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Biomedical subjects

K Frasch

Publications and source records attributed to K Frasch.

5 recordsLinked to original sources
PubMed2006

Health behavior in psychiatric in-patients compared with a German general population sample.

OBJECTIVE: To compare the health relevant behavior of psychiatric patients and the general population. METHOD: Health behavior of 363 psychiatric in-patients with ICD-10 diagnoses of schizophrenia, bipolar disorders, major depressive disorders and neurotic, and somatoform disorders was compared with health behavior of a representative sample of 7200 persons from German general population. RESULTS: Increased prevalence rates for smoking and illicit drug use were found for all diagnostic groups. Risk alcohol consumption was increased in patients with schizophrenia and depression. Smokers with schizophrenia had an excess cigarette consumption compared with general population. The number of unhealthy food habits was increased in all diagnostic groups, and the body mass index was found to be increased for patients with schizophrenia. Patients with depression were more physically active than general population. CONCLUSION: Poor health behavior is widespread in patients with all major psychiatric diagnoses. Interventions to reduce risk behavior and strengthen health preventive lifestyles are necessary.

Demography↗
PubMed2001

[Olanzapine and pregnancy. 2 case reports].

We report on two schizophrenic females who both had unexpected first pregnancies in their mid-thirties while being treated with olanzapine. Both patients had histories of psychosis of several years with some relapses and were treated previously with traditional antipsychotics. Since they wished to have children, no contraception had been performed past the age of 30. Both pregnancies occurred within a few months after the drug treatment was switched from traditional agents to olanzapine. Olanzapine was continued throughout the pregnancies, which were without complication. It is well known that treatment with traditional neuroleptics may lead to elevated prolactin levels and thus to relative infertility. Like clozapine, olanzapine has minimal effects on prolactin levels. These cases indicate that after switching from traditional neuroleptics to atypical agents, fertility may normalize and unplanned or even unwanted pregnancies may occur. Since olanzapine is widely prescribed, it is essential to inform women about the increased probability of pregnancy and the need of appropriate contraception.

Adult↗
PubMed2000

[Do cognitive deficits in depressive disorders remit?].

OBJECTIVE: The importance of cognitive deficits concerning schizophrenics is well-known. Much less material of that kind has been collected from patients with affective disorders, which was the aim of this clinical study. METHODS: Inclusion criterions were in- and outpatients with affective disorders (ICD-10: F31-F33) aged < 61. The clinical status was determined by use of the HAMD-21, the subjects were examined by means of standardised computerised cognitive performance tests (CGT-[M], DAUF). The results were correlated with the HAMD and the psychiatric pharmacotherapy. RESULTS: In each of the three subtests the heavily depressive group (HAMD > 24, n = 14) came off significantly (Mann-Whitney-U-Test, p < 0.05) worse than the remitted group (HAMD < or = 8, n = 18) while 8 of the 18 remitted patients showed pathological results in the CGT-(M). Only patients who took tranquilizers performed significantly worse than patients without such medication (p < 0.05). CONCLUSION: In some cases of affective disorders, a "cognitive residual syndrome" persists which is rather part of the disease than pharmacotherapy-associated.

Adult↗
PubMed1999

[Economic aspects of psychotherapy management in psychosomatics and psychiatry. A systematic survey of the literature].

Economic evaluations have become more and more important in the somatotherapeutic field. This survey's objective was to examine if the current economic evaluation techniques can be applied to psychotherapy. 8 data banks, 17 key words from the psychotherapeutic field and 14 economic key words were used, the identified original studies were classified in accordance with Drummond, the methodical quality of each study was assessed at a score between 0 and 10 points. 21 studies were found: 16 cost-benefit analyses, 4 cost-effectiveness analyses and one cost-utility analysis. The quality of the representation of the clinical results (mean value 8.6) was better than that of the economic results (mean value 6.1). It was perfectly possible to evaluate psychotherapeutic interventions with regard to economic aspects by means of the current techniques but in most cases there was a considerable lack of quality in both representation and calculation. Furthermore the evaluation type of cost-utility analysis, which is the only one that takes quality of life aspects into consideration and therewith seems to be the most appropriate approach regarding the psychotherapeutic field, has been greatly ignored.

Cost-Benefit Analysis↗