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K Dahm

Publications and source records attributed to K Dahm.

At least 37 records · Page 2Linked to original sources
PubMed1976

[Experimental study on the pathogenesis of anastomotic ulcers (author's transl)].

Various forms of operative duodenal exclusion with or without duodenogastric reflux were performed on 54 male Wistar rats. It was demonstrated that after duodenal exclusion with reflux peptic ulcers regularly occur at the site of anastomosis. Continuous reflux of bile and pancreatic secretion is the decisive factor in the development of ulcer at the anastomotic border between stomach and jejunum. Stasis in the excluded duodenum (syndrome of the afferent loop) promotes the ulcerogenic reflux effect. If there is no pylorus, reflux and stasis are potentiated to the highest incidence of ulcer (more than 90%). These results indicate that operations with duodenal exclusion and reflux (Billroth II) should be discontinued.

Animals↗
PubMed1976

Ossification in cancer of the stomach: an experimental study.

In rats with Nitrosoguanidine induced carcinomas of the gastric stump, heterotopic ossifications are found freqently. The following stages of differentiation during the desmal ossification in the stump carcinomas are demonstrated: 1. Osteoblasts, 2. Osteoid, 3. Woven bone, 4. Lamellar bone. --The islands of metaplastic bone cells are predominantly located in the invasive marginal zone of the carcinoma of the gastric stump. The histology of the heterotopic ossification in the gastric stump of the rat is similar to that one seen in stomach cancer of men. The model here described seems to be suitable for further study of metaplastic bone formation in the gastrointestinal tract.

Adenoma↗
PubMed1976

Susceptibility of the resected stomach to experimental carcinogenesis.

The purpose of this study was to find whether gastric resection enhances the incidence of carcinoma in the remaining part of the stomach. 66 male Wistar rats were subjected to stomach resection according to the Billroth I or the Billroth II method. These rats, as well as control animals with intact stomachs, were fed the carcinogen N-Methyl-N'-nitro-N-nitrosoguanidine (NG). -- 25 of 66 animals developed carcinomas in the gastric remnant. Precancerous lesions were seen in 18 rats. The tumours were characterized histologically as adenocarcinomas. They were almost exclusively localized in the region of the gastroenteral anastomosis. The process of tumour formation in the resected stomach was completed within 17-31 weeks on continuous administration of NG in a concentration of 120 mg/l in the drinking water. In contrast to these findings, the development of cancer in the intact stomach required on average 41 weeks under the same conditions of NG administration. However, with regard to the incidence of malignant changes, no significant difference was observed between animals undergoing the Billroth I method and those undergoing the Billroth II method.--The results suggest that the resected stomach of the rat is more susceptible to induction of cancer than the intac one. Exposure of the resected stomach to an oral carcinogen induces carcinogenesis predominantly in the anastomotic region.

Adenocarcinoma↗
PubMed1976

[Stenoses of the small and large bowel following radiotherapy of female genital cancer (author's transl)].

Stenoses of the lower intestinal tract following radiotherapy of female genital cancer occur at a frequency of 2-5%; the terminal ileum as well as the sigma are often involved. From 1966-1976 110 patients were treated at the Department of Surgery of the University Hospital of Hamburg. 43 patients required surgical treatment; stenosis of the sigma was the most frequent indication followed by ileus of the small intestines, haemorrhagic proctitis, ulcer of the anterior rectal wall and vesico-recto-vaginal fistula. The following operations were performed: Resection of the small intestines or enterolysis (n = 11), resection of the descending colon (n = 8), abdominal perineal excision of the rectum (n = 4), transversostomy (n = 14) and fistula plastics. - From our experience, intestinal reactions after radiation must be suspected when 1. the total irradiation dose is over 6000 R, 2. radium implants are used, 3. previous operations and abdominal inflammatory lesions restrict the movement of the intestines.

Aged↗
PubMed1976

[Gastrointestinal anastomoses and carcinoma in the operated on stomach].

This study examines the question of which type of gastroenteral anastomosis is predisposed to carcinoma of the gastric stump. Evaluation of operative or autopsy reports of 72 patients with carcinomas of the gastric stump following ulcer resection was undertaken. The interval after resection for ulcer was on the average 23 years. In 69 cases a Billroth II resection with retrocolic anastomosis (Polya type) had been performed; 7 patients had a Billroth II resection with enteroanastomosis (Braun's type); only 3 cases of Billroth I resection were found in the whole collective. From the results it may be concluded that carcinoma of the gastric stump develops predominantly in the remaining stomach following Billroth II resection with retrocolic anastomosis (without Braun's enteroanastomosis). When retrocolic anastomosis is performed, the duodenogastric reflux definitely passes through via atrophic gastritis to the development of a stump carcinoma. However, when Billroth I resection or Billroth II resection with enteroanastomosis is performed, the duodenogastric reflux is low or is quantitatively derived into the jejunum.

Adult↗
PubMed1975

[Duodenal reflux and gastritis after Billroth I gastric resection (author's transl)].

Endoscopic and biopsy studies were undertaken in 92 patients who had undergone partial gastric resection (end-to-end gastroduodenostomy, Billroth I) one to seven years previously. In addition, the amound of duodeno-gastric reflux was evaluated by measuring bromsulphalein excretion in gastric juice. Atrophic gastritis occurred in 36%, while superficial gastritis was noted in 49% of patients. The degree and severity of the inflammatory changes was most marked near the anastomosis. The severity of the duodenal gastric reflux was decisive in the development of the atrophic mucosal changes. There was no demonstrable relationship between the degree of mucosal changes and the interval since the operation.

Atrophy↗
PubMed1975

[Heterotopic ossification in cancer of the stomach. An experimental contribution to a clinical phenomenon (author's transl)].

Heterotopic ossifications are found frequently in rats with nitrosoguanidine-induced carcinomas of the gastric stump. The following steps of differentiation of the desmal ossification in the stump carcinomas are demonstrated: 1. Osteoblasts. 2. Osteoid. 3. Woven Bone reticular network. 4. Lamellar bone. The islands of metaplastic bone cells are predominantly located in the invasive marginal area of the carcinoma of the gastric stump. The histology is similar to that one seen in stomach cancer of men. Therefore, the here described model seems to be suitable for further study of the metaplastic bone formation in the gastrointestinal tract.

Animals↗