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Biomedical subjects

K F Manthey

Publications and source records attributed to K F Manthey.

At least 19 recordsLinked to original sources
PubMed1989

[Heliotherapy in iridocyclitis and intermediate uveitis].

In a pilot in 1985 we treated 45 patients suffering from recurrent anterior uveitis with heliotherapy (Dead Sea, Israel), improvements were noticed in 40% of the probants during the following year. In a further clinical trial 14 patients (25 affected eyes) received treatment with heliotherapy twice for 3 weeks with a 12 months interval. The clinical findings showed a significant correlation between administration of the therapy and intermittent inflammation of the eyes.

Adolescent↗
PubMed1988

[Modification of the course of chronic intraocular inflammations by sunlight (Israel study)].

Natural treatment methods are currently becoming more and more interesting, in part due to recent results of experimental and clinical research. It has been shown that light of certain wavelengths has a systemic immunosuppressive effect. It therefore seemed logical to expose patients suffering from chronic iridocyclitis or intermediate (peripheral) uveitis to high doses of solar radiation. Following a stay in Israel (Dead Sea), a transient increase in visual acuity was observed. Inflammatory activity and the number of inflammatory attacks decreased. This could be the first step toward a more "physiological" method of immunosuppression in the treatment of chronic uveitis.

Adolescent↗
PubMed1984

[Climatotherapy in chronic inflammations of the uvea].

Treatment of uveitis depends on the inhibition of the inflammatory reaction by corticosteroids or immunosuppressive agents. "Climatotherapy" remains a controversial subject and is generally not accepted. To test its efficacy a pilot study was undertaken. Children with chronic iridocyclitis or intermediate uveitis were sent to Israel for 3 weeks. During the follow-up period of 26 months there was an initial regression of the inflammatory reaction in most cases, followed by varied courses depending on the severity of the disease. Although no definite conclusions can be drawn owing to the small number of patients (5) there might been a beneficial effect. It seems very difficult to prove the efficacy of such "treatment", since not only the climate but also many other environmental factors were changed.

Adolescent↗
PubMed1983

[Enzyme-linked-immunosorbent assay (ELISA) for demonstrating antibodies against toxoplasmosis].

Serologic tests for specific antibodies are the primary method of diagnosis in suspected cases of toxoplasmosis. Available tests differ widely with regard to specificity and sensitivity. The enzyme-linked immunosorbent assay (ELISA) is specific for toxoplasmosis and has a sensitivity comparable to radio-immuno assays. The reproducibility of the CORDIA-T assay, tested by the authors in their laboratory, was excellent; the test itself was very easy to perform. When testing sera of 590 apparently normal subjects the authors found specific antibodies in 17.9% to 48.1% of all cases, depending on age. The ELISA-test seems to be useful in the diagnosis of ocular toxoplasmosis.

Adolescent↗
PubMed1982

Bilateral acute retinal necrosis.

Four patients who experienced the sudden onset of anterior uveitis with large keratic precipitates and dense vitreous opacities developed confluent yellow-white swellings and exudates in the peripheral retina and sheathing and obliteration of retinal arteries. After absorption of the exudates, atrophic patches in the peripheral retina and a funnel-shaped retinal detachment with many tears appeared. Angiograms showed retinal edema, fluorescein leakage from the choroid in the affected areas, and perivasculitis of the retinal arteries. Although treatment seemed unable to alter the course of the disease, in one case the retina reattachment after vitrectomy and filling of the vitreous space with silicone oil. Histopathologic studies disclosed extensive atrophy and degeneration of the outer retinal layers and pigment epithelium and occlusion of the retinal vessels. An infection may trigger the uveitis, leading to an autoimmune sensitization against rods and cones that causes severe local immune-complex disease and retinal vasculitis.

Adult↗
PubMed1982

[Endophthalmitis caused by mycobacterium tuberculosis].

A 60-year-old woman developed an anterior uveitis of unknown etiology in her right eye. Topical treatment was corticosteroids led to a regression of the inflammation, but three months later a severe relapse occurred, followed by endophthalmitis and blindness. At this time a previously unknown pulmonary tuberculosis was diagnosed. In histologic sections of the enucleated eye numerous acid-fast bacilli were demonstrated. Diagnostic and therapeutic considerations are discussed.

Adrenal Cortex Hormones↗
PubMed1980

[Incidence of immune reactions following penetrating keratoplasty (report on 100 consecutive interventions) (author's transl)].

The outcome of 100 consecutive penetrating keratoplasties was investigated. At present, inadequate surgical technique does not appear to be the major cause of graft failure; instead, immunologic reactions are largely responsible for graft failure. Taking corneal disease and the degree of vascularization as criteria, the prognosis was judged to be favourable in 38 of the 100 keratoplasties, less favorable in 56, and poor in six. In the first group, graft failure occurred only five times (about 13%), whereas in the second group graft reactions of variable degrees were found in about 64%. As expected, the group with a poor prognosis showed the poorest results. Postoperative follow-up over a long period of time and adequate local steroid therapy are necessary.

Adolescent↗