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K F Selivanova

Publications and source records attributed to K F Selivanova.

22 records · Page 2Linked to original sources
PubMedDate not supplied

[Transient minor fractions of human serum albumin: physico-chemical properties].

From 7 to 8 minor fractions were isolated from normal and pathologically altered human blood serum albumin by means of isoelectric focusing in borate-polyol system. As distinct from the whole albumin molecule, these minor fractions contained 12-14% carbohydrates, I-1.2% of which were linked by covalent bonds while the rest of it were absorbed. The fractions included a number of amides, amount of which was gradually elevated with an increase in the isoelectric point. As shown by circular dichroism studies content of alpha-spirals decreased from 20% to 5% in the proteins, depending on the pI value. Spontaneous deamidation was noted during storage. Normally the content of these proteins constituted from 3% to 4%; in liver cirrhosis it might increase up to 50%.

Carbohydrates↗
PubMedDate not supplied

[Isoelectric spectra of blood serum albumin in patients with disturbed thyroid gland function and nephrotic syndrome].

In patients suffering from diffuse toxic goiter, hypothyrosis and nephrotic syndrome changes in dynamics of treatment are found in the albumin molecule by means of the isoelectric focusing in the borate-polyol system and spectropolarimetry. The changes consist in an increased content of the albumin fractions in the range of pH 4.3-4.5 and 5.5-5.7. In patients suffering from toxic goiter conservative therapy rises the content of the fractions in the range of pH 4.3-4.5, whereas under hypothyrosis and nephrotic syndrome the content of the fraction decreases in the range of pH 5.5-5.7. Parallel studies of the dispersion of albumin optic rotation support despiralization of its molecule under all the dispersion of albumin optic rotation support despiralization of its molecule under all types of the pathology. The results obtained may be of diagnostic and prognostic significance.

Goiter↗