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Biomedical subjects

K E Krantz

Publications and source records attributed to K E Krantz.

15 recordsLinked to original sources
PubMed1991

Abdominal-retroperitoneal sacral colpopexy for the correction of vaginal prolapse.

Complete genital or vaginal prolapse affects a large number of middle-aged to elderly females. Satisfactory correction of prolapse with maintenance of vaginal patency has been a challenge to the pelvic surgeon for many years. We present a retrospective review of 147 patients undergoing abdominal sacral colpopexy using dacron graft or expanded polytetrafluoroethylene. The anatomical basis of repair, operative technique, and results are described. Ninety-three percent of the patients experienced long-term success over 5 years, including those with previous failed repairs. Both short- and long-term complication rates were acceptable. Only four patients experienced graft erosion, and only one of those had recurrent prolapse. Abdominal sacral colpopexy offers those affected with genital prolapse an opportunity for long-term relief, with maintenance of a patent vagina.

Abdomen↗
PubMed1981

The carbon dioxide laser in cervical intraepithelial neoplasia: a five-year experience in treating 230 patients.

Two hundred and thirty patients with cervical intraepithelial neoplasia were treated over a 5-year period with the carbon dioxide laser at the University of Kansas. Analysis of cytologic findings, biopsy results, location of the lesion, treatment factors, and recurrence rates are reported. Ninety percent of the patients were cytologically free of intraepithelial neoplasia at the end of the study.

Carbon Dioxide↗
PubMed1979

Lysophosphatidic acids. Influence on platelet aggregation and intracellular calcium flux.

Decanoyl-, palmitoyl-, and oleoyl-lysophosphatidic acid (LPA) were studied for their effects on platelet aggregation and intracellular calcium flux. Palmitoyl-LPA and oleoyl-LPA both caused a concentration-dependent aggregation of human blood platelets at concentrations of 12--300 microM. Aggregation by adenosine diphosphate (ADP) was enhanced at slightly lower concentrations. First-wave aggregation induced by these LPAs was not blocked by aspirin, indomethacin, or heparin, suggesting similarities to ADP aggregation. However, in washed platelets with a high calcium concentration, no serotonin secretion was observed, even though full aggregation occurred, suggesting that aggregation was not due to released ADP. This concept was supported by studies of platelets deficient in the storage pool of ADP and serotonin, which had a normal first-wave aggregation response to palmitoyl-LPA. Aggregation induced by palmitoyl LPA was inhibited by prostaglandin E1 (PGE1), theophylline, and ethylenediaminotetraacetate (EDTA), though in the presence of EDTA shape change occurred. Aggregation stimulated by palmitoyl-LPA or oleoyl-LPA was characterized by changes in the shape of the platelets with development of pseudopods and centralization of granules closely surrounded by contractile microfilaments and supporting microtubules. The addition of palmitoyl-LPA and oleoyl-LPA, but not decanoyl-LPA, caused the release of calcium from a platelet membrane fraction that contains elements of the intracellular calcium storage system and actively concentrates this cation in the presence of adenosine triphosphate (ATP) and magnesium. It is suggested that LPAs cause aggregation by stimulating the release of calcium intracellularly.

Adenosine Diphosphate↗
PubMed1978

Treatment of cervical intraepithelial neoplasia with the carbon dioxide laser beam. A preliminary report.

Forty-five patients with histologically proved cervical dysplasia or carcinoma in situ were treated by the carbon dioxide-laser method. The carbon dioxide laser induces cell vaporization by causing intracellular steam combustion stimulated by the emission of a mixture of carbon dioxide, nitrogen, and helium. This method of treatment is easily performed in the outpatient clinic without anesthesia, is inexpensive, and is effective in the treatment of cervical intraepithelial neoplasia. The treatment allows preservation of the transformation zone, thus permitting future colposcopic visualization.

Adult↗