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Biomedical subjects

K Flick

Publications and source records attributed to K Flick.

11 recordsLinked to original sources
PubMed1978

[Studies on chemical structure and analgetic activity of phenyl substituted aminomethylcyclohexanoles (author's transl)].

Phenyl substituted aminomethylcycloalkanole derivatives were synthetized and tested for analgetic activity. Substances with a high ratio between acute toxicity and analgetic efficacy were selected for further investigations. Structure-activity relationships of this group were evaluated and compared with those of morphine and morphine-like 4-phenylpiperidino derivatives. The basic structural requirement for the new compounds is a cycloalkane ring with a phenyl group and a dimethylaminomethyl residue in ortho-position. The analgetic activity is improved if the aromatic ring is substituted with an oxygen containing group in meta-position. In contrast to classical narcotic analgesics the analgetic efficacy is not lost in derivatives bearing a hydrogen substituent at the central carbon atom.

Analgesics↗
PubMed1976

[Eye involvement in plasmocytoma (author's transl)].

A description is given of a 37-year-old man, who suffered from a IgG myelom, diagnosed by internal medicine. The initial symptoms of the disease were grey-white, crystalline deposits in the cornea and recurring inflammation of the iris in both eyes. Only when a multiple recurring exophthalmos occurred, could the diagnosis be determined through an intensive internal examination. The continuing disease was still complicated by an insufficiency of the kidneys with hypertony and beginning retinopathia angiospastica.

Adult↗