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Biomedical subjects

K Forfang

Publications and source records attributed to K Forfang.

At least 91 records · Page 5Linked to original sources
PubMed1977

Relation between left ventricular filling pressure and angiographic findings in coronary heart disease. Ventriculography used as a stress test.

In 80 male patients with coronary heart disease maximum diastolic pressure in the left ventricle (LVMDP) (usually the top of the a wave), and 'post a' end-diastolic pressure (LVEDP) before and 2 and 3 minutes after ventriculography were correlated to angiographic estimates of left ventricular function (aneurysm, ejection fraction (EF), and to lesions shown by selective coronary arteriography using a score system (coronary artery lesions index, CALI). A significant correlation between CALI and LVEDP (or LVMDP) could not be shown either before or after ventriculography. Before ventriculography, however, LVEDP and LVMDP were good predictors of left ventricular dyskinesia (aneurysm and/or EF less than 50%). A positive and significant correlation between CALI and the LVEDP (and LVMDP) increments following ventriculography (delta LVEDP, delta LVMDP) was found in patients with LVEDP (or LVMDP) below 12 mmHg before ventriculography. Using delta LVEDP the correlation coefficient was 0-51 (n = 41, P less than 0-001, 95 per cent confidence interval 0-24 to 0-88). Using delta LVMDP r = 0-47 (n = 41, 0-001 less than P less than 0-01). Delta LVEDP greater than 12 mmHg was found only in patients with triple vessel disease.

Adult↗
PubMed1977

Angina pectoris in presumably healthy middle-aged men. Validation of two questionnaire methods in making the diagnosis of angina pectoris.

In 2014 presumably healthy men aged 40-59 yr the prevalence of previously undiagnosed angina pectoris was assessed by two angina questionnaires: (1) World Health Organization Questionnaire (WHO-Q) and (2) Greater New York Health Insurance Plan Survey Questionnaire (NY-Q). The angina prevalence given by the questionnaires singly or in combination varied between 1.15 and 4.7% (lowest prevalence by the WHO-Q interview version (WHO-Qi) and highest by the WHO-Q self-administered version and the NY-Q in combination), indicating a considerable variation in prevalence with variation in criteria used. Validation of the questionnaires by means of (1) coronary angiography, and (2) follow-up in selected cases, indicated NY-Q superiority over WHO-Q in predicting the presence of coronary heart disease (CHD). WHO-Qi had a particularly low sensitivity without being more specific. However, CHD-risk factor patterns in subgroups of individuals classified as angina-positive or -negative by the respective questionnaires were similar.

Adult↗
PubMed1977

Exercise ECG and case history in the diagnosis of latent coronary heart disease among presumably healthy middle-aged men.

Previously undetected coronary heart disease (CHD) was suspected in 152 of 2014 presumably healthy males aged 40-59 yr. 63 had angina pectoris, 100 a positive exercise test and only 13 both angina and a positive exercise test. Coronary angiography was performed in 105 cases of whom 69 had a positive angiogram. A 2:1 proportion of true vs false positive diagnoses of CHD was found regardless of whether the diagnosis was suspected by the exercise test and/or the case history. Exercise test data show that CHD-suspect individuals differ only marginally from normal age counterparts irrespective of angiographic findings. However, of the 12 with a positive exercise ECG and maximal pulse greater than or equal to 2 SD below normal mean, 10 had pathologic angiograms. Of 58 with positive exercise ECGs and pathological angiograms, 43 had work performance below normal mean. By using a target pulse of 150 beats/minute 69% of the positive exercise ECGs had remained undisclosed.

Adult↗
PubMed1976

P wave terminal force and persisting ST elevations in chronic ischemic heart disease. Prediciton of left ventricular motility and diastolic pressure.

In 80 male patients with coronary heart disease P terminal force in V (V Ptf) was correlated with left ventricular end-diastolic pressure (LVEDP) and the findings by left ventricular angiography (ejection fraction (EF) and signs of aneurysm). The correlation between V Ptf and LVEDP was statistically significant (r= - 0.56, n= 80, p less than 0.001). Abnormal V Ptf ( less than -0.03 mm. second) used to detect LVEDP greater than 12 mm. Hg gave sensitivity 59 per cent (22 of 37) and specificity 88 per cent (5 of 43 false positive). The mean V Ptf in 26 patients with aneurysm and/or EF Less than 50 per cent (dyskinesia group) was -0.058 mm. second in contrast to -0.021 in patients with EF greater than 50 per cent (p less than 0.001). Abnormal V Ptf was a more sensitive parameter in separating the dyskinesia group from the others than abnormal ST elevations (sensitivity 73 vs. 54 per cent, respectively); but less specific (83 vs. 98 per cent). In this respect the specificity of V Ptf increases inversely proportionally to the V Ptf value. Both of these electrocardiographic parameters may be useful in the primary selection of patients suited for surgical treatment of coronary heart disease.

Adult↗
PubMed1976

False positive diagnostic tests and coronary angiographic findings in 105 presumably healthy males.

Among 2014 presumably healthy males aged 40-59 years coronary heart disease (CHD) was suggested in 115 in the presence of one or more of the following criteria: 1) a WHO-questionnaire on angina pectoris positive on interview, 2) typical angina during a near maximal bicycle exercise test, 3) a positive exercise ECG during and/or post exercise, 4) a Minnesota Code 1.1 on a resting ECG. Diagnostic coronary angiography was offered to all 115 CHD-suspect cases. Six refused angiography and four others were excluded. Of the remaining 105, thirty-six had less than 50% obstruction of any major coronary artery (34.3%). Eighteen (17.1%) had single, 25 (23.8%) had double and 26 (24.8%) had triple vessel disease. In 62 of the 69 with pathologic angiograms at least one obstruction greater than or equal to 75% was found. Eighty percent of the cases with proven CHD were greater than or equal to 50 years. All CHD-suggestive criteria had approximately the same diagnostic performance regardless of age, i.e., approximately one false positive/two true positives. Except for one retroperitoneal hematoma no complications to angiography occurred.

Adult↗
PubMed1974

Correlations between p wave terminal force and hemodynamic parameters in aortic stenosis. Prediction of left ventricular end-diastolic pressure.

In 38 patients with "pure" aortic stenosis, P terminal force in V(1)(V(1)Ptf) correlated well with left ventricular end-diastolic pressure (LVEDP) (n = 38, r =-0.59, p smaller than 0.001), Poorer, but nevertheless significant correlations were observed with aortic systolic pressure gradient (r = -0;32, p smaller than 0,05) and cardiac volume measured by X-ray (r = -0.34, p smaller than 0.05). No significant correlation was found between V(1)Ptf and peak systolic left ventricular pressure. If V(1)Pft more negative than -0.03 mm sec is used to detect elevated LVEDP (above 12 mm Hg), the sensitivity is 81 percent, and the specificity 86 percent. Increased left atrial volume is probably the most important mechanism of this relationship. V(1)Ptf is a useful tool for the assessment of the functional and hemodynamic state of the left ventircle in aortic stenosis.

Adolescent↗