Biomedical subjects

K E Morehead

Publications and source records attributed to K E Morehead.

3 recordsLinked to original sources

PubMed1996

Uniform billing data in hospital planning, marketing and clinical guidelines.

Hospitals are major users of inpatient discharge data from the Pennsylvania Health Care Cost Containment Council (PHC4). A hospital planning and marketing executive and a hospital network consultant describe different uses for the data; including planning, competitor analysis, and development of clinical pathways. The PHC4 data are useful because they are reported in a uniform format for all facilities and they provide detailed clinical and financial information. In addition, Pennsylvania's data include an admission severity measure to permit risk adjustment. These data have enabled these institutions to enhance their clinical and financial performance.

Critical Pathways↗

PubMed1993

An improved microassay for Plasmodium falciparum cytoadherence using stable transformants of Chinese hamster ovary cells expressing CD36 or intercellular adhesion molecule-1.

Stable transformants of Chinese hamster ovary (CHO) cell lines expressing high levels of human CD36 or intercellular adhesion molecule-1 (ICAM-1) have been produced as target cells for cytoadherence of Plasmodium falciparum-infected erythrocytes. An improved adherence microassay has been designed using small sample volumes and allowing convenient and reliable measurements on a large number of samples. The assay can be used both with purified proteins spotted on plastic and with the stably transformed CHO cell lines. The same assay plate can be evaluated either microscopically or by scintillation counting after use of 3H-hypoxanthine-labeled parasites. Using the microassay, functional expression of the transfected receptor molecules on CHO-CD36 and CHO-ICAM was confirmed using parasites with different cytoadherence phenotypes and cytoadherence inhibition experiments with a panel of anti-CD36 antibodies. The use of isolates from The Gambia confirmed the applicability of these assays for laboratory studies of these isolates.

Amino Acid Sequence↗

PubMedDate not supplied

Language deficiency in children.

Research in cognition and language has provided useful constructs which suggests that specific deficits underlie language deficiencies in children. In addition, this research has provided procedures that the determine what a child knows about language at a particular level of development and has established a sequence of linguistic development that maps the specific content and structure of training programs. Two new areas of research offer additional approaches to assessment and remediation. One approach focuses on the actual principles and strategies that normal children use to learn language, making it possible to determine which methods are most efficient. The second research approach looks at the contextual conditions adults and children provide the first language learner. Preliminary work suggests that the natural conditions found universally in first language learning may be the best indicators of how to proceed with language-deficient children.

Child↗