Relationship between nutrition and bone growth in large and giant dogs.
The pathogenesis of the osteochondrosis syndrome was studied in large and giant breeds of dogs. Spontaneous cases of osteochondrosis were examined in large breed dogs, and experimental disease was investigated in Great Dane puppies fed ad libitum or restricted diets until 6 mo of age. This investigation concluded that the primary lesion occurring in osteochondrosis of dogs from the large and giant breeds is an acquired pattern of osteopenic and biomechanically weak subchondral spongiosa that cannot provide adequate bony support for the articular cartilage of joints. Excessive biomechanical loading of the inadequately supported epiphyseal articular cartilage leads to secondary disturbances in the nutrition, metabolism, function and viability of the chondrocytes in the developing joint surface. The primary lesion in the subchondral spongiosa develops when overnutrition (ad libitum feeding) overstimulates skeletal growth and cancellous bone remodelling mechanisms in those breeds of dogs who already have an inherent capacity for rapid skeletal growth. The epiphyseal spongiosa of rapidly growing dogs of the larger breeds is inherently less dense and less strong per unit area than epiphyseal spongiosa of dogs from the smaller breeds. Overnutrition in dogs from the larger breeds exaggerates this tendency to create osteopenia by increasing the rates of skeletal growth and remodeling of the newly formed cancellous bone. Accelerated rates of bone growth and bone remodeling act in concert to product a pattern of epiphyseal spongiosa that is composed of fine trabecular systems that are spaced relatively far apart and that are ultimately less strong per unit area than in small breeds of dogs.(ABSTRACT TRUNCATED AT 250 WORDS)