.

At least 19 recordsLinked to original sources

The influence of military low-altitude flight noise on the inner ear of the guinea pig. Part I: Hearing threshold measurements.

The auditory thresholds of about 60 anaesthetized guinea pigs were determined at 3 or 4 frequencies between 2 and 20 kHz using the acoustically evoked brain stem potentials. The animals were then exposed to electro-acoustically reproduced MLAF noise with peak levels between 120 and 130 dB(A). The exposure occurred either once or else four times within either 3 or 60 minutes. The level of noise increased at 7.5 and 75 dB/s (slow and fast increase). TTS was then determined. PTS was measured one week later. In over half the animals, exposure to rapidly increasing noise level with a peak of 126 dB(A) induced PTS > or = 30 dB for at least one frequency. Exposure to a slowly increasing noise level with the same peak provoked significantly smaller PTS. 4 exposures to a rapidly rising noise level within 3 minutes induced significantly smaller PTS than the same dosage within 60 minutes. Only in the latter case was PTS greater than TTS.

Aerospace Medicine↗

Guinea pig cochlear blood flow under definite sound exposure-hydrogen clearance measurement.

Blood flow measurements were carried out on 18 coloured guinea pigs (8 animals served as control group) before and during definite sound exposure (12 kHz, 110 dB SPL). The exposure time amounted to 60 min. The anaesthesia was carried out according to the following schedule: a mixture consisting of 70 mg alpha-chloralose/kg b.w. and 400 mg urethane/kg b.w. was injected intraperitoneally. The relaxation was performed by means of i.p. application of 3 mg Tricuran/kg b.w./h. The hydrogen clearance measurements (HCM) were carried out under artificial respiration with control of arterial pH, endexpiratory CO2 content, as well as blood pressure and body temperature. After a duration of noise exposure of 30-45 min the cochlear blood flow reached an average level of 80% of the initial point. This level remained mainly unchanged until the end of noise exposure (60 min). Our HMC's confirm Laser Doppler flowmetry findings.

Acoustic Stimulation↗

[The activity and capacity of the inner ear (author's transl)].

The inner ear is an energy converter and a biochemical amplifier. The normal function of the stria vascularis and the organ of Corti is bound exclusively to the respiratory metabolism. Some but not all species are equiped by a glycolytic reserve metabolism for preservation of the sensory cells, as could be improved in amplitude-time-curves of cochlea microphonics in hypoxic conditiones. A promising therapy of inner ear disturbances following short timed oxygen deficiency depends on the moment of the treatment.

Animals↗