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K Fujiwara

Publications and source records attributed to K Fujiwara.

At least 685 records · Page 38Linked to original sources
PubMed1987

Intranephron distribution of epidermal growth factor immunoreactivity in the mouse.

Using a specific and sensitive epidermal growth factor (EGF) radioimmunoassay, the distribution of EGF in mouse kidneys was studied. In five portions (outer cortex, inner cortex, outer medulla I, II, and papilla) of kidney slices, the outer medulla revealed the highest immunoreactive EGF (iEGF) per wet weight of tissue. In microdissected nephron segments, the predominant iEGF per millimeter length was observed in the medullary and cortical thick ascending limbs of Henle's loop compared with other segments. It became more apparent when expressed per milligram protein. Fluorescence microscopy showed prominent staining for EGF in the thick ascending limbs of Henle's loop. The significance of the nephron heterogeneity in EGF contents is discussed.

Animals↗
PubMed1987

Myelopathy hand. New clinical signs of cervical cord damage.

A characteristic dysfunction of the hand has been observed in various cervical spinal disorders when there is involvement of the spinal cord. There is loss of power of adduction and extension of the ulnar two or three fingers and an inability to grip and release rapidly with these fingers. These changes have been termed "myelopathy hand" and appear to be due to pyramidal tract involvement. The characteristic nature of the signs permit the distinction between myelopathy and changes due to nerve root or peripheral nerve disorder. The clinical significance of these signs has been assessed against other tests and their value in management is discussed.

Fingers↗
PubMed1987

Therapeutic effect of hyperthermia combined with chemotherapy on vulvar and vaginal carcinoma.

A clinical trial was performed to investigate the efficacy of hyperthermia in combination with chemotherapy for gynecological malignancies. Sixty-nine patients with vaginal or vulvar malignancies (9 primary vulvar, 3 recurrent vulvar, 11 primary vaginal, 4 primary cervical, 40 recurrent cervical, and 2 recurrent ovarian carcinomas) were treated by thermochemotherapy (42 cases) or chemotherapy alone (27 cases). After treatment, 7 patients underwent surgery and 46 patients irradiation. The chemotherapeutic schedule was mainly a combination therapy with bleomycin and mitomycin C (B-M). Microwaves of 2.45 GHz were applied to induce local hyperthermia. The side effects of chemotherapy were not increased by hyperthermia. The rate of partial response plus complete response increased to 84% (16/19) in primary cancers and 45% in recurrent cancers by hyperthermia, compared to the respective values of 40% (2/5) and 17% (3/17) for chemotherapy alone. However, a satisfactory prognosis cannot be expected with thermochemotherapy, unless additional treatments are performed. Subsequent surgery or radiation treatment improved the progression-free interval.

Adult↗
PubMed1987

Loss of echoes from the gallbladder wall in diagnosis of fatty infiltration of the liver.

Ultrasonograms taken within 24 h before liver biopsy were evaluated retrospectively for fatty infiltration of the liver in 155 non-ascitic patients with liver diseases. Relatively high amplitude echoes of the liver as compared with the kidney were observed in all of 33 patients whose fatty infiltration of the liver occupied more than 10% of each lobule or pseudolobule irrespective of etiology. Among such patients, loss of echoes from the gallbladder wall was additionally found in 18 of 19 cases uncomplicated by hepatic fibrosis, but only in 3 of 14 cases with this complication. We conclude that fatty infiltration without fibrosis in the liver may be differentiated from that with fibrosis by ultrasonic examination.

Adult↗
PubMed1987

Thoracic myelopathy secondary to ossification of the spinal ligament.

The authors describe their experience with 26 cases of thoracic myelopathy secondary to hypertrophic ossification of the spinal ligament (posterior longitudinal ligament and/or ligamentum flavum). The clinical manifestations of this condition and results of its surgical treatment are described. The commonest symptoms were numbness or tingling in the legs and feet and gait disturbance. Most of the patients with involvement of the upper thoracic spine showed typical features of thoracic myelopathy: that is, sensory and motor deficits in both the trunk and lower extremities, sphincter disturbance, and exaggerated tendon reflexes. Several patients with involvement of the thoracolumbar junction presented with atypical symptoms of thoracic myelopathy and were sometimes misdiagnosed and treated inappropriately. Surgical treatment, particularly laminectomy, was not always successful. Inconsistencies in the surgical outcome were caused by either operative complications or reversal of the initial improvement during the follow-up period. The results of anterior surgery for the condition were more favorable; however, use of this procedure was rarely indicated.

Adult↗
PubMed1987

Postinflammatory remyelination in the spinal cord of mice infected with mouse hepatitis virus, JHM strain.

The spinal cords in mice surviving acute infection for 30 days following lumbar inoculation with mouse hepatitis virus, JHM strain, were examined for virus growth and pathologic changes by light and electron microscopy. Virus titer reached a maximum level on day 6 postinoculation (p.i.) and became negative on day 10 p.i. On days 5 to 10 p.i. there were severe disruption of myelin sheath and marked phagocytosis of myelin by macrophages. Viral particles were seen in degenerating glial cells. On days 15 to 20 p.i. proliferation of oligodendrocytes was noticed in association with thinly myelinated axons with decreased number of macrophages. On days 25 to 30 p.i. affected axons were mostly remyelinated by oligodendrocytes and the interaxonal space was packed with the processes of fibrous astrocytes containing myelin debris and lipid droplets. In the subpial areas of more widespread lesions some axons were remyelinated by Schwann cells.

Animals↗
PubMed1987

[Radiation therapy of metastatic sites in hepatoma].

Ten patients with hepatoma who had received radiotherapy for their metastatic sites have been reviewed. In 13 lesions of bone metastasis in 7 patients complete pain relief from 5 lesions (38%) was achieved, while partial relief (54%) was obtained in other lesions. Of 3 patients with a brain metastasis, one attained complete symptomatic improvement with a 65% tumor reduction, and one of the remaining two gained a symptomatic palliation. In a patient with two pulmonary metastases, intraarterial chemotherapy showed a more remarkable effect when treatment was combined with radiotherapy than intraarterial chemotherapy alone. It may be concluded that radiation therapy is effected modality for palliating metastatic lesions of hepatoma.

Aged↗