Biomedical subjects
Publications and source records attributed to K E Harper.
Frey's syndrome is a form of gustatory hyperhidrosis that develops following surgery, trauma, or disease of the parotid gland area. Several theories have been proposed to explain the resulting symptomatology. Treatment often is difficult or ineffective. An unusual case is presented involving a patient with delayed onset of symptoms who responded well to topical application of 20% aluminum chloride in anhydrous ethyl alcohol.
Nevus comedonicus (NC) is an uncommon condition consisting of grouped comedo-like papules. Rarely, NC is associated with other structural abnormalities and diseases. Lesions of the palms or soles are distinctly unusual. Histopathologic findings support the concept of a developmental abnormality of the dermal components of the pilosebaceous apparatus with subsequent imperfect differentiation of the epidermal components. Therapy is often unrewarding, although topical tretinoin may be of value.
Direct GC-MS of succinic and glutaric anhydrides has been investigated, and shown to be feasible. In the GC-MS determination of deuterium in succinic anhydride, an isotope memory effect was observed, shown to be due to strong adsorption of solute onto the column. This phenomenon was investigated, together with possible methods for its suppression. Succinate TMS ester also was found to be a suitable derivative for direct GC-MS of deutero-succinic acid.