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K E Hobler

Publications and source records attributed to K E Hobler.

8 recordsLinked to original sources
PubMed2001

Applying data mining techniques to the mapping of complex disease genes.

The simulated sequence data for the Genetic Analysis Workshop 12 were analyzed using data mining techniques provided by SAS ENTERPRISE MINER Release 4.0 in addition to traditional statistical tests for linkage and association of genetic markers with disease status. We examined two ways of combining these approaches to make use of the covariate data along with the genotypic data. The result of incorporating data mining techniques with more classical methods is an improvement in the analysis, both by correctly classifying the affection status of more individuals and by locating more single nucleotide polymorphisms related to the disease, relative to analyses that use classical methods alone.

Chromosome Mapping↗
PubMed1986

Colon surgery for cancer in the very elderly. Cost and 3-year survival.

Is colon cancer surgery justified in the very elderly from the standpoint of cost and 3-year survival rates? Two hundred eighty patients undergoing major surgery for colon cancer during 1981-1983 were divided into a group of 61 with ages greater than or equal to 80 (GE80) and 219 less than 80 (LT80). Although those GE80 had higher median lengths of stays (18 vs. 15 days, p = 0.013) and hospital charges ($7845 vs. $6414, p = 0.002) than those LT80, there was no difference 3-year survival curves (Mantel-Cox p = 0.7155). Proportional Hazards Linear Model (multivariate) analysis showed that the risk of mortality could be predicted by disease stage (p less than or equal to 0.0001) or type of operation required (p less than or equal to 0.0001) but not by age group (p = 0.4552). It is concluded that surgery for colon cancer in the very elderly is justifiable and should not be restricted on the basis of age alone.

Age Factors↗
PubMed1985

Surgery in the very elderly.

The very elderly who underwent major surgical procedures had longer hospital stays and higher total charges than the younger age group in the majority of DRGs studied. Higher mortality rates in the very elderly for most of the DRGs were found to be associated with emergency surgery for conditions that carry very high mortality rates when surgery is not performed. Surgery in the very elderly, then, although from 30% to 40% more costly in terms of hospital days and charges, should not be withheld on the basis of age alone. Careful assessment of risks to each individual patient should be continued and can result in acceptable mortality rates.

Aged↗