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Biomedical subjects

K Dankó

Publications and source records attributed to K Dankó.

10 recordsLinked to original sources
PubMed1992

[Changes in the activity of natural killer cells in superficial bladder cancer during intravesical BCG therapy].

Alteration of natural killer (NK) activity from the peripherial blood was examined in the patients with superficial bladder cancer during two years between 1989-1991. The natural killer cell activity in patients with superficial bladder cancer was significantly depressed that activity was found in normal controls (P less than 0.01). 23 patients received intravesical BCG immuntherapy and NK activity was detected in the same patients 72 times in different period during the therapy. The authors decided that the activity of NK cells alters in BCG therapy. Increase of NK cells activity in the most common way of this alteration but many different type of this change is possible. The lower dose BCG (120 mg) often induce augmentation of NK activity but high dose BCG (200 mg) more frequently caused depressed activity of NK cells. The authors didn't find direct connection between therapy effect and NK activity but they found significantly less NK activity (P less than 0.03) in the patients who are in relapse. According to their opinions the role of natural killer cells in the antitumor effect of BCG can not be excluded. They recommended more immunological investigations to clear up the anticancer effect of BCG immuntherapy.

Administration, Intravesical↗
PubMed1991

Effects of suramin on phagocytes in vitro.

In the therapeutically important range (100-200 micrograms/ml), suramin was found to increase the phagocytic activity of human monocytes (measured by the uptake of Saccharomyces cerevisiae and sensitized sheep red blood cells) in vitro. Suramin itself was a chemotactic signal for monocytes and increased the chemiluminescence of neutrophil granulocytes. Suramin seems to act via the ATP-binding P2 receptors of human phagocytes.

Adenosine Triphosphate↗
PubMed1988

Function of monocytes in patients with systemic sclerosis.

Functions of monocytes from the peripheral blood of 23 patients with systemic sclerosis were investigated in vitro. The yeast phagocytosis, opsonized yeast phagocytosis and binding of EA (erythrocyte-antibody) particles were found to be normal. A depressed chemotactic response was demonstrated against a zymosan-activated, complement-derived chemotactic factor. In 12 cases, monocytes were cultured for 168 hours. By the 5th and 7th days, the initially depressed chemotactic activity of monocytes returned to normal as compared to controls. This fact supports the speculation that the decreased chemotaxis cannot be caused by an intrinsic abnormality of monocytes/macrophages in systemic sclerosis.

Adult↗
PubMed1987

Polymorphonuclear neutrophil function in systemic sclerosis.

In vitro functions of polymorphonuclear (PMN) neutrophils were studied in 20 patients with progressive systemic sclerosis (PSS). An increase in the basal chemiluminescence (CL) activity of peripheral blood PMNs was found, suggesting that these cells had been preactivated in vivo. Patients with more extensive skin disease or signs of disease progression tended to have higher basal CL values. Active oxygen products during the respiratory burst may increase the extent of inflammatory and fibrotic processes and could be involved in the endothelial injury in PSS. The stimulatory capacity of CL response was normal in our study. No alterations were found in the opsonised yeast phagocytic activity of granulocytes when compared with control values. The binding of erythrocyte-antibody particles was found also to be normal. A depressed chemotactic activity of PMN cells against zymosan activated serum was also shown. The cause of the decreased chemotaxis of PMNs remains to be elucidated.

Adult↗
PubMed1985

Lymphocyte markers in patients with progressive systemic sclerosis.

18 patients with progressive systemic sclerosis were investigated. An absolute lymphopenia and a decrease in the number of E-rosettes and early E-rosette forming cells were found. The number of T gamma cells was reduced as compared to the control values. No diminution was found in the number of histamine receptor bearing cells but the number of T lymphocytes capable of recognizing autologous red blood cells was considerably decreased. The number and the ratio of these T cell subpopulations remained relatively stable even after 6 months in the patients with progressive systemic sclerosis. No individual correlation was found between the clinical findings and the ratio of T cell subpopulations.

Adult↗
PubMed1985

T lymphocyte subpopulations in progressive systemic sclerosis defined by monoclonal antibodies.

Twenty two patients with progressive systemic sclerosis were studied by monoclonal antibodies to detect OKT4 and OKT8 positive cells. The absolute number of OKT4 and OKT8 cells was not altered as compared to control values. The ratio of T4/T8 cells slightly increased without statistical significance. The number of E-rosette forming T-cells was reduced in patients with progressive systemic sclerosis. Six months later 11 patients were reinvestigated, and similar results were obtained for the T-cell subsets and the ratio of T4/T8 positive cells. Individual data showed marked variability in the two periods of investigation without however, any correlation to the clinical findings. The sclerodermic patients had a long disease duration and showed no immunoregulatory T-cell imbalance.

Adult↗
PubMed1977

Radioassay of soluble immune complexes using their uptake by macrophage Fc receptors.

Sera from patients were tested for the presence of soluble immune complexes (IC) by a method based on the observation that IC inhibit uptake of aggregated IgG by the Fc receptors of macrophages. From the saturation curve of macrophages with 125I-labelled aggregates the optimal inhibitory effect of a measured amount of IC was determined. This radioassay is highly sensitive, being capable of detecting 20 ng of IC, is reproducible and covers a wide range of measurement (20-2000 ng).

Antigen-Antibody Complex↗
PubMedDate not supplied

Progressive systemic sclerosis occurring in patients exposed to chemicals.

Eight patients with systemic sclerosis previously exposed to organic chemical agents were investigated. Laboratory and clinical data of these patients were evaluated. The interval between the beginning of exposition and symptoms was 6.1 +/- 4.9 years. Considering the laboratory findings, a slight decrease in OKT4 positive T cell number was found. The antinucleolar and fine speckled antinuclear antibody pattern was found simultaneously in five cases. The possible role of chemical agents in the development of sclerodermic changes is discussed.

Adult↗