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Biomedical subjects

K D Morley

Publications and source records attributed to K D Morley.

At least 19 recordsLinked to original sources
PubMed1995

Treatment of vasculitic leg ulcers in connective tissue disease with iloprost.

Leg ulcers are a recognised manifestation of cutaneous vasculitis in connective tissue diseases (CTDs) including rheumatoid arthritis (RA). Iloprost a stable prostacyclin analogue has been successfully used to treat Raynaud's phenomenon and digital ulcers associated with CTD's. Our aim was to assess iloprost in the treatment of vasculitic leg ulcers in CTD. In this paper we describe eight cases of vasculitic leg ulceration in association with RA and CTD, treated with intravenous iloprost. The iloprost was administered for 6-8 hours daily and continued for 21-28 days. Immunosuppressive therapy was required in three patients with severe necrotising vasculitis (RAnv). Complete ulcer healing was achieved in four patients within 6 weeks of commencing therapy while rapid improvement occurred in the other four patients. This suggests that iloprost may be useful as an adjunct to therapy for vasculitic leg ulcers. A double-blind placebo controlled study of iloprost therapy for RA leg ulcers is under way.

Aged↗
PubMed1992

Astrocytoma presenting with vasculitis.

A cerebral astrocytoma which had remained quiescent possibly for 12 years, presented with blackout, vasculitis and a lupus-like (L-E like) syndrome. The association between tumours and "L-E like" syndromes is reviewed briefly.

Adult↗
PubMed1985

Penicillamine-induced ocular myasthenia gravis.

Two patients with rheumatoid arthritis (two women, 58 and 62 years old) developed reversible penicillamine-induced ocular myasthenia gravis. Both had the HLA-DR1 antigen, unlike most patients with idiopathic myasthenia gravis who show HLA-DR3, suggesting that penicillamine-induced myasthenia gravis and its idiopathic counterpart occur in patients with different genetic backgrounds. In both cases, cessation of drug treatment led to resolution of the symptoms.

Eye Diseases↗
PubMed1984

Left ventricular function in patients with ankylosing spondylitis and Reiter's disease.

We have studied left ventricular function by non-invasive methods in 28 patients with ankylosing spondylitis and 14 with Reiter's disease and compared them with 42 normal subjects. A dilated and poorly contracting left ventricle with abnormal systolic time intervals were found in five (18%) of those with ankylosing spondylitis and two (14%) with Reiter's disease. Our results suggest that the high cardiovascular morbidity and mortality in these diseases may be due to abnormality of the myocardium in the absence of valve disease.

Adolescent↗
PubMed1984

A comparative trial of a controlled-release formulation of ketoprofen ('Oruvail') and a conventional capsule formulation of ketoprofen ('Orudis') in patients with osteoarthritis of the hip.

An open study was carried out in 46 patients with osteoarthritis of the hip to compare the efficacy and tolerance of treatment with ketoprofen given either as 100 mg capsules twice daily or as 2 capsules of 100 mg ketoprofen in a controlled-release formulation given once daily. The results of subjective and objective assessments before and during 3-months' treatment in the 48 patients who completed the trial showed both treatments produced improvement in all parameters, except for the time taken for inactivity stiffness to develop, and there was no significant difference between treatments in terms of efficacy. The controlled-release preparation, however, was significantly better tolerated than the ordinary capsule form. Minor haematological and biochemical changes during treatment were noted but these were not of clinical importance. Six patients, 2 receiving the controlled-release and 4 receiving the ordinary formulation of ketoprofen, were withdrawn because of lack of efficacy or unacceptable side-effects.

Adult↗
PubMed1983

Sarcoid dactylitis.

Dactylitis is a rare rheumatological complication of sarcoidosis. It may be accompanied by underlying bone changes, and management is often difficult. We report these 4 cases of dactylitis in which there have been significant bone changes and associated management problems. One case is further complicated by biopsy-proved sarcoid synovitis, uncommon in a British resident, and 2 cases show destructive bone changes, which have rarely been reported in sarcoidosis.

Adult↗
PubMed1983

An unusual cause of arthritis.

We present a case of leprosy, an uncommon infection in the United Kingdom, which mimicked features of widely known rheumatic diseases and resulted in subsequent delay of diagnosis.

Adult↗
PubMed1983

Sex hormones in male patients with systemic lupus erythematosus: a comparison with other disease groups.

There is substantial evidence for alteration of oestrogen metabolism in both males and females with systemic lupus erythematosus (SLE). Low testosterone levels have been described in men with SLE, and it has been suggested that this may be a further predisposing factor to the development of the disease. Serum testosterone, oestradiol, FSH and LH levels were measured on two or more occasions in nine male patients with SLE. Similar estimations were performed on four other groups for comparison: ten male patients with rheumatoid arthritis, six male patients on long-term steroid therapy, eleven male patients with renal failure on long-term haemodialysis and eleven healthy male volunteers. Mean testosterone levels were significantly reduced in all disease groups and there was no significant difference between patients with SLE and those with other chronic disorders. Oestradiol levels were normal in all groups, but there was a trend to elevated mean levels of FSH and LH (p 0.05 for the haemodialysis group). Our results confirm that testosterone levels are low in males with SLE, but suggest that this is an effect of chronic disease, and therefore unlikely to be a pre-existing risk factor for the development of SLE in men.

Arthritis, Rheumatoid↗
PubMed1982

Systemic lupus erythematosus: two patients treated with danazol.

Two women with systemic lupus erythematosus who showed premenstrual flaring of the disease were treated with danazol, which resulted in clinical improvement.This form of treatment needs to be assessed more widely, as there is little reported evidence that hormonal regulation has therapeutic value in systemic lupus erythematosus.

Adult↗
PubMed1982

Lupus foot.

Explore the source record for details and available documents.

Adult↗
PubMed1981

Deep venous thrombosis after total hip arthroplasty: a prospective controlled study to determine the prophylactic effect of graded pressure stockings.

Graded pressure stockings significantly reduced the incidence of venographically determined deep venous thrombosis (DVT) after total hip arthroplasty. Seventy-six patients were studied; the incidence of DVT was 54 per cent in 41 control patients and 20 per cent in 35 patients who wore stockings. Administration of blood during the operation and in the first 24 h after operation, if given in excess of blood loss, was associated with a significantly increased risk of developing DVT. The application of graded pressure stockings and the avoidance of unnecessary perioperative blood transfusion are worth while in the management of total hip arthroplasty.

Aged↗
PubMed1979

Verapamil in the management of hypertensive patients.

The hypotensive action of verapamil given orally was assessed in the outpatient management of patients with raised blood pressure, in a single blind study. Twenty-six hypertensive patients on no therapy, 14 on beta blockers and eight on methyldopa were more satisfactorily controlled when verapamil was substituted for the initial drug. There was a marked reduction in the number of side-effects, and the drug was given in many situations where beta blockade was contra-indicated.

Adrenergic beta-Antagonists↗
PubMed1978

The treatment of hypertension with verapamil.

In a randomised double blind cross over trial, verapamil produced significant dose dependent reductions in blood pressure in 23 patients. There were minimal side-effects. All patients had some contraindication to the use of beta blocker therapy, and the role of verapmil in this situation is discussed.

Adult↗