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Biomedical subjects

K Dressler

Publications and source records attributed to K Dressler.

8 recordsLinked to original sources
PubMed1988

[The biotransformation of propiverin hydrochloride (Mictonorm)].

Propiverine hydrochloride [1; hydrochloride of O-n-Propyl-(N-methylpiperidinyl-4)-benzilate; Mictonorm] is metabolized after p.o. application of 25 mg/kg on rats almost completely. Besides of small amounts of unchanged 1 in urine were detected the phase-I metabolites N-methylpiperidinyl(4)-benzilate (2), 2,2-diphenyl-5-methyl-1, 4-dioxan-3-on (3), N-oxide of 2 (4), benzilic acid (5) and O-n-propylbenzilic acid (6) using ms, dc and hplc comparison of the isolated compounds with authentic samples. The structure of further metabolites, i.e. monohydroxy-benzophenone (7), acetoxy-1-derivatives (8) and ethylbenzilate (9) were elucidated by high resolution MS.

Animals↗
PubMed1987

[Morphology of syncytiotrophoblast cells in testicular tumors].

Syncytiotrophoblastic cells were identified in a teratocarcinoma of the testis by light microscopy using the semi-thin sectioning technique. An electron microscope study confirmed them to be syncytial. Many irregularly shaped nuclei lying in a honeycombed cytoplasm were observed, while the free margins contained microvilli. These cells are morphologically similar to syncytiotrophoblasts of the normal placenta. The presence of syncytiotrophoblastic cells in testicular tumours means a worse prognosis than would otherwise be concluded on the basis of the particular tumour concerned.

Chorionic Gonadotropin↗
PubMed1986

[Analysis and stability of propiverine hydrochloride (Mictonorm)].

In acid, neutral and alkaline solution the hydrolytic degradation of the spasmolytic agent Mictonorm (1) was determined. As degradation products ester- and/or ether fragments (2-5), benzophenone (6) and a compound X (7) were identified. In comparison N-Methylpiperidinyl(4)-benzilate (2) and benzilic acid (3) were also investigated in the isothermal quick-assay test. The test showed that the ether bound in 1 was hydrolyzed before the ester group. The compounds 5-7 are formed also direct from 3.

Benzilates↗