Lack of human papillomavirus DNA in carcinoma cuniculatum.
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Carcinoma, Verrucous↗
Biomedical subjects
K E Sjølin
Publications and source records attributed to K E Sjølin.
Accessory urethra in a male. Case report.
A 19-year-old man presented with an unusual accessory urethra located on the shaft of the penis. The diagnosis was stated by biopsy.
Adolescent↗
Urinary excretion patterns of pseudouridine and beta-aminoisobutyric acid in patients with tumours of the urinary bladder.
The preoperative and postoperative values of urinary pseudouridine:creatinine (phi:C) and beta-aminoisobutyric acid:creatinine (beta AIB:C) were estimated, in 192 patients with urothelial tumours of the bladder, 92 of whom had not previously been diagnosed. Urinary phi:C ratio correlated with the grade of tumour cell dysplasia (being highest in dysplasia grade 3), and to a lesser extent with the clinical stage. The treatment had no major influence on the excretion ratios. Decreased ratios, or those within the reference range, were associated with a better prognosis than increased ratios, and if both were increased at the same time the risk for progression of the disease was high. The biological tumour markers pseudouridine and beta-aminoisobutyric acid may be helpful in the diagnosis of tumours in the upper urinary tract, and in the follow-up of patients with tumours of the bladder.
Adult↗
Primary Paget's disease of the penis. Case report.
A 64-year-old man presented to the dermatology clinic with primary genital Paget's disease. He was treated conservatively and died of metastases nine years later. The natural history of the lesion is malignant, and radical excision is recommended.
Biomarkers, Tumor↗
Squamous cell metaplasia of the bladder urothelium. A retrospective study of 36 patients.
In a retrospective study of 28 women and eight men with squamous cell metaplasia in different parts of the bladder, including the trigone, no histopathological differences were observed among the regions. All the five (female) patients with parakeratosis had a concomitant invasive bladder tumour. Thirty-eight% of all the patients had a simultaneous neoplastic tumour. The metaplastic lesions were investigated for keratin in 13 patients, and all were positive. In seven out of eight patients, the urothelium adjacent to the squamous cell metaplasia was also positive for keratin, indicating a direct transformation of the urothelium to squamous cell epithelium. The metaplastic cells were investigated for oestrogen receptors in five men and five women, and all were negative, suggesting no relationship between estrogens and squamous cell metaplasia of the bladder. Squamous cell metaplasia in the bladder is not considered a premalignant condition. However, metaplasia and neoplastic tumours are often associated with chronic tissue damage, and the presence of metaplasia may give a warning of conditions that can also cause cancer.
Adult↗
Pseudouridine and beta-aminoisobutyric acid excretion in urine: diagnostic and prognostic value.
The sex- and age-related urinary excretion of pseudouridine/creatinine and beta-aminoisobutyric acid/creatinine was studied in 77 healthy subjects (24 children and 53 adults, 27 of whom were women). The highest values were found in the youngest children. We compared the excretion ratios of pseudouridine/creatinine and beta-aminoisobutyric acid/creatinine in women and men and found no significant differences between them. The excretion patterns may be helpful in the diagnosis of patients with urinary tract tumours and in predicting patients at risk of recurrences.
Adolescent↗
Excretion patterns of pseudouridine and beta-aminoisobutyric acid in patients with tumours of the upper urinary tract.
In 39 patients with either pelvic or renal cell tumours, the pre-operative urinary excretion ratios of pseudouridine/creatinine (psi:C) and beta-aminoisobutyric acid/creatinine (BAIB:C) were estimated. In 34/39 of the patients (87%), including both types of tumours, psi: C was found to be increased, and in only one patient was the value decreased. Twenty-five of the patients (64%) had a BAIB:C ratio within the normal range. 10 (25%) had increased and 4 (11%) decreased values. In 13 patients the psi:C and BAIB:C ratios from the affected side were compared with the values in urine from the bladder. Twelve of the patients had higher values of psi:C in the urine from the ureter. In seven patients the ureteric BAIB:C ratio was higher than the bladder BAIB:C ratio and in five patients the ureteric BAIB:C ratio was less than the bladder BAIB:C ratio. In only one patient were the values similar. The results indicate that patients with tumours of the upper urinary tract have changed excretion patterns compared with normal subjects and the urinary ratios on the affected side are different from those on the healthy side. The biological tumour markers pseudouridine and beta-aminoisobutyric acid may be helpful in the diagnosis of tumours in the upper urinary tract.
Adult↗
Urothelial metaplasia of the bladder mucosa. Nephroid-colonic- and signet-ring cell metaplasia.
Three different types of metaplasia of the urinary bladder are described: nephroid metaplasia, colonic metaplasia and signet-ring cell metaplasia. The latter metaplasia was without any histological signs of malignancy and the patient is still alive without recurrence, 12 years after the diagnosis was made. We believe it is the first published case of benign signet-ring cell metaplasia. The patients with nephroid metaplasia were controlled from 3-18 months without recurrence. Two of the patients with colonic metaplasia were followed from 16 to 132 months; both developed recurrences. In patients with metaplasia of the urothelium, follow-up cystoscopy is recommended because of the recurrent nature of the condition and the malignant potential of metaplastic urothelium.
Aged↗
A comparative study of transitional cell tumors of the bladder and upper urinary tract.
In two groups composed of 228 patients with bladder tumors and 37 patients with upper urinary tract (UUT) tumors, we compared the transitional cell carcinoma in respect to sex, age, grade of dysplasia, staging, and survival. No differences could be established between the two groups, and we found the same 5-year survival rates of approximately 26% and 29%, respectively, for the invasive carcinomas.
Carcinoma, Transitional Cell↗
Paget's disease of the anal margin.
A follow-up study of 22 patients with Paget's disease of the anal margin was conducted to determine the prevalence of invasive disease and coexisting visceral carcinomas, cure and survival rates. Seventy-three per cent of the patients suffered from persistent pruritus ani. Seven (32 per cent) patients had malignancy (invasive Paget's disease (n = 5) and coexisting visceral carcinoma (n = 2] and six (27 per cent) developed malignancy (invasive Paget's disease (n = 4) and coexisting visceral carcinoma (n = 2] during follow-up, giving an overall occurrence of malignancies of 59 per cent (95 per cent confidence limits: 36-79). The median follow-up period was 9 (range 0.5-25) years. No difference in length of history could be found between patients with or without malignancy. The estimated cure rate by actuarial analysis among radically treated patients was 64 per cent (95 per cent confidence limits: 43-91) at 1 year and 45 per cent (95 per cent confidence limits: 18-72) at 8 years after primary treatment. The 5- and 10-year crude survival rates of 54 per cent and 45 per cent, respectively, were significantly lower than the corresponding values of 84 per cent and 60 per cent for the normal population (P less than 0.01). Patients with persistent pruritus ani and a perianal skin lesion should be biopsied frequently. If Paget's disease is diagnosed, physical examination of the patient and anorectal region must be done carefully and repeatedly.
Aged↗
Increased urinary excretion of beta-aminoisobutyric acid in a Danish family.
During collection of a control material for determination of urinary excretion of beta-aminoisobutyric acid (beta-AIB), female high excretors were found in four generations in a Danish family. The heredity seemed to be sex related and dominant, unlike previous communications about genetically conditioned high excretors of beta-AIB.
Adolescent↗
Pseudouridine excretion in patients with psoriasis.
The excretion of pseudouridine in the urine of 17 patients with psoriasis was significantly increased. The largest increase was found in patients with psoriatic arthritis. No correlation between the extent of psoriasis and pseudouridine excretion was found. The excretion of pseudouridine was followed in 10 of the 17 patients during treatment with anthralin or PUVA. Pseudouridine excretion decreased significantly during therapy. The possible application of pseudouridine excretion in monitoring the disease activity in psoriasis is discussed.
Adult↗
Malignancy in seborrheic keratoses.
Among 5 500 seborrheic keratoses 3 were found with marked squamous cell atypia. Clinically they were seborrheic keratoses. Even though they were incompletely removed, no recurrences were observed. In contrast to some reports in the literature we regard these lesions as biologically benign, and suggest that they be treated accordingly.
Aged↗
Keratoacanthoma of the anus. Report of three cases.
Three cases of keratoacanthomas localized to the anal region are reported--one in the anal canal and two at the anal margin. The duration of the tumors before treatment was very short (three to nine weeks). Treatment consisted of local excision or curettage and electrocoagulation. No recurrence of the tumors was found at follow-up four to six years after treatment.
Aged↗
[Carcinoma cuniculatum. A rare warty tumor of the skin erroneously diagnosed].
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Adult↗
[Sweet's syndrome. Acute febrile neutrophil dermatosis].
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Female↗
Elbow eruptions in nickel and chromate dermatitis.
In 7 patients with nickel or chromate allergy and dyshidrotic hand eczema, we observed symmetric hyperkeratotic lesions on the elbows which ran a similar course to the hand dermatitis. Histopathological examinations show findings suggestive of lichen simplex chronicus and subacute-chronic dermatitis, but exclude psoriasis. We conclude that these elbow lesions are a characteristic of systemic allergic contact dermatitis.
Adult↗
Correlations of pseudouridine in 8-hour and 24-hour urinary samples determined by high-performance liquid chromatography.
The correlations of Pseudouridine (psi) values in 8 h and 24 h urinary samples from 23 healthy persons were determined. Pseudouridine in the 8 h urinary samples was measured by high-performance liquid chromatography and the 24 h excretion was calculated from the results of three 8 h determinations. Simultaneous determinations of urinary creatinine were performed by Jaffe's reaction. Based on the 8 h values of urinary Pseudouridine the results demonstrated a constant excretion of Pseudouridine in the 24 h periods, if the values were related to the urinary creatinine. The precision in using this ratio as an indicator for normal 24 h excretion of Pseudouridine was 90.5% for males and 92.5% for females.
Adolescent↗