Biomedical subjects
Publications and source records attributed to K F Knowles.
We describe a case of severe tuberculous pancreatitis in a 26-year-old woman with miliary tuberculosis. Recognition of this complication is important as it may interfere with adequate absorption of anti-tuberculous drugs and it can lead to unnecessary laparotomy.
Streptococcus pneumoniae was present, in pure or mixed culture, in 43 (0.08%) of 53,499 urine cultures submitted from a pediatric population over a 4-year period. Data were analyzed from 28 children, from whom 78% of these positive cultures originated. Ninety-six percent of the children were female, and the median age was 3 years (range, 0.4 to 17 years). Only five children had S. pneumoniae as the sole organism cultured from the urine, and all five had only a single urine culture. Urine from the other 23 children contained other organisms as well. Small numbers of pneumococci were found in most urines: 74% contained less than 10(4) CFU/ml and 93% contained less than 10(5) CFU/ml. There was no association between genitourinary symptoms and pneumococcosuria, and complete resolution of symptoms occurred in both treated and untreated children. Pneumococcosuria could not be explained by pneumococcal bacteremia. We conclude that pediatric pneumococcosuria is not associated with urinary tract infections in children, or with pneumococcal bacteremia or invasive disease elsewhere. Pneumococcosuria probably reflects contamination of urine specimens with S. pneumoniae from perineal colonization.
Eight cases of neurocysticercosis were encountered at the two major neurological centers affiliated with McGill University in Montreal in 4 years. All patients were immigrants who had been in Canada for a period of 1 to 18 years and came from South America (three cases), Haiti (three cases), and Greece (two cases). Five patients had parenchymal cysts and presented with epilepsy; three had the racemose form and presented with hydrocephalus. Four patients with parenchymal cysts were treated by removal of the cysticercus and did well. One patient with numerous cysts was treated with praziquantel with good clinical and radiological results. Two patients with the racemose form were treated by cyst aspiration, cerebrospinal fluid (CSF) diversion, and praziquantel and did well. Another patient with the racemose form, seen before the advent of praziquantel, died of cysticercosis infection. Neurocysticercosis is not uncommon in the immigrant population of large North American cities. Single symptomatic cysts can be evacuated surgically with good results; multiple parenchymatous cysts can be treated with praziquantel. Patients with the racemose form who are treated with CSF diversion and praziquantel do well, although those who are only treated surgically die of their disease.