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Biomedical subjects

K Edström

Publications and source records attributed to K Edström.

At least 19 recordsLinked to original sources
PubMed1987

Prevalence of subjectively experienced symptoms in a population sample of women with special reference to women with arterial hypertension.

Women, participants in a population study and representative of middle-aged women in the general population, were asked to complete a questionnaire containing 30 questions about prevalence or absence of 30 specified complaints during the last three months prior to the investigation. As a whole, complaints were common. E.g. more than 30% reported sleep disturbances, 40% general fatigue and 40% depressive symptoms. There were some differences between the different age groups studied with respect to different complaints but the total number of stated complaints were similar in the different ages. A special analysis was made concerning antihypertensive drugs and blood pressure levels. The most obvious finding with respect to these variables was that symptoms were common in women with low blood pressure (below 120 mmHg).

Adult↗
PubMed1986

Psychosocial factors and risk of ischaemic heart disease and death in women: a twelve-year follow-up of participants in the population study of women in Gothenburg, Sweden.

A community sample of 795 women of the ages 38, 46, 50 and 54 yr was subjected to comprehensive medical and psychiatric examinations and was followed up for 12 yr. The 12-yr incidence of angina pectoris was 3.2% and of electrocardiographic changes indicating ischaemic heart disease 5.8%. The corresponding incidence of myocardial infarction was 1.4% and death rate 4.2%. High initial ratings of passive dependency, neuroticism, experience of strain, grade of mental disorder and severity of major or minor depression were predictive of angina pectoris. A low rating of aggression was predictive of the development of electrocardiographic changes indicating ischaemic heart disease. Low ratings of guilt feelings and neurotic self-assertiveness were predictive of myocardial infarction. Death rate was not related to any of the psychosocial factors studied. These associations remained significant after adjustments for age, social class, marital status or confounding conventional risk factors for ischaemic heart disease. The results show that the different clinical manifestations of ischaemic heart disease are related to different sets of psychosocial predictors.

Adult↗
PubMed1979

Techniques of induced abortion, their health implications and service aspects: a review of the literature.

This literature review indicates that menstrual regulation during the fifth to seventh week of pregnancy is not always as free from risk as has sometimes been claimed. In particular, it has a higher failure rate, in terms of continued pregnancy, than has abortion by suction in later stages of pregnancy.Vacuum aspiration is still the method of choice until the beginning of the eleventh week of pregnancy. After that, it seems to be slightly more hazardous than dilatation and curettage (D & C). Preoperative cervical dilatation seems to be beneficial after the tenth week, even though its effectiveness in preventing cervical tears and subsequent cervical incompetence in primigravidae remains to be definitely proven.For second trimester abortions, there is an urgent need for controlled studies, in the thirteenth to fifteenth week, to compare the increasingly popular modified D & C technique with various two-stage techniques, both in terms of safety and of cost-effectiveness. Prostaglandins for second trimester abortions have not quite fulfilled their promise as a relatively risk-free technique; they do, however, decrease the time interval between the administration of the abortifacient and the expulsion of the fetus.Aspects of abortion care other than the purely technical ones are much less well covered by research. For instance, very little is known about the acceptability of various abortion and anaesthetic techniques to either pregnant women or hospital staff. More studies are also needed on the interaction of pregnant women with the service providers at various levels and on how this affects their subsequent reproductive behaviour.

Abortion, Induced↗
PubMed1977

The safety of local anesthesia and outpatient treatment: a controlled study of induced abortion by vacuum aspiration.

The safety of early vacuum aspiration performed as an outpatient procedure using local anesthesia was examined in a controlled study sponsored by the World Health Organization and undertaken in two centers in Yugoslavia and Singapore. The sample consisted of healthy women whose pregnancies were between 7 and 12 weeks in duration. Follow-up four weeks after abortion was nearly 100 percent in both centers. No important differences in complication rates were found between the different types of services and anesthesia, even though overall complication rates differed markedly between centers. Overnight postabortion observation was not associated with any decrease in complications.

Abortion, Induced↗
PubMed1977

Complications following induced abortion by vacuum aspiration: patient characteristics and procedures.

Complications following early induced abortion by vacuum aspiration were examined in a controlled study. Data were collected on healthy women 7--12 weeks pregnant at the time of abortion. No association was found between complication rates and age, marital status, or parity. However, women in their first pregnancies and those who had experienced an induced or spontaneous abortion in their previous pregnancy had a higher rate of complications following the current induced abortion.

Abortion, Induced↗
PubMed1975

Infants of mothers with a high and of mothers with a low insulin response to glucose infusion. Glucose tolerance, insulin response and clinical appearance during the early neonatal period.

Diabetic mothers affect their offspring during pregnancy, sometimes giving rise to the complete symptoms of diabetic fetopathia with the typical appearance of the child high birth weight, hyperinsulinism, etc. Some of these traits have also been reported to appear in the infants some time before the onset of diabetes in the mother, but no prospective study of infants born to truly prediabetic mothers has yet been reported. Thus it is not possible to say whether or not the previously reported effects are related to an undetected, subclinical diabetes in the mother. A prospective study of the insulin reponse to glucose during pregnancy [9] has been previously published, which included 11 women with a low insulin response to glucose infusion (GIT) - a prediabetic type of insulin response according to the definition of Cerasi and Luft [5] - and a control group of 14 women with a high insulin response to glucose infusion. In the following the neonatal findings in these 13 infants of low insulin responders (ILR) aand 14 infants of high responders (IHR) are reported...

Birth Weight↗
PubMed1975

Glucose tolerance in newborn infants of healthy mothers: its relationship to the mothers' insulin response to glucose infusion.

It has earlier been postulated that a low insulin response to a glucose infusion is characteristic for the prediabetic individual (Cerasi & Luft 1967c). There is also evidence that some infants of individuals with low insulin response might have a carbohydrate metabolism that is in some respects similar to that of newborn infants to diabetic mothers (Edström et al. 1974). In the present study 15 infants to low insulin responders (ILR) and 22 infants to high insulin responders (IHR) were subjected to an intravenous glucose load (IVGTT) at 2-24 h age. A significant difference in glucose tolerance was found between the groups, the mean k-value for the ILR being 1.39 plus or minus 0.41 and that for the IHR 1.05 plus or minus 0.09 (P smaller than 0.05). No mothers were found to have a gestational diabetes (with the possible exception of one low insulin responders) but during late pregnancy the mean k-value at IVGTT in the low responders decreased from non-pregnant values (the mean difference being 0.41 plus or minus 0.20, P smaller 0.025) while the high responders did not show a corresponding decrease (mean difference 0.12 plus or minus 0.25, P greater than 0.05). No other differences between the groups of infants that could influence the k-value could be found apart from the mothers being low or high insulin responders. Our findings show that a low insulin response in the mothers might effect the glucose tolerance of the foetus even in the absence of continuous maternal hyperglycaemia in late pregnancy.

Birth Weight↗
PubMed1975

Acid-base and electrolyte balance in infants of diabetic mothers. Vaginal delivery versus caesarean section.

The acid-base and electrolyte balance of 30 women studied at delivery and in their infants during the first 48 h. 18 women were diabetics, 10 of these were delivered vaginally (DMvag) and 8 by elective caesarean section (DMcs). 12 healthy women were vaginally delivered (HMvag). The infants of diabetic mothers (IDM) received active infusion therapy. At birth the DMvag and their infants (IDMvag) had a more pronounced metabolic acidosis than the DMcs and their babies (IDMcs). The largest metabolic acidosis occurred, however, in the group of HMvag and their infants (IHMvag). After birth no significant differences were obtained in the acid-base and electrolyte balance between IDMvag and IDMcs. The plasma potassium level remained lower in IDM than in IHM. The study stress the importance of adequate management of diabetes in pregnancy in combination with active intravenous therapy during delivery and to the infant in the immediate neonatal period. The slightly larger metabolic acidosis seen in combination with vaginal delivery suggests that this mode of delivery should not be attempted uncritically in diabetic women.

Acid-Base Equilibrium↗
PubMed1975

Patterns of free fatty acids, glycerol, D-beta-hydroxybutyrate and insulin in pregnant women and their newborn infants. Effects of a low and a high insulin response to glucose in the mothers.

Twenty-eight healthy women, 17 with high and 11 with low insulin response to glucose but with normal glucose tolerance, were followed throughout pregnancy. Plasma FFA, glycerol and D-beta-hydroxybutyrate as well as plasma insulin and glucose in blood were determined before and during a glucose infusion test (GIT) in each trimester and after pregnancy. In 13 infants of high insulin responders (IHR) and 10 infants of low responders (ILR) an intravenous glucose tolerance test (IVGTT) was performed, and the above lipid parameters were studied at birth and during the IVGTT. The low responder group was postulated to consist mainly of prediabetic individuals (8). Their infants have previously been shown to have an increased glucose assimilation rate at IVGTT (12, 13), as has been shown for infants of diabetic mothers. There was little difference between the two groups of mothers except for the insulin levels during the GIT in non-pregnant and early pregnant subjects, which were considerably lower in the low responders. They all had decreased fasting levels of FFA, glycerol, and D-beta-hydroxybutyrate in mid-pregnancy and normal values in late pregnancy. The ILR showed the same changes in FFA and glycerol as the IHR, but their D-beta-hydroxybutyrate levels were higher at birth than those of the IHR and lower after birth. Another difference found, was the correlation between birth weight and fasting insulin (and to some extent the insulin level at birth) in the ILR group, which was not found in the IHR. Apart from those differences the ILR and the IHR seemed to handle their fat metabolism in a similar way in the early neonatal perinatal period.

Adult↗