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Biomedical subjects

K Date

Publications and source records attributed to K Date.

51 records · Page 3Linked to original sources
PubMed1989

Familial occurrence of anomalous pancreaticobiliary duct union associated with gallbladder neoplasms.

The authors present two cases of anomalous pancreaticobiliary duct union that occurred in a mother and her daughter; the former was associated with gallbladder adenocarcinoma, and the latter, gallbladder adenoma with high grade dysplasia. This disorder has been considered a developmental anomaly, although the true etiology has not been known. This is the first report of familial occurrence of this anomaly, and it may point to the presence of a genetic factor in its development. Another implication is the presence of histological features which suggest the possible sequence of anomalous pancreaticobiliary duct union to intestinal metaplasia to adenoma or dysplasia to cancer of the gallbladder.

Adenocarcinoma↗
PubMed1979

Scanning electron microscope studies on the synovial membrane.

Synovial membranes from human and rabbit joints were observed by scanning electron microscopy. 1. The surfaces of synovial membranes present locally variable appearances. In some parts cytoplasmic processes of lining cells extend long and flat causing an appearance like overlapping renal podocytes, whereas in other parts the cells protrude in cauliflower-like or more smooth-surfaced round bodies. 2. In cracked surfaces of synovial membranes, two types of lining cells are distinguished. One is the cell which has more surface processes and numerous granules in the cytoplasm, the other is the cell which has fewer processes and better developed endoplasmic reticulum without granules. 3. Fibroblasts apparently forming collagen fibers are observed in the subsynovial tissue. Two types of fibrogenesis are found. In the first type microfibrils seem to be formed extracellularly, whereas in the second type bundles of filaments are preformed in the cytoplasm and they appear to be extruded directly from the cell surface.

Adolescent↗
PubMedDate not supplied

Suppression of T lymphocyte proliferation by peritoneal macrophages in chickens.

The mechanism of the suppression of lymphocyte proliferation by peritoneal macrophages (MPs) in chickens and the presence of a suppressive substance in the culture supernatant of MPs were studied. The results showed that gelatin- and peptone-induced peritoneal MPs had an inhibitory accessory function against blastogenesis of mitogen-stimulated splenic lymphocytes and that resident peritoneal MPs had an enhanced accessory function. The suppressive factor produced by gelatin-induced peritoneal MPs is a protein having a pI of 3.6 and a molecular weight of 64,000 and it is physically and chemically a relatively stable substance. Moreover, it has no cytotoxic effect against lymphocytes and it was verified that the suppressor in the culture supernatant of MPs was not prostaglandin E2 or alpha-acid glycoprotein.

Animals↗
PubMedDate not supplied

Major hepatectomy combined with pylorus-preserving pancreatoduodenectomy for middle bile duct cancer with multiple lymph node metastases: a case report of 5-year survival.

Hepatopancreatoduodenectomy has been well established as an aggressive surgical approach for advanced biliary tract malignancy. However, long-term survival of more than 5 years after this operation is rarely reported, especially with bile duct carcinoma. We report herein a 64 year-old man with middle bile duct cancer who underwent extended right hepatectomy combined with pylorus-preserving pancreatoduodenectomy because of widespread intramural extension of the tumor. Resection margin, which is considered the most significant prognostic parameter, was made clear only by additional hepatectomy in this case. In addition, although microscopic examination revealed multiple lymph node involvement up to the superior mesenteric node, the patient has survived 5 years and 6 months without tumor recurrence. It remains unclear whether aggressive lymph node dissection may improve surgical outcome; however, it is thought that surgical clearance of potentially involved nodes and tissue may be the only chance for long-term survival.

Adenocarcinoma↗
PubMedDate not supplied

Asymptomatic adenomyoma of the common hepatic duct discovered during a medical checkup: report of a case.

Although adenomyoma of the gallbladder is not so rare, adenomyoma arising in the bile duct is extremely rare. We herein report a case of partial biliary obstruction due to adenomyoma of the common hepatic duct. A 64-year-old woman was referred to the 1st Department of Surgery, Niigata University School of Medicine for surgical intervention, in whom a biliary stricture in the common hepatic duct was discovered incidentally during a medical check-up for hyperamylasemia in an affiliated hospital. She was asymptomatic without jaundice. Based on her past history of abdominal contusion, the insidious presentation and the smooth biliary stricture on cholangiography, a diagnosis of benign biliary stricture secondary to blunt abdominal trauma was made. A suspicion of malignancy, however, could not be ruled out. Subsequently, she underwent a resection of the extrahepatic bile duct with lymph node dissection in the hepatoduodenal ligament. The patient's postoperative course was uneventful. She was discharged 18 days after the operation. Histology of the resected specimen confirmed the diagnosis of adenomyoma in the common hepatic duct. Clinicians should note to avoid overlooking or misdiagnosing that adenomyoma is a cause of biliary obstruction, although extremely rare.

Adenoma↗