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K E Isom

Publications and source records attributed to K E Isom.

12 recordsLinked to original sources
PubMed1979

Age differences and stress ulcer in the rat.

Rats 2-, 7- and 12-mo. old were exposed to supine body restraint plus cold (5 degrees C) for 3 hr. The mean cumulative length of lesions for the 2-, 7-, and 12 mo. old rats was 22.0, 43.0 and 16.0 mm. respectively. The same experimental design was used in a second study, but the pylorus was ligated prior to restraint. Total acid output/hr. was 134.6, 178.2, and 64.7 muEq/60 min. respectively for the three age groups. Older rats were not more susceptible to stress-ulcer and gastric acid was not significantly related to degree of ulceration.

Aging↗
PubMed1979

Comparison of pyloric ligation and pyloric cuff techniques for collecting gastric secretion in the rat.

A comparison was made between two methods for collecting gastric secretion in the rat. The two included a pyloric ligation technique and a snare-type pyloric cuff which was surgically implanted 2 weeks before the collection was initiated. It was hypothesized that the surgical trauma associated with pyloric ligation would inhibit gastric secretion and thus yield smaller gastric samples with this procedure as compared to the cuff technique. No differences in volume of gastric secretion or total acid output were observed between the two methods.

Animals↗
PubMed1977

Preparation of a chronic gastric fistula in the rat.

A stainless steel gastric cannula was surgically implanted in the rat forestomach to allow gastric secretion to be collected continuously without restraining the animal. When gastric collections were not being made, the cannula was closed with a plugging screw. Rats with these cannulas were easily maintained without special care or complications for 12 months.

Animals↗
PubMed1975

Gastric secretion as a function of acute and chronic stress in the gastric fistula rat.

In Experiment 1 rats exposed to signaled and unsignaled grid shock secreted more gastric acid after shock stress (chronic stress) for 8 days compared to the first 12 hr. of shock stress (acute stress). However, Experiment 2 indicated that the higher gastric acid values under chronic stress were not significantly greater than prestress baseline values. The results are interpreted to reflect an inhibition of gastric acid secretion as a function of acute stress. During chronic stress this inhibition is followed by a habituation of gastric secretory processes which is observed as a return of secretion volume to baseline levels.

Animals↗