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Biomedical subjects

K F Cheong

Publications and source records attributed to K F Cheong.

26 records · Page 2Linked to original sources
PubMed1998

Postanaesthetic shivering--a comparison of thiopentone and propofol.

One hundred and sixty patients undergoing minor surgical procedures were randomly allocated to receive either thiopentone or propofol for induction of anaesthesia. All patients were assessed in the recovery period for the development of postanaesthetic shivering. Twenty patients (25%) in the thiopentone group and 8 patients (10%) in the propofol group developed postanaesthetic shivering (p < 0.05). There was no statistically significant difference in tympanic temperature between shivering and nonshivering patients. Propofol as an induction agent is associated with a lower incidence of postanaesthetic shivering as compared to thiopentone.

Adult↗
PubMed1997

Oxygen consumption--a comparison between calculation by Fick's principle and measurement by indirect calorimetry.

Oxygen consumption values calculated by Fick's principle (cVO2) were compared to simultaneously obtained values measured by indirect calorimetry (mVO2) in two groups of patients; post-coronary artery bypass graft (post-CABG) and septic shock. In both groups of patients, oxygen consumption values derived using indirect calorimetry were higher than that from Fick's principle. Whilst the bias obtained between the two methods of measurement were of acceptable amount clinically, the limits of agreement were wide: -57 to 51 ml.min-1.m-2 in the post-CABG group and -101 to 67 ml.min-1.m-2 in the group of septic patients; indicating that significant differences exist between paired individual values such that cVO2 and mVO2 were not interchangeable in this study.

Adult↗
PubMed1997

Monoplegia following obstetric epidural anaesthesia.

We describe a case of transitory monoplegia following obstetric epidural anaesthesia which we believe to be either due to direct trauma to the nerve roots or radicular artery spasm resulting in spinal cord ischaemia both secondary to the epidural catheter. An obstetric epidural was performed on a 34-year-old lady with no significant past medical history. Transient radicular pain down her left leg was experienced during the insertion of the catheter. She had unilateral block on her left side which could not be rectified despite injecting local anaesthetics in the right lateral position, resiting the epidural catheter, and administering a total dose of 6 ml of 1.5% plain lignocaine and 19 ml of 0.25% plain bupivacaine. There was no hypotension, and no vasoconstrictor was used epidurally. She still had left-sided numbness and weakness 9 hours after removal of the catheter, but without urinary or bowel dysfunction. A magnetic resonance imaging scan excluded any space occupying lesion. She was managed conservatively and had complete recovery 35 hours after the last dose of local anaesthetics.

Adult↗
PubMed1997

Variants of chromosome 9 in phenotypically normal individuals.

The human chromosome 9 displays the highest degree of structural variability. Four different types of variants are described including pericentric inversion, extra G-positive band in the q arm, additional G-positive band in the p arm and duplication of band 9q21-q22. It is important to demonstrate inheritance from a phenotypically normal individual in order to differentiate between a variant chromosome and an abnormal chromosome.

Azure Stains↗
PubMed1996

The 14.6 kd rubber elongation factor (Hev b 1) and 24 kd (Hev b 3) rubber particle proteins are recognized by IgE from patients with spina bifida and latex allergy.

Two major water-insoluble proteins are located on the surface of rubber particles in Hevea brasiliensis latex. A 14.6 kd protein (Hev b 1), found mainly on large rubber particles (> 350 mm in diameter), and a 24 kd protein (Hev b 3), found mainly on small rubber particles (average diameter, 70 nm), are recognized by IgE from patients with spina bifida and latex allergy. Although Hev b 1 (also called the rubber elongation factor [REF]) has previously been reported as a major latex allergen, this conclusion has been disputed on the basis of results from other studies. The allergenicity of Hev b 1 is verified in this study by testing the recombinant protein generated from its gene. Because allergenicity is confined to patients with spina bifida and not observed in adults sensitive to latex, it is not a major latex allergen. The identification of Hev b 3 as another allergen originating from rubber particles is confirmed by immunogold labeling and electron microscopy. Observations with the monoclonal antibody USM/RC2 developed against Hev b 3 show that the protein has a tendency to fragment into several polypeptides of lower molecular weight (from 24 kd to about 5 kd) when stored at -20 degrees C. There is also indication of protein aggregation from the appearance of proteins with molecular weights greater than 24 kd. Fragmentation of Hev b 3 is induced immediately on he addition of latex B-serum, which is normally compartmentalized in the lutoids in fresh latex. In the preparation of ammoniated latex (used for the manufacture of latex products), the lutoids are ruptured, and the released B-serum reacts with Hev b 3 on the rubber particles to give rise to an array of low molecular weight polypeptides that are allergenic to patients with spina bifida.

Adult↗
PubMed1996

Asystole following laryngoscopy and endotracheal intubation: a case report.

Severe bradycardia and asystole are very rare complications following laryngoscopy and endotracheal intubation. In this report, we describe a case in which these life-threatening complications occurred in a healthy male during induction of general anaesthesia. Activation of vagal reflexes during manipulation of the airway and the use of vagotonic drugs at induction are the mechanisms postulated to be responsible for these phenomena. Analysis of heart rate variability measurements may be useful in identifying patients at risk for development of these haemodynamic alterations during the induction of anaesthesia so that appropriate drugs and monitoring can be administered.

Adult↗
PubMed1995

Propofol and postanaesthetic shivering.

Sixty ASA grade 1 unpremedicated patients scheduled for minor elective surgery were randomly allocated to receive general anaesthesia consisting of either propofol-nitrous oxide in oxygen or a conventional technique of thiopentone-isoflurane-nitrous oxide-oxygen. Baseline axillary temperature readings, duration of operation and intra-operative decrease in axillary temperature were similar in both groups. The patients who received propofol-nitrous oxide-oxygen anaesthesia had a significantly lower incidence of postanaesthetic shivering than the control group. A propofol-nitrous oxide-oxygen technique may be preferable when postanaesthetic shivering is deemed undesirable.

Adolescent↗