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Biomedical subjects

K Eurenius

Publications and source records attributed to K Eurenius.

At least 19 recordsLinked to original sources
PubMed1984

Aldehyde-induced platelet aggregation.

Formaldehyde, acetaldehyde, malondialdehyde, glutaraldehyde and paraldehyde, when added in vitro to platelet-rich plasma, generate a similar distinct platelet aggregation response which is dose dependent when measured with a manual visual microscopic technique and by computerized image analysis, 'computerized platelet aggregation analysis'. Light transmission aggregometry did not measure this aggregation in a reliable manner. The aggregating reaction was specific to the aldehyde group and was not seen when the aldehyde was replaced by an alcohol, ketone, or acetate group in the case of acetaldehyde. The maximal aggregating effect of these aldehydes was directly proportional to the number of aldehyde groups per molecule. Aggregation was found to require the presence of plasma, but not von Willebrand's factor.

Acetaldehyde↗
PubMed1979

Multilevel care. A Veterans Administration initiative in health care cost control.

The Veterans Administration's (VA) Department of Medicine and Surgery, the largest of the civilian federal health care systems, is under continuous White House, congressional, and public pressure to provide greater accountability and increased cost-effectiveness for its $5 billion-plus annual budget. Responding to these pressures, the VA is evaluating in ten of its 172 medical centers a new system of resource allocation and financial management known as a multilevel care system. This is a major VA intiative with highly important implications for both the VA and the private health care sector.

Cost-Benefit Analysis↗
PubMed1977

Myelopoiesis in the infected burn.

A modified bone marrow clonal cell culture technique was used to study granulocyte production during burn injury and sepsis. When rats were inflicted with a 30 percent third-degree scald burn, marrow cellularity and colony-forming units in culture (CFU-C) per 10(5) marrow cells increased progressively to four times normal by 7 days after injury. Conversely, When animals were burned and the burn wound immediately seeded with 10(8) Pseudomonas organisms, CFU-C declined steadily until the day of death and reflected a progressive loss in marrow cellularity. Further studies were conducted replacing or mixing standard colony-stimulating serum with burn, burn-infected, or normal rat serum. The results indicated that colony-stimulating activity could be supplied by postburn serum, but not with normal or burn-infected rat serum. Additionally, serum from burned-infected animals significantly inhibited colony formation when added to the standard colony-stimulating serum. Marrow failure appears to be the major cause for granulocytopenia in burn infection and may partly be serum mediated.

Animals↗
PubMed1977

The effects of dopamine on human platelet aggregation, in vitro.

An unexpected inhibition of human platelet aggregation by dopamine -- the precursor of epinephrine and norepinephrine -- is presented. Human platelet-rich plasma was incubated in an aggregometer for 120 seconds at 37 degrees C, with either dopamine or saline control. Adenosine diphosphate, epinephrine or collagen was added as the aggregating agent. Dopamine inhibits induction of platelet aggregation by all three agents and causes platelet disaggregation. At low doses (400 mug/ml or less), dopamine induces platelet aggregation and enhances ADP-induced aggregation. In addition, a concentration of dopamine of 40 mug/ml induces aggregation, enhances ADP-induced aggregation and inhibits epinephrine aggregation. Phentolamine is able to block dopamine enhancement of ADP aggregation, but propranolol and haloperidol fail to prevent dopamine inhibition of epinephrine aggregation. These observations are explained neither by the currently known intracellular actions of dopamine which involve competition with serotonin nor by a single mediator such as cyclic adenosine 3':5'-monophosphate. It appears that dopamine may exert its effects via the platelet membrane.

Adenosine Diphosphate↗
PubMed1976

Minimal heparin cofactor activity in disseminated intravascular coagulation and cirrhosis.

An assay technic for measuring heparin cofactor activity in which antithrombin activity can be assessed without plasma attenuation even in the presence of therapeutic levels of heparin is presented. Heparin-activated anti-thrombin activity was markedly depressed in plasmas of four patients with disseminated intravascular coagulation and in ten patients with cirrhosis. Residual activity in those plasmas appeared qualitatively normal, and no inhibitor (platelet factor IV activity) was observed. Plasmas from patients with disseminated intravascular coagulation and cirrhosis required more heparin to obtain in vitro clotting time prolongation equivalent to normal.

Alpha-Globulins↗
PubMed1976

Correlation between pseudomonas burn wound infection and granulocyte antibacterial activity.

The relationship of granulocyte bactericidal activity with three strains of pseudomonas and the virulence of these same organisms in a scald-burned rat model was investigated. Resistance to bactericidal activity was measured for each strain, using an in vitro assay and normal rat peritoneal granulocytes. Mortality was recorded for rats receiving a 30% third-degree scald burn with simultaneous pseudomonas burn wound infection. A positive correlation between mortality and resistance to bactericidal activity of granulocytes was obtained. These studies stress the importance of pseydomonas strain specificity in burn wound infection and indicate that mortality from these strains may be specifically related to their resistance to the bactericidal activity of leukocytes.

Animals↗
PubMed1976

Granulocyte function and Pseudomonas burn wound infection.

Granulocyte function in burn injury has been evaluated with an in vitro animal assay. Bactericidal activity, using this technique, was markedly depressed only when granulocytes from scald burned rats were challenged with each of three strains of Pseudomonas aeruginosa in the presence of autologous postburn serum or heat-inactivated serum. Preincubation of postburn and normal serum at 37 degrees C for 1 h resulted in normal phagocytosis. These studies validate an investigation of plasma and/or granulocyte replacement therapy in the burned patient.

Animals↗
PubMed1976

Unusual cytoplasmic inclusions in blast cells in acute leukemia.

A 36-year-old man manifested the clinical signs of acute leukemia. Blast cells in the blood and bone marrow contained many large cytoplasmic inclusions. Cytochemical and ultrastructural studies indicated that the leukemic cells were of lymphocytic origin. Three kinds of inclusions were identified on electron microscopy: one type of inclusion contained virus-like particles; another resembled those in cases with hairy cell leukemia; and the third appeared to be autophagic in nature. The presence of the second type of inclusion in the blast cells and the relative chronicity of the clinical course suggest that this patient's disease is of lymphocytic origin, similar to hairy cell leukemia.

Adult↗