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Biomedical subjects

K F Akl

Publications and source records attributed to K F Akl.

8 recordsLinked to original sources
PubMed1992

Childhood chronic renal failure in Qatar.

Thirty children below the age of 12 with chronic renal failure (CRF) were studied. In 21 patients (70%) the renal failure was secondary to congenital or familial aetiology. Obstructive uropathy (53.3%), mostly due to posterior urethral valves (40%), comprised the majority of cases. Four cases (13.3%) were secondary to reflux nephropathy. It is concluded that the majority of cases of CRF in the state of Qatar are secondary to potentially treatable or preventable conditions. Use of antenatal ultrasonography combined with aggressive management of obstruction and urine infection may help reduce morbidity and mortality.

Child↗
PubMed1990

Henoch-Schöenlein syndrome in Qatar: the effects of steroid therapy and paucity of renal involvement.

This is a retrospective study of 40 patients admitted to Hamad General Hospital in the state of Qatar between January 1983 and December 1987 with the diagnosis of Henoch-Schöenlein syndrome. Of the 40 patients, 25 were boys and 15 were girls, with a ratio of 1.6:1. Ages ranged from 2 years 3 months to 13 years, with a mean of 6 years. There were six episodes of recurrence in four patients. There was a clustering of cases in late summer and early winter. About half of the patients had a history of preceding upper respiratory infection. All of them had the typical skin rash. The percentages of joint, gastro-intestinal and renal manifestations were 80%, 65% and 17.39%, respectively. One patient had penile swelling which has not been reported before. Steroid therapy seemed to enhance early resolution of abdominal pain but did not affect the course of the syndrome. Sixty-seven per cent of the patients were followed up for from 4 weeks to 5 years, with a mean of 8 months. Only one patient with renal involvement continued to have proteinuria with microscopic haematuria and hypertension. The rest were normal within about 2 months. The remarkably low incidence of renal involvement in our study may be related to local variations in causative factors. Henoch-Schöenlein syndrome is a milder disease in Qatar than in other countries.

Adolescent↗
PubMed1989

Primary nephrotic syndrome in Qatar (Arabian Gulf).

Sixty-two children with primary nephrotic syndrome were studied. The mean age at diagnosis was 5.5 years (range 1.5-11 years). Fifty-five were initially steroid sensitive (88.7 per cent) and seven (11.2 per cent) were steroid resistant. Renal biopsies performed on six of the steroid-resistant cases showed focal glomerulosclerosis in three, minimal change disease in two and membranoproliferative glomerulonephritis in one. Of the 55 children who were initially steroid responsive, 12 (21.8 per cent) had a frequently relapsing course, while three (5.5 per cent) became steroid resistant. Two out of the 12 who had frequent relapses became steroid resistant and one became steroid dependent. Renal biopsies performed on six of these patients showed minimal change disease in five and segmental glomerulosclerosis in one. Renal biopsies of two out of three patients who were initially steroid responsive but who later became resistant showed minimal change disease in one and segmental sclerosis in one.

Biopsy↗
PubMed1977

Cephradine penetration into cerebrospinal fluid and effects of its administration into the cerebral ventricles of cats.

In cats that had high, sustained serum concentrations of cephradine, penetration of the drug into the cerebrospinal fluid (CSF) was poor. Serum cephradine levels were, on the average, 100-fold higher than the CSF levels. On the other hand, the direct injection of cephradine into the lateral cerebral ventricles of cats yielded high CSF cephradine concentrations without evidence of central nervous system toxicity.

Animals↗
PubMed1976

Skin lesions, angioedema, eosinophilia, and hypocomplementemia.

A six-year-old girl with recurrent urticaria and angioedema, vasculitis, and probable renal disease exhibited marked blood eosinophilia, increased levels of serum IgE, circulating Clq precipitins, and hypocomplementemia with evidence of activation of complement by the classic pathway. Biopsies of skin and muscle revealed heavy infiltrations of the vessel walls with eosinophils. Immunofluorescence studies revealed deposition of IgM, IgE, and C3 in the vessel walls. Exacerbations of the disease were associated with an increase in the eosinophil count and a decrease in the serum levels of C4 and C3. Remission was achieved with corticosteroid therapy. This patient has many features in common with the syndrome of skin lesions, angioedema, and hypocomplementemia recently described in adults.

Child↗