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Biomedical subjects

K Fischerman

Publications and source records attributed to K Fischerman.

At least 19 recordsLinked to original sources
PubMed1990

Palliation of oesophagogastric neoplasms with Nd:YAG laser treatment.

The palliative effect of endoscopic Nd:YAG laser treatment of malignant strictures of the oesophagus and cardia was prospectively evaluated in 30 patients. Most (n = 28) were primarily treated for dysphagia, and swallowing was improved in 21 and normalized in 14 of these patients. Two patients were successfully treated for bleeding. Six patients developed complications (including two perforations), and four of these were fatal. The median survival was 4 months (range, 17 days to 14 months). It is concluded that in a great number of patients with inoperable cancer of the oesophagus and cardia, laser treatment is better than other palliative procedures.

Aged↗
PubMed1989

[Cimetidine treatment of stomach cancer].

The effect of cimetidine treatment in cancer of the stomach was investigated in a double-blind, multicentre study comprising eight departments in Greater Copenhagen. Immediately after operation (or the decision not to operate) 181 patients were subdivided at random to treatment with a placebo or cimetidine in a dosage of 400 mg twice daily for two years or until death. Compliance control was carried out every third month. The mean survival in the cimetidine group (450 days, 1-1,826) was significantly longer (p = 0.02) than in the placebo group (316 days, 1-1,653).

Adult↗
PubMed1989

[Nd:YAG laser treatment of cancer of the esophagus and cardia].

In 1988, Nd:YAG laser treatment was employed as palliative therapy for 23 patients with cancer of the oesophagus and cardia. After treatment, half of the patients could ingest light or normal diets and the ability to swallow improved in a total of 3/4 of the patients. Perforation of the oesophagus occurred in two patients and aspiration in two other patients. It is concluded that, in a great number of patients with inoperable cancer of the oesophagus and cardia, laser treatment is better than other palliative therapeutic measures. The indications are discussed.

Adult↗
PubMed1988

Effect of cimetidine on survival after gastric cancer.

The effect of cimetidine on survival was investigated in 181 patients with gastric cancer. Immediately after operation or the decision not to operate, the patients were randomised in double-blind fashion to placebo or cimetidine 400 mg twice daily for two years or until death, with review every three months. Median survival in the cimetidine group was 450 days (range 1-1826) and in the placebo group 316 days (1-1653). The relative survival rates (cimetidine/placebo) were 45%/28% at 1 year, 22%/13% at 2 years, 13%/7% at 3 years, 9%/3% at 4 years, and 2%/0% at 5 years. Survival in the cimetidine group was significantly longer than in the placebo group.

Actuarial Analysis↗
PubMed1987

Combined modality therapy for oesophageal squamous cell carcinoma.

In a prospective study 110 patients with histologically confirmed oesophageal squamous cell carcinoma received radiation therapy combined with bleomycin or a retinoid. Surgery was initially intended in 34 patients and was later on undertaken in 25 of them after irradiation; in 12 patients the operation was regarded as radical and in 4 of these no remaining tumour was found at operation. The survival rate was significantly higher in the operated than in the non-operated patients which entirely depended on the radically operated ones. Survivals up to more than 71 months were observed and the best results were apparently obtained in patients who became tumour-free after preoperative therapy. It is concluded, that the combined treatment was curative only in a few cases and that future studies should be focused on more intensive preoperative treatment and more critical selection of patients for surgery.

Adult↗
PubMed1984

Danish Breast Cancer Cooperative Group (DBCG). Present status and experience.

A brief presentation is given of the Danish national program for standardized therapy of primary breast cancer within the framework of prospective randomized trials. Adjuvant systemic therapy given to high-risk patients has in preliminary studies reduced the recurrence rate in large subsets of patients and the preliminary results also indicate the possibility of improved selection of patients for different treatment modalities. It is also concluded that such a nation-wide study, although it requires extensive administrative effort, implies a number of positive effects, clinical, scientific and educational.

Breast Neoplasms↗
PubMed1982

Effects and side-effects of partial ileal by-pass surgery for familial hypercholesterolaemia.

Ten patients with familial hypercholesterolaemia were subjected to partial ileal by-pass surgery. Plasma cholesterol fell by 41 and 38% and low-density lipoprotein cholesterol by 51 and 46% after six and 18 months respectively. High-density and very low-density lipoprotein cholesterol and plasma triglycerides were unaffected. Alanine aminotransferase increased transiently in half of the patients. Diarrhoea and slight steatorrhoea troubled most of the patients for the duration of 18 months' period of observation. Other long-term side effects were slight but significant increase in the renal excretion of oxalic acid and reduction in the intestinal absorption of calcium. The study shows that this operation has metabolic side-effects that warrant continued medical care of these patients.

Adult↗
PubMed1979

Survival rate in Crohn's disease and ulcerative colitis.

The survival rate in 709 patients with chronic inflammatory bowel disease (CIBD) was calculated by the log rank test. There were 297 patients with Crohn's disease (CD) and 412 patients with ulcerative colitis (UC). In both diseases there was a survival rate of about 94% in the first year of observation against an expected rate of 99.5% in a general population matched for sex and age. This was because a large number of patients were severely ill at their first admission and required immediate or early surgery. During the subsequent 11 years the death rate in CIBD was higher (two to three times) than in the general population. After 12 years the survival rate was about 77% in both CD and UC. The difference was statistically insignificant. There was no significant difference in the sex ratio. The cancer rate was low. No gastrointestinal cancer occurred among patients with CD. Colorectal cancer was found in four patients with UC, three of whom presented with cancer on their first admission. It is concluded that recurrence and reoperation for recurrence in Crohn's disease have not impaired the prognosis compared to ulcerative colitis in this series.

Adolescent↗
PubMed1979

Clinical diagnosis of metastatic carcinoid tumours.

Eighteen patients with metastatic carcinoid tumours were admitted to surgical gastroenterological department of Rigshospitalet during the period 1974--1978. Thirteen had primary carcinoid tumours in the terminal ileum, two in the lungs, one in the pancreas, one in the testis, and one possibly in the retroperitoneum. All patients had distant metastases, 13 in the liver. Carcinoid syndrome with flusing and diarrhoea was present in 15 patients (83%). The time elapsing from onset of symptoms until diagnosis was on an average 2 1/2 years. The most valuable screening test for carcinoid syndrome was determination of the excretion of 5-hydroxy-indol- acetic-acid. The most sensitive investigation for determination of primary tumour and/or metastases was abdominal angiography, which was positive in all cases. Other radiological investigations were less sensitive.

Adult↗
PubMed1976

Survival among patients with liver metastases from cancer of the colon and rectum.

Factors influencing spontaneous survival in 49 patients with liver metastases after cancer in colon/rectum were evaluated. In addition the same evaluation was performed in 12 patients treated with 5-Fluoro-uracil systemically of intraarterially in the hepatic artery. Alkaline phosphatases, elevated more than 4 times normal values, elevated serum alanine aminotransferase, or jaundice are all unfavorable prognostic signs in the spontaneous group. In the 5-Fluoro-uracil treated group only elevated serum dilirubin had the same unfavorable prognostic sign. Even though it seems to be an increased survival time in the 5-Fluoro-uracil treated group it is concluded that metastases to the liver from cancer in colon/rectum assume to be more or less resistent to 5-Fluoro-uracil.

Adolescent↗
PubMed1976

Carcinoembryonic antigen (CEA). A prospective clinical trail in patients with gastrointestinal cancer.

Tests for circulating carcinoembryonic antigen, CEA, in plasma were performed in 29 patients with colonic and rectal cancer, 37 patients with stomach cancer, and in 100 blood donors. Using 5.0 ng per ml as cut off, 48 per cent of the patients with colonic and rectal cancer and 32 per cent of the patients with stomach cancer had elevated CEA-values. The CEA-values could be correlated to the classification of tumours according to Dukes, with significantly elevated values in groups Dukes C and D. The test could reveal 39 per cent of the cases with operable colonic and rectal cancer and 26 per cent of the operable cases of stomach cancer. Five patients with colonic and rectal cancer, and 0 patients with stomach cancer fulfilled the requirements for monitoring. After periods of observation of up to 14 months, definite connection between CEA-values and clinical course could be demonstrated in 1/26 patients submitted to macroscopically radical operation. In 2/7 patients with stomach cancer the CEA-values were entirely misleading. It is concluded that the CEA-test in its present form cannot be recommended for routine employment in patients with gastrointestinal cancer.

Adult↗
PubMed1976

Gatric carcinoma. A prospective study of tumour differentiation correlated to surgical procedures and survival rate.

A prospective study of 100 consecutive patients operated for gastric carcinoma is presented. The resectability was 43 per cent. Primary mortality for palliaktive resections including total gastrectomy was 3.8 per cent with a 2-year survival rate of 20 per cent. The primary mortality and the 2-year survival after palliative surgical procedures including total gastrectomy justify these procedures. Based on histological qualities of the tumourcells a Differentiation Coefficient is defined. In these patients the coefficient could not be compared to the survival rate.

Adult↗