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Biomedical subjects

K Fasshauer

Publications and source records attributed to K Fasshauer.

13 recordsLinked to original sources
PubMed1978

[Lesions of the peripheral nerves in Wilson's disease. Electrodiagnostic findings (author's transl)].

Electrodiagnostical studies were carried out on three patients with Wilson's disease. The motor nerve conduction velocity was low but not markedly decreased. Some values of the sensory conduction velocity were decreased; the sensory action potentials showed low amplitudes and contained large amounts of late phases. Also, the electromyogram of one female patient showed denervation in the begin of treatment. There are no indications of polyneuropathy in Wilson's disease in the literature. There have been histological reports, however, which indicated lesions of the peripheral nerves in Wilson's disease as our own electrodiagnostical findings do.

Adult↗
PubMed1977

[Electromyographic studies on the effect of the cinnamamide derivative LCB-29 in spastic syndromes (author's transl)].

In ten patients with para- or tetraspastic syndromes of various etiology 5 different spastic phenomena demonstrating pathologically raised excitability of muscle regulation functions were registered electromyographically before and 1 h after i.v. administration of N-(hydroxy-2-ethyl)-cinnamamide (LCB-29). In the majority of cases a marked decrease of spasticity was registered. The rapid onset of this effect of LCB-29 allowed constant test conditions and therefore eliminated other influences on spasticity. The decrease of raised polysynaptic excitability at spinal level led, at least in part, to the assumption of a spinal site of action of LCB-29. The absence of a sedative effect with oral medication makes a strong central effect seem less probable.

Adult↗
PubMed1977

[Idiopathic and sclerodermic facial hemiatrophy with generalized myopathy. Clinical, electromyographic and histologic examinations of six patients].

Six patients with facial hemiatrophy (H.f) were thoroughly examined by clinical and laboratory investigations. Two were found to have idiopathic and four facial hemiatrophy due to different types of localized scleroderma. In all cases a generalized myopathy was present, demonstrated by electromyographical, histological, and biochemical means. In none of these cases a hereditary or neurological cause for the facial hemiatrophy was found. However, in two cases autoantibodies against nuclei and muscle were repeatedly obtained. No prolongation of sensory or pain chronaxy occurred in either the patients with sclerodermal or idiopathic facial hemiatrophy. These observations suggest that facial hemiatrophy can originate (a) in a localized scleroderma in the involved part of the face, (b) in an ipsilateral "sclérodermie en coup de sabre", or (c) in the coexistence of both. There is a close pathological and physiological correlation between idiopathic and sclerodermal facial hemiatrophy. In both forms of facial hemiatrophy the disease involves skeletal muscle tissue systematically. This myopathy is similar to that of progressive scleroderma, far exceeding the limited muscular involvement of localized scleroderma. Sclerodermal facial hemiatrophy can be associated with autoimmune phenomena.

Adipose Tissue↗
PubMed1976

[Brachial plexus injuries caused by motor-cycle accidents- catamneses (author's transl)].

During the last eight years we examined 45 patients, mostly juvenile, with brachial plexus injuries arising from motor-cycle and moped accidents. The neurological findings, radiological picture on the myelogramme, sanguineous fluid, different electrodiagnostic examinations and sweat secretion tests provided information on the location of the lesion and the defects to be expected at a later date. However, no method permitted determination of the total extent of the damage. In some cases we observed partial, oftern considerable improvement even in the second and third post-accidential years. Follow-up studies showed the significance of the personality structure as well as social conditions with respect to vocational rehabilitation, and the danger of early resignation. Consequently, rehabilitation efforts should start immediately after the healing of the initially incurred injuries.

Accidents, Traffic↗